ECE2022 Eposter Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Maternal prolactin-levels in pregnancy and offspring body composition at 7 years. Odense Child Cohort
Freja Pelck Hansen 1 , Anders Grøntved 2 , Richard C Jensen 1 , Frederik D Højsager 2 , Ivan Brandslund 3 , Henriette Boye 4 , Tina Kold Jensen 4 , 4 , Marianne Andersen 1 & Dorte Glintborg 1
1Odense University Hospital, Endocrinology, Odense, Denmark; 2University of Southern Denmark, Odense, Denmark; 3Vejle Hospital, Hospital Lillebælt, Vejle, Denmark; 4Odense University Hospital, Odense, Denmark
Background: Prolactin is associated with metabolic risk inside and outside of pregnancy. Maternal prolactin levels could be associated with offspring body composition.
Aim: To investigate if maternal prolactin-levels were linked to offspring body composition at seven years of age.
Design: Prospective observational cohort study (the Odense Child Cohort).
Methods: Maternal fasting blood samples were assessed during 1st (prolactin) and 3rd trimester (prolactin and glucose). Prolactin ratio was defined as 3rd trimester/1st trimester prolactin. Offspring body composition at seven years of age was assessed by Dual-Energy X-ray Absorptiometry (DXA)-scan, BMI and waist circumference. A total of 854 mother-child-pairs were included. Gestational diabetes mellitus (GDM) was defined by WHO13-criteria (fasting glucose ≥5.1 mmol/l). Oral glucose tolerance test (OGTT) was performed around gestation week 28 in 180 women with risk factors for GDM and in 168 randomly included women. Multiple regression analyses investigated associations between maternal prolactin (continuous and quartiles) and offspring body composition stratified by offspring sex and models were adjusted for maternal age, parity and BMI.
Results: Median (quartiles) maternal age was 30 (27–33) years and pre-gestational BMI 24.5 (21.3; 26.5) kg/m2. In boys (n=301), materrnal prolactin-ratio (4th quartile) was positively associated with fat percentage (Adjusted β=0.09, P=0.02, and gynoid fat percentage (Adjusted β=0.08, P=0.04). In boys born of mothers with risk of GDM (n=135), the association between materrnal prolactin-ratio (4th quartile) and fat percentage (Adjusted β=0.13, P=0.026) and android fat percentage (Adjusted β=0.22, P=0.032) was attenuated. Maternal prolactin was not associated with body composition in girls.
Conclusions: Maternal prolactin-ratio was positively associated with fat percentage and android fat percentages in boys born of mothers at risk for GDM.
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Endocrine Abstracts
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