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Endocrine Abstracts (2022) 81 EP3 | DOI: 10.1530/endoabs.81.EP3

ECE2022 Eposter Presentations Adrenal and Cardiovascular Endocrinology (131 abstracts)

Impact of adrenocortical carcinoma and associated adrenal insufficiency on patient wellbeing – a systematic review

Phillip Yeoh 1 , Wladyslawa Czuber-Dochan 2 , Simon Aylwin 3 & Jackie Sturt 1


1KING’S COLLEGE LONDON, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, London, United Kingdom; 2King’s College London Waterloo Campus, United Kingdom; 3KING’S COLLEGE HOSPITAL, Endocrinology & Diabetes Dept, United Kingdom.


Context: Adrenocortical carcinoma is a rare cancer with an annual incidence of 0.7-2 cases per million population and 5-year survival of 31.2%. Adrenal insufficiency is a common and life shortening complication of ACC and little is understood about how it impacts on patients.

Objective: To understand patients’ experience of the condition, its treatment, care process, impact of AI on ACC wellbeing, self-care needs and support.

Design: Systematic review of MEDLINE, EMBASES, CINAHL, PsycINFO and Open Grey for studies published until February 2021. All research designs were included. The findings underwent a thematic analysis and narrative synthesis. Studies quality was assessed using mixed method assessment tools.

Results: A total of 2837 citations were identified; 15 titles with cohort, cross sectional, case series and case report study designs met the inclusion criteria involving 479 participants with adrenal insufficiency secondary to adrenocortical carcinoma. Quantitative research identified impacts of disease and treatment on survivorship, the burden of living with AI/ACC, toxicity of therapies, supporting self-care and AI management. These impact factors included adjuvant therapies involved and their toxicities, caregivers/family supports, healthcare and structure support in place, specialist skill and knowledge provided by healthcare professional on ACC management. No qualitative patient experiences evidence was identified.

Conclusion: ACC appears to have high impact on patients’ wellbeing including the challenges with self-care and managing AI. Evidence is needed to understand patient experience from a qualitative perspective.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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