Endocrine Abstracts

Introduction: Children with long-standing primary hypothyroidism usually have growth retardation, neurodevelopmental impairment, and delayed puberty. However, paradoxical precocious puberty, namely Van Wyk-Grumbach syndrome (VWGS), has been described. The postulated mechanism is high levels of TSH stimulate gonadal FSH receptors, resulting in ovarian over-stimulation and precocious puberty. Since the enlarged ovarian cyst is commonly found in VWGS, malignancy is often suspecte...

Introduction: The tyrosine kinase inhibitor (TKI) lenvatinib, used in radioiodine-refractory differentiated thyroid cancer, is usually well-tolerated. However, severe side effects can occur. We describe a life-threatening complication under lenvatinib, followed by a challenging treatment with levothyroxine (LT4).Case Report: A 62-year-old man was diagnosed with a bone-metastasized Hurthle cell thyroid carcinoma (pT3N0M1). He underwent a total thyroidecto...

Introduction: The thyroid gland and COVID-19 infection with its associated inflammatory-immune responses are known to be engaged in complex interplay. Until now, the evidence on the outcome of COVID-19 in patients with a history of thyroid cancer remains scarce, and most of the recommendations given are based on common sense.Case report: A 71-year-old man was admitted to Mikaelyan University hospital with general weakness shortness of breath, hiccup and ...

Introduction: How to differentiate lymphadenitis from parathyroid gland?Case report: The patient, a 45-year-old woman, applied to “Muratsan” Polyclinic complaining of asthenia, dry skin, easy fatigability, muscle and bone pain, palpitations. Anamnesis was gained and an examination was carried out. According to the patient’s indication in the anamnesis, total thyroidectomy was done a year before, followed by radioiodine therapy with regard ...

Introduction: Is treatment with Levothyroxine indicated for subclinical hypothyreosis concomitant with Carpal Tunnel Syndrome?Case Report: The patient, a 35-year-old woman, applied to “Muratsan” Polyclinic in Armenia with complaints of weakness, fatigue, dry skin, pain in hands, swelling, numbness, all these intensified at night. The above mentioned complaints appeared approx a year ago.The following findings have been de...

28 years old woman has presented to the Armenian-American Wellness Center complaining of muscular weakness, fatigue, palpitation, dysphagia, dry skin and hair fall. The patient was visited by the endocrinologist and referred to the following tests: ultrasound of the thyroid gland, blood test for TSH, FT4 and anti-TPO.Results: Diffusely enlarged thyroid gland with diffuse heterogeneous echotexture and the presence of hypoechoic micronodules. In the left l...

Introduction: De Quervain’s thyroiditis, also known as subacute granulomatous thyroiditis, is a self-limiting inflammatory disorder of the thyroid gland. It is presumed to be caused by a viral infection and many patients have a history of an upper respiratory infection 2-8 weeks prior to the onset of thyroiditis. It is the most common cause for neck pain or discomfort, and it usually has a predictable course of thyroid function evolution. On ultrasonography the thyroid gl...

Inroduction: Primary hyperparathyroidism most commonly presents with hypercalcemia. Rarely, parathyroid apoplexy or haemorrhage, mimicking a thyroid bleeding cyst is the first presentation of a parathyroid adenoma(1,3).Case Report: A 55-year-old woman presented to the ENT department with a sudden onset painful goiter. Ultrasound revealed a sharply defined hypoechogenic nodule in the right thyroid lobe measuring 24.1 x 17.8 x 18.2 mm. The patie...

Pseudomalabsorption of Levothyroxine Hypothyroidism due to non-compliance with levothyroxine therapy (pseudomalabsorption) is rare. The diagnosis is considered in patients with persistent refractory hypothyroidism despite treatment high doses of levothyroxine. Intestinal malabsorption, drug and dietary interference with levothyroxine absorption and nephrotic syndrome should be excluded. The diagnosis of pseudomalabsorption can be demonstrated by using levothyroxine absorption ...