Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Rapid Communications

Rapid Communications 6: Endocrine-Related Cancer

ea0081rc6.1 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Clinical relevance of body composition measurement at L3 level in gastroenteropancreatic neuroendocrine tumors

Sebastian Valles Fernando , Sanchez de la Blanca Carrero Nuria , Rodriguez Laval Victor , Knott Torcal Carolina , Serrano-Somavilla Ana , Martinez-Hernandez Rebeca , Martin-Perez Elena , Munozde Nova Jose Luis , Marazuela Monica , Sampedro-Nunez Miguel

Introduction: Nutritional status in patients with neuroendocrine tumors (NETs), especially with gastroenteropancreatic origin, may be affected and have an impact on prognosis and survival. Different techniques are currently available to assess nutritional status, but not all of them are accessible in routine clinical practice. In this context, Body composition of NET patients was calculated by computed tomography (CT) at L3 level to evaluate its importance on clinical prognosi...

ea0081rc6.2 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Reciprocal interactions between fibroblast and pancreatic neuroendocrine tumor cells: putative impact of the tumor microenvironment

Cuny Thomas , Mondielli Gregoire , van Koetsveld Peter , de Herder Wouter , Barlier Anne , Hofland Leo

Introduction: Pancreatic neuroendocrine neoplasms (PNEN) present with a fibrotic stroma which constitutes the tumor microenvironment (TME). The role played by stromal fibroblasts over the growth of PNEN and their sensitivity to the mTOR inhibitor, RAD001, are as yet unestablished.Methods: We investigated reciprocal interactions between 1) human PNEN cell lines (BON-1/QGP-1) or primary cultures of human ileal neuroendocrine neoplasm (iNEN) or PNEN, and 2)...

ea0081rc6.3 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

New epigenetic and functional features in pheochromocytoma

Manso Jacopo , Bertazza Loris , Barollo Susi , Censi Simona , Carducci Sofia , Mian Caterina

Background: Pheochromocytoma (Pheo) is a tumor deriving from chromaffin cells. It can be studied using 18F-dihydroxyphenylalanine (DOPA) - positron emission tomography (PET) due to its overexpression of L-type amino acid transporters (LAT1 and LAT2). The oncogenic pathways involved are still poorly understood. This study examined the relationship between 18F-DOPA-PET uptake and LAT1 expression, and explored the role of miR-375 and putative target genes.</...

ea0081rc6.4 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Glucose-coated superparamagnetic iron oxide nanoparticles prepared by metal vapor synthesis can target GLUT1 overexpressing tumors: in vitro tests and in vivo preliminary assessment

Barbaro Daniele , Dibari Lorenzo , Gandin Valentina , Marzano Cristina , Evangelisti Claudio

Background: It is well known that one of the basic characteristics of tumor cells is that they are greedy for glucose. Delivering Glucose Coated Superparamagnetic iron oxide nanoparticles (Glc-SPIONs) to tumor cells by i.v. administration could represent “the magic bullet” for detecting and treating cancer,Materials, methods and results: Glc-SPIONs were prepared by a new approach called Metal Vapor Synthesis (MVS) and their structural features ...

ea0081rc6.5 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Granin family peptides and INSM-1 (Insulinoma-associated protein 1) in the biochemical diagnosis of pheochromocytoma

Glinicki Piotr , Ostrowska Magdalena , Stelmachowska-Banas Maria , Papierska Lucyna , Szatko Alicja , Kowalski Konrad , Zgliczyński Wojciech

Introduction: Pheochromocytoma is a rare, usually benign tumor composed of neuroendocrine (chromaffin) cells of the adrenal medulla. It is the cause of secondary arterial hypertension. The biochemical diagnosis of a pheochromocytoma is based on the determination of concentration/excretion of catecholamine metabolites in blood or urine. The most sensitive biomarkers in the biochemical diagnosis of pheochromocytoma are plasma free methanephrines (metanephrine, normetanephrine an...

ea0081rc6.6 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

The clinical and molecular evaluation of the GIP/GIPR axis in Medullary Thyroid Cancer (MTC)

Occhi Gianluca , Bertazza Loris , Barollo Susi , Galletta Eva , Mondin Alberto , Zovato Stefania , Iacobone Maurizio , Zilio Eleonora , Avallone Serena , Lefkimmiatis Konstantions , Di Benedetto Giulietta , Mian Caterina , Scaroni Carla , Regazzo Daniela

The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a 7-transmembrane class B G-protein coupled receptor that mediates the incretin response after nutrient stimulation. Although mostly involved in metabolic disorders, in the last years an improper activation of the GIP/GIPR axis has been increasingly recognized in endocrine tumors, with a potential diagnostic and prognostic value. In Medullary Thyroid Cancer (MTC), a neuroendocrine tumor of the parafollicular C...

ea0081rc6.7 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Oncological patients with endocrine complications after immunotherapy with checkpoint inhibitors present longer progression free and overall survival

Paschou Stavroula A , Liontos Michael , Eleftherakis-Papaiakovou Evangelos , Stefanaki Katerina , Markellos Christos , Koutsoukos Konstantinos , Zagouri Flora , Psaltopoulou Theodora , Dimopoulos Meletios-Athanasios

Aim: To investigate the association of endocrine complications after ICIs immunotherapy with progression free survival (PFS) and overall survival (OS) in a large single-center oncological cohort.Patients and methods: In total, 351 patients were included in the analysis, 248 men (70.7%) and 103 women (29.3%). The median age was 66 years. Patients had a variety of cancer types, namely bladder cancer (131, 37.3%), renal cancer (89, 25.4%), lung cancer (74, ...

ea0081rc6.8 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Unveiling the role and contribution of CELF4 to the malignant features of PanNETs

Vioque Victor Garcia , Alors-Perez Emilia , Arevalo Sergio Pedraza , Agraz-Doblas Antonio , Blazquez-Encinas Ricardo , Blazquez-Encinas Ricardo , Moreno Montilla Maria Trinidad , Herrera-Martinez Aura D , Yubero Serrano Elena Maria , Ortega Salas Rosa , Serrano Blanch Raquel , Galvez Moreno Maria Angeles , Gahete , Manuel D , Costa Alejandro Ibanez , Luque Raul M , Castano Justo P

Pancreatic neuroendocrine tumors (PanNETs) are heterogeneous neoplasms with a relatively low but increasing incidence, mainly due to the difficulty in diagnosing this disease in its early stages. This notably complicates the treatment of this pathology and leads to a poor prognosis. One of the main reasons for this problem is the lack of adequate diagnostic biomarkers as well as effective therapeutic targets. In this sense, there is still a limited knowledge about alternative ...