ECE2022 Poster Presentations Thyroid (136 abstracts)
Frequency of autoimmune thyroid disease in polycystic ovary syndrome: case-control study
Sawsen Essayeh 1 , Radhouan Gharbi 1 , Hiba-Allah Chatti 1 , Chedi Mhadhbi 1 , Sawsen Mnajja 1 , Sana Abdelali 2 , Hajer Kandara 1 & Ines Kammoun 1
1National Institute of Nutrition and Food Technology of Tunis, Endocrinology, Tunis, Tunisia; 2 National Institute of Nutrition and Food Technology of Tunis, Biochemistry, Tunis, Tunisia
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine pathology in women with a high prevalence varying between 5 and 20%. Autoimmune thyroid diseases (AITD) are the most prevalent organ-specific autoimmune diseases, particularly in young women. The purpose of our study was to determine the prevalence of AITD in a group of patients with PCOS compared to a control group.
Patients and Methods: 103 women were recruited into the study, aged between 18 and 46 years. They were divided into two groups matched for age and body mass index. The first group included 51 women with PCOS and the second group included 52 healthy volunteer women. Serum-free thyroxin (FT4), thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibody (anti-TPO) levels were evaluated. The diagnosis of Hashimoto’s thyroiditis was made when the participant had hypothyroidism coupled with high level of anti-TPO.
Results: The age and the body mass index were comparable between the two groups (29.6± 6.5 vs 29.2 ±6.1 years, P=0.81; 30.3±6.5 vs 29.3±8.9 Kg/m2; P=0.19). The TSH, FT4 and ant anti-TPO levels were similar in both groups (P=0.41, P=0.35, P=0.41, respectively). The frequency of Hashimoto’s thyroiditis was significantly higher in the PCOS group (21% vs 4%, P=0.01). In patients with PCOS and controls, the percentages of positive anti-TPO, subclinical hypothyroidism were similar (P=0.21, P=0.27, respectively). Graves‘disease and subclinical hyperthyroidism were not found in the two groups.
Conclusion: Hashimoto’s thyroiditis is a frequent condition in PCOS patients. Therefore, the assessment of TSH and anti-TPO should be considered in patients with PCOS during follow-up even in the absence of overt symptoms.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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