Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2022) 81 P524 | DOI: 10.1530/endoabs.81.P524

1Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; 2Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; 3Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

The adrenal gland is a crucial regulator of numerous fundamental biological processes and its hormones are essential for maintaining homeostasis in normal and stressful situations. However, the impact of hypoxia signalling on the function of the adrenal remains poorly understood. During the past years, our research group has focused on enhancing our understanding of hypoxia pathway proteins (HPPs) in the different areas of the adrenal gland. Firstly, we described a crucial role for hypoxia inducible factor-1 α (HIF-1α) during adrenal steroidogenesis (Watts et al., CMLS, 2021) and secondly, we demonstrated that HIF-2α is essential for the synthesis and release of catecholamines. Briefly, HIF-2α stabilization due to loss of prolyl hydroxylase domain protein-2 (PHD2) leads to reduced phenylethanolamine N-methyltransferase (PNMT) activity and consequent epinephrine synthesis. Simultaneously, HIF-2α mediated erythropoietin (EPO) production in renal EPO producing cells (REPCs) stimulated excessive RBC formation (erythrocytosis) leading to hypoglycaemia and increased release of epinephrine from the adrenal medulla (Watts et al., JMM, 2021). Recently, we generated a new set of mouse lines efficiently targeting the HPPs in chromaffin cells to further unravel the impact of HIF-2α -stabilisation during the development of medulla-related tumours. This will provide us with an excellent chance to enhance our current knowledge on potential targets for the therapeutic treatment of pheochromocytomas (PCCs) and paragangliomas (PGLs).

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.