Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Rapid Communications

Rapid Communications 14: Late Breaking

ea0081rc14.1 | Rapid Communications 14: Late Breaking | ECE2022

Long-term thyroid complications in haematological cancer survivors following systemic chemotherapy, neck radiotherapy and/or haematopoietic stem cell transplantation

Carlomagno Francesco , Nardi Christopher , Tomaselli Alessandra , Pandozzi Carla , Mazzotta Paola , Gianfrilli Daniele

Introduction: With the increasing survival rates from cancer the focus has been shifting towards the adverse sequelae, occurring both acutely, or developing as late effects, deriving from its multimodality treatment.Aim: We investigated the occurrence of thyroid complications in patients with haematological malignancies treated with chemotherapy, radiotherapy involving the neck and/or haematopoietic stem cell transplantation (HSCT), referred to our endoc...

ea0081rc14.2 | Rapid Communications 14: Late Breaking | ECE2022

Prevention of glucocorticoid-induced adipose dysfunction and hepatic lipid deposition through cold acclimation in aged mice

Gado Manuel , Ghane Zahra , Heinrich Annett , Wiedersich Denise , Bornstein Stefan R , Rauner Martina , Hofbauer Lorenz C , Henneicke Holger

Glucocorticoids (GC) are one of the most potent anti-inflammatory pharmacological agents. However, owing to their pleiotropic nature, their clinical effectiveness is frequently limited by their deleterious off-target effects. Frequently, metabolic abnormalities arise from GC excess involving the development of dyslipidaemia, insulin resistance and muscle atrophy as well as excessive fat accumulation in both white adipose tissue (WAT) and the liver. In addition, suppressed ther...

ea0081rc14.3 | Rapid Communications 14: Late Breaking | ECE2022

Can early postoperative hypocalcemia be predicted preoperatively in patients operated with minimally invasive technique for primary hyperparathyroidism ?

Dellal Kahramanca Fatma Dilek , Copuroğlu Esra , Turan Erdogan Beril , Baser Husniye , Ozdemir Didem , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Aim: Postoperative hypocalcemia is seen in 26-42% patients after parathyroidectomy.There are quite a lot of studies investigating preoperative factors that might be used to predict postoperative hypocalcemia in thyroidectomized patients, however there are less studies in parathyroidectomized patients.In this study, our aim was to determine whether any preoperative clinical, laboratory or ultrasonographical feature anticipate hypocalcemia in parathyroidectomized patients due to...

ea0081rc14.4 | Rapid Communications 14: Late Breaking | ECE2022

Sequential primary adrenocortical culture system for genetic transformation and adrenocortical tumorigenesis using CRISPR/Cas9-mediated genome editing

Teresa Fuss Carmina , Hartmann Oliver , Reissland Michaela , Pahor Nikolett , Landwehr Laura-Sophie , Fassnacht Martin , Diefenbacherc Markus E

Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 per million per year. Prognosis of ACC is generally poor but variable and therapeutic approaches are scarce. While surgical resection presents the best option for definitive cure, mitotane remains the only approved drug for adjuvant therapy in ACC to date. Advancements regarding novel treatment strategies as well as fostered understanding of potential drivers of adrenocortical carcinogenesis ...

ea0081rc14.5 | Rapid Communications 14: Late Breaking | ECE2022

Calcitonin washout in the diagnosis of medullary thyroid cancer

Evranos Ogmen Berna , Ince Nurcan , Akdogan Leyla , Aksoy Altınboga Aysegul , Aydin Cevdet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Background: Medullary thyroid cancers (MTC) originate from parafollicular C cells and constitute 3-5% of all thyroid cancers. Calcitonin (CT) measurement is useful in the diagnosis of MTC. The sensitivity and specificity of CT are low in the measurement alone, and the sensitivity and specificity increase when used with pentagastrin and calcium stimulation tests. However, the difficulty of accessing pentagastrin, the uncertainty of the cut-off value in calcium stimulation tests...

ea0081rc14.6 | Rapid Communications 14: Late Breaking | ECE2022

Does the knowledge about type 2 diabetes mellitus is capable of interfering in adherence to self-care in patients?

Cardoso da Silva Thielsen , Vilas Boas Laura , Alexandre Xavier Camila , Bernart Sernajotto Joao Guilherme , Regina Rompkovski Mariana , Paulino Schuitek Rafael , Chechetto Segalla Victoria , Ribeiro Gama Mirnaluci Paulino

Introduction: Self-care plays a fundamental role in the treatment and prevention of complications of diabetes mellitus (DM). The patient knowledge about DM and its potential complications are among the factors that are associated with treatment adherence. The process of understanding the disease provides the patient better communication with professionals, better metabolic and psychosocial results which may influence on their emotional well-being and quality of life.<p cla...

ea0081rc14.7 | Rapid Communications 14: Late Breaking | ECE2022

Prognostic value of contralateral suppression on eGFR after surgery in primary aldosteronism

Krogh Jesper , Voss Nathalie , Larsen Feltoft Claus , Morup Sara , Clausen Caroline , Andreassen Mikkel

Adrenalectomy for primary aldosteronism has been associated with post-surgical kidney failure. It has been proposed that elimination of excess aldosterone demask an underlying failure of the kidney function. Contralateral suppression (CLS) is considered an indication of aldosterone excess and disease severity and the purpose of this study was to assess the hypothesis that CLS would predict change in kidney function after adrenalectomy in patients with primary aldosteronism. We...

ea0081rc14.8 | Rapid Communications 14: Late Breaking | ECE2022

Insulin resistance prevents SHBG increase after VLCKD in non-diabetic obese male subjects

Annamaria Genchi Valentina , Cignarelli Angelo , Di Leo Simona , Giordano Fiorella , Conte Eleonora , Perrini Sebastio , Natalicchio Annalisa , Laviola Luigi , Giorgino Francesco

Hepatocytes are both insulin sensitive and the primary site for synthesis of SHBG. Thus, it is possible that a condition of hepatic insulin resistance may impair hepatic synthesis of SHBG. In this study, we assessed SHBG circulating levels after 30 days of a very low-calorie ketogenic diet (VLCKD) based on high-biological value protein preparations diet (ISOMED) and natural food in a cohort of insulin-resistant obese male subjects. Moreover, we investigated the effects of expo...