Endocrine Abstracts

Introduction: With the increasing survival rates from cancer the focus has been shifting towards the adverse sequelae, occurring both acutely, or developing as late effects, deriving from its multimodality treatment.Aim: We investigated the occurrence of thyroid complications in patients with haematological malignancies treated with chemotherapy, radiotherapy involving the neck and/or haematopoietic stem cell transplantation (HSCT), referred to our endoc...

Glucocorticoids (GC) are one of the most potent anti-inflammatory pharmacological agents. However, owing to their pleiotropic nature, their clinical effectiveness is frequently limited by their deleterious off-target effects. Frequently, metabolic abnormalities arise from GC excess involving the development of dyslipidaemia, insulin resistance and muscle atrophy as well as excessive fat accumulation in both white adipose tissue (WAT) and the liver. In addition, suppressed ther...

Aim: Postoperative hypocalcemia is seen in 26-42% patients after parathyroidectomy.There are quite a lot of studies investigating preoperative factors that might be used to predict postoperative hypocalcemia in thyroidectomized patients, however there are less studies in parathyroidectomized patients.In this study, our aim was to determine whether any preoperative clinical, laboratory or ultrasonographical feature anticipate hypocalcemia in parathyroidectomized patients due to...

Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 per million per year. Prognosis of ACC is generally poor but variable and therapeutic approaches are scarce. While surgical resection presents the best option for definitive cure, mitotane remains the only approved drug for adjuvant therapy in ACC to date. Advancements regarding novel treatment strategies as well as fostered understanding of potential drivers of adrenocortical carcinogenesis ...

Background: Medullary thyroid cancers (MTC) originate from parafollicular C cells and constitute 3-5% of all thyroid cancers. Calcitonin (CT) measurement is useful in the diagnosis of MTC. The sensitivity and specificity of CT are low in the measurement alone, and the sensitivity and specificity increase when used with pentagastrin and calcium stimulation tests. However, the difficulty of accessing pentagastrin, the uncertainty of the cut-off value in calcium stimulation tests...

Introduction: Self-care plays a fundamental role in the treatment and prevention of complications of diabetes mellitus (DM). The patient knowledge about DM and its potential complications are among the factors that are associated with treatment adherence. The process of understanding the disease provides the patient better communication with professionals, better metabolic and psychosocial results which may influence on their emotional well-being and quality of life.<p cla...

Adrenalectomy for primary aldosteronism has been associated with post-surgical kidney failure. It has been proposed that elimination of excess aldosterone demask an underlying failure of the kidney function. Contralateral suppression (CLS) is considered an indication of aldosterone excess and disease severity and the purpose of this study was to assess the hypothesis that CLS would predict change in kidney function after adrenalectomy in patients with primary aldosteronism. We...

Hepatocytes are both insulin sensitive and the primary site for synthesis of SHBG. Thus, it is possible that a condition of hepatic insulin resistance may impair hepatic synthesis of SHBG. In this study, we assessed SHBG circulating levels after 30 days of a very low-calorie ketogenic diet (VLCKD) based on high-biological value protein preparations diet (ISOMED) and natural food in a cohort of insulin-resistant obese male subjects. Moreover, we investigated the effects of expo...