ECE2022 Rapid Communications Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 (8 abstracts)
An observational retrospective study on the association of urine metanephrine levels with cardiometabolic risk in patients with nonfunctioning adrenal incidentaloma
Maria Chiara Di Carlo 1 , Mirko Parasiliti Caprino 1 , Chiara Lopez 1 , Martina Bollati 1 , Fabio Bioletto 1 , Chiara Sola 1 , Federico Ponzetto 1 , Iacopo Gesmundo 1 , Fabio Settanni 2 , Ezio Ghigo 1 , Giulio Mengozzi 2 , Mauro Maccario 1 & Roberta GIORDANO 1
1University of Turin, Endocrinology, Diabetes and Metabolism, Turin, Italy; 2University of Turin, Clinical Biochemistry Laboratory, Turin, Italy
Background: Several studies argued that the cardiovascular evaluation of patients with nonfunctioning adrenal incidentaloma is of particular importance, even if a direct association seems difficult to underline.
Objective: We aimed to evaluate the possibility of stratifying cardiometabolic risk through metanephrine levels in patients with incidentally discovered nonfunctioning adrenal adenoma.
Design: In this retrospective cross-sectional study, we collected data of metanephrine levels in 828 patients with nonfunctioning adrenal incidentaloma, referred to the Division of Endocrinology, Diabetes and Metabolism of the University Hospital of Turin between September 2007 and September 2021.
Results: The univariate analysis showed associations between urine metanephrines and cardiometabolic variables/parameters, particularly considering the noradrenaline metabolite. At univariate regression, normetanephrine was associated with metabolic syndrome (OR=1.13, 95% CI 1.05-1.22; P=0.002), hypertensive cardiomyopathy (OR=1.09, 95% CI 1.01-1.18; P=0.026), microalbuminuria (OR=1.14, 95% CI 1.00-1.25; P=0.024), and with eGFR<60 ml/min/1.73 m2 (OR=1.11, 95% CI 1.02-1.19; P=0.013), while metanephrine was associated with microalbuminuria (OR=1.50, 95% CI 1.11-1.85; P=0.008). At multivariate regression, considering all major cardiovascular risk factors as possible confounders, normetanephrine retained a significant association with metabolic syndrome (OR=1.10, 95% CI 1.01-1.19; P=0.037). Moreover, metanephrine retained a significant association with the presence of microalbuminuria (OR=1.66, 95% CI 1.21-2.98; P=0.003).
Conclusions: The present study demonstrated a further role for metanephrines in the cardiovascular risk stratification of patients with nonfunctioning adrenal incidentaloma. Individuals with high levels of these indirect markers of sympathetic activity should be carefully monitored and may benefit from an aggressive treatment to reduce their additional cardiometabolic burden.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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