ECE2022 Eposter Presentations Endocrine-Related Cancer (61 abstracts)
Association of tissue miRNA (MiR-146b, -21, -221, -222, -181b) expression and the overall survival of papillary thyroid carcinoma patients
Aistė Kondrotienė 1 , Albertas Dauksa 2 , Diana Pamedytytė 3 , Mintautė Kazokaitė 1 , Aurelija Žvirblienė 3 , Dalia Daukšienė 1 , Vaida Simanavičienė 3 , Raimonda Klimaitė 1 , Rasa Verkauskienė 1 & Birute Zilaitiene 1
1Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; 2Institute of Digestive Research, Medical Academy, Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania; 3Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania
Introduction: Improper management of papillary thyroid carcinoma (PTC) patients results in potentially higher fatal outcomes due to a lack of relevant prognostic markers, inadequate periodic individualized risk assessments and/or insufficient initial treatment. MiR-146b, -21, -221, -222, -181b are potential biomarkers for risk stratification in PTC.
Aim: The aim of our study was to analyze expression levels of five miRNA molecules (miR-21; miR -221; miR -222; miR -146b; miR -181b) in PTC formaline-fixed paraffin embedded (FFPE) tissue samples and evaluate their relation with the overall survival of PTC patients.
Methods: We analyzed expression of miR-221, miR-222, miR-146b, miR-21, miR-181b in FFPE PTC tissue samples of 312 patients and evaluated their relationship with the overall survival of these patients. To evaluate the association of survival rate after thyroidectomy with miR expression pattern, PTC patients were divided into two groups with high and low PTC tissue miRs expression. Patients with miR expression levels below the median values (miR-146b=2.59; miR-21=1.16; miR-221=0.79; miR-222=2.04; miR-181b=0.00048) were assigned as having low expression levels, and patients with miR above or equal to median values were assigned as having high expression levels.
Results: The median follow-up time of PTC patients was 152 (IQR 60) months. 35 deaths were recorded till the end of study. Kaplan–Meier curves estimating the overall survival of PTC patients after thyroidectomy according to high/low tissue expression levels of miR-146b, -21, -221, -222, -181b were compared using the Log rank test, however no statistically significant differences were found (P=0.479; P=0.583; P=0.383; P=0.995; P=0.516). Kaplan–Meier plots for miR-146b paired with miR-221 (median survival 141.7 months (IQR 18)), and miR-146b, miR-221, miR-21 panel (median survival 138 months (IQR 12.75)) compared by the Log-rank test demonstrated significant differences in survival curves for miR-146b, miR-21 and miR-221 panel (P=0.019).
Conclusion: Higher expression of miR-146b, miR-21 and miR-221 is associated with a decreased overall survival of PTC patients.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more