Endocrine Abstracts

Case History: A 70-year-old man of Chinese origin presents with a two-month history of worsening visual acuity and double vision. He denied systemic symptoms apart from marginal weight loss. Other medical history includes stable asthma, treated with inhalers. He has a niece and nephew with thyroid disease. He is an ex-smoker, retired accountant, and drinks occasional alcohol. On examination, he was normotensive with a body mass index of 22 kg/m2 however was found to...

Case history: 61 year old female with a history of inherited dilated cardiomyopathy was referred with abnormal thyroid functions not improving with Levothyroxine. She has been on Levothyroxine 100 mg which she has discontinued 5 months prior to the review but her thyroid function abnormality persisted. She had no family history of thyroid abnormalities.Investigations: Negative TSH receptor antibodies.Treatment and follow up:<table boarder="1" cellpad...

Introduction: Discordant thyroid function tests are frequently identified in clinical practice and should raise suspicions about laboratory analytical interference.Case report: A 59 year old male was referred to Endocrine services for abnormal thyroid function tests following his recent Emergency department presentation with palpitations. His TFT (Roche) showed FT4 level was raised at 27.1 pmol/l (6.5 - 17.0), and his TSH normal at 2.57 uIU/ml (0.34 - 5....

A 26 year old gentleman presented to his GP in July 2018 with a one month history of thyrotoxic symptoms, including palpitations and weight loss. His initial thyroid function tests (TFTs) showed a hyperthyroid picture, including a FT4 of >100pmol/l (RR 12-22). His TSH receptor antibody was 11.1 IU/l (RR <1.75). He had no evidence of thyroid eye disease, and no goitre or thyroid nodules on exam. His Graves” disease was initially managed medically with carbimazole. ...

Case 1: A 17-year-old female was referred to the endocrinology outpatients due to abnormal thyroid function tests (TFTs) (as below) detected on routine monitoring for Thyroxine replacement therapy. Following exclusion of pregnancy, possibilities of assay interference due to heterophilic antibodies as well as thyroid hormone resistance were considered. Repeat analysis was arranged at two laboratories using different methods. Results were concordant, excluding assay interference...