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Endocrine Abstracts (2022) 81 RC1.5 | DOI: 10.1530/endoabs.81.RC1.5

1Amsterdam UMC, Vrije Universiteit Amsterdam, Endocrinology, Amsterdam, Netherlands; 2Amsterdam UMC, University of Amsterdam, Radiology, Amsterdam, Netherlands; 3Amsterdam UMC, University of Amsterdam, Endocrinology, Amsterdam, Netherlands; 4Leiden University Medical Center (LUMC), Clinical Epidemiology, Leiden, Netherlands


Objective: Visceral adipose tissue (VAT) and liver fat content are associated with insulin resistance and cardiovascular disease and show clear sex differences. Our objective is to determine the effect of estradiol and testosterone on VAT and liver fat content in trans women (assigned male at birth, identify as female) and trans men (assigned female at birth, identify as male).

Design: Open-label partly randomized intervention study in 8 trans women and 18 trans men, receiving hormone treatment.

Methods: Trans women were treated with triptorelin for 6 weeks, followed by triptorelin and estradiol for 52 weeks. VAT, abdominal subcutaneous adipose tissue (SAT) and liver fat content were quantified by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) at baseline, 6, 8, 18 and 58 weeks. Trans men were randomized to receive triptorelin and testosterone with or without anastrozole for 12 weeks, followed by only testosterone until week 52. VAT, SAT and liver fat content were determined at baseline, 6, 12 and 52 weeks.

Results: In trans women, after 58 weeks, VAT did not change (+1% (95% CI -14 to 17), SAT increased by 33% (21 to 44), the VAT/SAT ratio decreased by 0.19 (-0.28 to -0.10) and liver fat content decreased by 37% (-65 to -10), compared to week 6 (start of estradiol). In trans men with anastrozole, SAT increased by 9% (2 to 17) after 12 weeks, while VAT, VAT/SAT ratio and liver fat content did not change. In trans men without anastrozole, after 52 weeks, VAT increased by 34% (16 to 51), SAT by 15% (8 to 21), VAT/SAT ratio by 0.06 (0.03 to 0.10) and liver fat by 1% (0 to 2).

Conclusions: Sex steroids regulate liver fat content and body fat distribution in both men and women.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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