Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Rapid Communications

Rapid Communications 12: Reproductive and Developmental Endocrinology

ea0081rc12.1 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

RS 2247911 polymorphism of GPRC6A gene and serum undercarboxylated-osteocalcin are associated with testis function

Jawich Kenda , Santa Rocca Maria , Al Fahoum Sahar , Alhalabi Marwan , Di Nisio Andrea , Foresta Carlo , Ferlin Alberto , De Toni Luca

Purpose: Undercarboxylated-OCN (ucOCN), acting on the receptor GPRC6A, was shown to stimulate of testosterone (T) production in Leydig cells in rodents, in parallel with the hypothalamus/pituitary/gonadal axis mediated by luteinizing hormone (LH). Hence, reduced serum ucOCN and/or inactivating gene variants of GPRC6A, are supposed to affect testis function in humans. The aim of this study is to evaluate the association among serum ucOCN, rs2247911 GPRC6A gene polymorphism and ...

ea0081rc12.2 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Proteomic changes in response to electrical stimulations in skeletal muscle of women with PCOS

Eriksson Gustaw , Nilsson Emma , Boi Roberto , Nystrom Jenny , Stener-Victorin Elisabet , Benrick Anna

Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder affecting women of reproductive age. The main features of PCOS are hyperandrogenism and reproductive and metabolic dysfunctions. We have previously shown that muscle contractions induced by either electrical stimulations or exercise act through partially similar signaling pathways in the muscle to induce glucose uptake in the acute response. Long-term electrical stimulations decrease circulating testostero...

ea0081rc12.3 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Binding affinity affecting SHBG SNPs do not majorly affect calculated estimates of free testosterone

Walravens Joeri , Banica Thiberiu , Van Den Eynde Tibbert , Snaterse Gido , Reyns Tim , Narinx Nick , Antonio Leen , Fiers Tom , Kaufman Jean-Marc , Lapauw Bruno

Introduction: According to the free hormone transport hypothesis, only free testosterone (FT) is considered biologically active. Due to low circulating levels and technical challenges of direct FT measurements, calculators have been developed to estimate FT from serum total T, sex hormone-binding globulin (SHBG) and albumin levels. However, genetic polymorphisms altering SHBG’s binding affinity or capacity might result in calculation imprecisions with consequent incorrect...

ea0081rc12.4 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Unraveling the link between metabolism and reproduction in obese men

Papadakis Georgios , Lucie Favre , Zouaghi Yassine , Vionnet Nathalie , Niederlander Nicolas , Adamo Michela , Acierno James , Santoni Federico , Berdous Dassine , Spoerl Alexia , Paccou Emmanuelle , Aleman Yasser , Salamin Olivier , Hagmann Patrick , Messina Andrea , Pitteloud Nelly

Introduction: Obesity is a worldwide pandemic, and in men can often be associated with hypogonadotropic hypogonadism (HH), a finding consistent with a clear link between sex steroids and reproduction. In this study, we aimed to characterize the phenotypic spectrum of male obesity, focusing on the metabolic and reproductive effect of weight loss after bariatric surgery, as well as to explore the role of central inflammation.Methods: We conducted an observ...

ea0081rc12.5 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Association of Early Adulthood Hyperandrogenemia With Hypertension and Cardiovascular Events in Women

Tuorila Katri , Ollila Meri-Maija , Jarvelin Marjo-Riitta , Tapanainen Juha , Franks Stephen , Piltonen Terhi , Kaikkonen Kari , Morin-Papunen Laure

Background: Cardiovascular diseases (CVD) present sex specific characteristics, suggesting sex-hormones playing a role in the pathophysiology of CVDs. Hyperandrogenemia (HA) is a common condition in fertile age women but whether HA is a risk factor for CVD is still controversial.Aims: To clarify the association of HA with the development of hypertension and CVDs in women.Study population and methods: A general population-based birt...

ea0081rc12.6 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Is Turner syndrome at risk for thyroid carcinoma?

Belardinelli Elisabetta , Dionese Paola , Cecchetti Carolina , Vicennati Valentina , Repaci Andrea , Pagotto Uberto , Gambineri Alessandra

Background: Many questions concerning Turner Syndrome (TS) remain unresolved, such as the long-term complications and, therefore, the optimal care setting for adults. Most controversials regard tumors. Very few data are available on thyroid carcinoma and no specific screening protocol of monitoring is advised in the current official guidelines. This long-term cohort study was primarily aimed at estimating the incidence and time to comorbid conditions along the life course, inc...

ea0081rc12.7 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Pubertal induction in girls with hypogonadism: insight into estrogen replacement therapy outcomes and optimization of progesterone introduction

Rodari Giulia , Federici Silvia , Cattoni Alessandro , Todisco Tommaso , Ubertini Graziamaria , Giacchetti Federico , Profka Eriselda , Dall'Antonia Alberta , Cangiano Biagio , Arosio Maura , Bonomi Marco , Cappa Marco , Giavoli Claudia

Background: Pubertal induction in girls with hypogonadism through estrogen replacement therapy (ERT) aims at mimicking physiological puberty. To date, the best induction regimen is still to be established.Aims: By setting up a multicentre clinical registry, we analysed longitudinal data on pubertal induction in girls with hypogonadotropic hypogonadism or premature ovarian insufficiency (congenital, acquired, isolated or associated with multiple pituitary...

ea0081rc12.8 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Ethinyl estradiol in a combined contraceptive exerts greater effect on serum proteome than estradiol valerate – a randomized trial

Kangasniemi Marika , Arffman Riikka , Joenvaara Sakari , Haverinen Annina , Luiro Kaisu , Tohmola Tiialotta , Renkonen Risto , Heikinheimo Oskari , Tapanainen Juha , Piltonen Terhi

Background: Combined oral contraceptives (COC) are known to have multiple beneficial effects besides contraception, but also cause some unwanted health outcomes. They interfere, for example, with metabolism, inflammation, hepatic protein synthesis and blood coagulation. COCs containing natural estrogens have recently been developed, yet little is known about their non-contraceptive effects compared to conventional COCs with ethinyl estradiol (EE). The aim of this study was to ...