ECE2022 Poster Presentations Adrenal and Cardiovascular Endocrinology (87 abstracts)
Profound changes of inflammatory and cardiovascular biomarkers in patients with autonomous cortisol secretion and Cushing syndrome
Grethe Åstrøm Ueland 1 , Paal Methlie 1,2 , Kristian Løvås 1 , Åse Bjorvatn Sævik 2 , Anette Heie 1 & Eystein Sverre Husebye 1,2
1Haukeland University Hospital/Health Bergen, Norway; 2University of Bergen, Bergen, Norway
Objective: Determine inflammatory and cardiometabolic biomarkers in patients with autonomous cortisol secretion (ACS), compared with healthy controls and patients with overt Cushing syndrome (CS).
Method: Serum from prospectively included patients with ACS (n=65), overt CS (n=8), and healthy subjects (n=120) were analysed for 92 different inflammatory biomarkers using proximity extension assay.
Results: ACS and CS patients revealed significant differences in levels of 49/92 inflammatory and cardiometabolic biomarkers (46 raised/3 decreased) compared with healthy subjects. No difference in biomarker levels were found between ACS and overt CS, and the biomarker levels did not correlated with the degree of hypercortisolsim. Among the 46 raised biomarkers, 20 were cardiometabolic, and 13 were inflammatory markers. Several of the biomarkers have previously been found to be elevated in patients with overt CS. The assays showed robustness, as only three biomarkers had one outlier each in healthy subjects. Seventeen patients delivered postoperative samples, median 24 months (range 6–40) after operation and hormonal cure. There was no significant normalisation of the biomarkers postoperatively.
Conclusion: We found a systemic rise in inflammatory and cardiometabolic biomarkers among patients with ACS and CS, unrelated to the degree of hypercortisolism. Curing ACS/CS did not lead to normalisation of these biomarkers after 24 (range 6–40) months.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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