ECE2022 Poster Presentations Thyroid (136 abstracts)
Postoperative thyroglobulin (Tg) as a predictor of long-term recurrence in differentiated thyroid carcinoma (DTC)
Nerea Utrilla Uriarte 1 , Miren Badiola Molinuevo 1 , Virginia Urquijo Mateos 1 , Pedro Gonzalez Fernandez 1 , José Genollá Subirats 2 & Javier Santamaría Sandi 1
1Cruces University Hospital, Endocrinology, Spain; 2Cruces University Hospital, Nuclear Medicine, Spain
Introduction: To determine the risk of recurrence in DTC, different clinical factors have been used (presence of adenopathies, extrathyroid extension, histology\..). The objective was to examine whether the value of early postoperative Tg concentration may also predict long-term recurrence of DTC.
Material and Methods: The study included 249 consecutive patients (78.3% women, mean age 50.72 ± 14.26 years) with DTC who were initially treated by total thyroidectomy ± lymphadenectomy between 2000 and 2016. Serum Tg level was measured 6-8 weeks after surgery using the Immulite 2000 Siemens method, with a sensitivity of 0.5 ng/ml. The patients have been followed-up for a minimum of 5 years (mean 7.27 ± 2.7 years) or until recurrence was detected. At the end of follow-up, their clinical situation was analyzed according to dynamic risk stratification. Patients with positive anti-Tg antibodies were excluded.
Results: The results obtained are shown in Table 1.
| Tg: | n=249 | Disease recurrence | Excellent response* |
| <0.5 ng/ml | 175 | 6 (3.4%) | 152 (86.9%) |
| 0.5-2 ng/ml | 41 | 6 (14.6%) | 25 (61%) |
| >2 ng/ml | 33 | 17 (51.5%) | 12 (36.4%) |
| *Excellent response was defined as Tg<0.2 ng/ml and no structural disease in neck sonogram.The mean time to recurrence was 35.9 months in patients with Tg<2 ng/dl and 26.4 months in those with Tg<2 ng/ml (P=ns). | |||
Conclsions: Postoperative Tg helps to predict the risk of DTC recurrence, so it should be used routinely in the postoperative evaluation of these patients. 2. In our series, Tg >2 ng/ml predicts a high risk of long-term recurrence, so therapeutic measures and surveillance should be intensified.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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