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44th Annual Meeting of the European Thyroid Association (ETA) 2022

Brussels, Belgium
10 Sep 2022 - 13 Sep 2022

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Poster Presentations

Hypothyroidism Treatment

ea0084ps2-06-47 | Hypothyroidism Treatment | ETA2022

Prescription of levothyroxine and concurrent use of anti-arrhythmic and bone-anti-resorptive drugs in belgium: retrospective study in a large population sample

Boets Liesbeth , Van Den Bruel Annick , Van Haecht Chris , Debbaut Bernard , Ntahonganyira Rose-Marie , Cornelis Koen , Stokx Jocelijn , Decallonne Brigitte

Background and objective: Increased prescription of levothyroxine (LT4) has been observed in the USA and countries in Europe and has been related to increased thyroid function screening and a lower treatment threshold, increasing risk for overdiagnosis and overtreatment. We wanted to study the evolution of LT4 prescriptions in Belgium, and compare the use of anti-arrhythmic drugs (AAD) and bone-anti-resorptive drugs (BAD) between LT4-users and non-LT4-users.<p class="abste...

ea0084ps2-06-48 | Hypothyroidism Treatment | ETA2022

Pseudomalabsorption of levothyroxine: munchausen’s syndrome, compliance defects or fraud?

Campi Irene , Carrara Silvia , Federici Silvia , Trevisan Matteo , Persani Luca , Fugazzola Laura

Objectives: Factitious disorder imposed on self or Munchausen’s syndrome (MS), is a psychiatric disorder in which physical symptoms are intentionally produced without any practical benefit. Patients with MS represent a diagnostic dilemma as laboratory and clinical results can be inconsistent with the history and physical exam. The aim of this study was to evaluate the role of the levothyroxine overload test to differentiate MS from malabsorption and to treat life-threaten...

ea0084ps2-06-49 | Hypothyroidism Treatment | ETA2022

Faecal microbiota composition in patients with increased need of levothyroxine

Virili Camilla , Filardo Simone , Stramazzo Ilaria , Capriello Silvia , Giulia Santaguida Maria , Gargano Lucilla , Sessa Rosa , Centanni Marco

Objectives: Variations of gut microbiota composition have been described in patients with different thyroid disorders. The site of oral levothyroxine (T4) absorption is represented by the small intestine and it has been demonstrated that some bacterial strains possess enzymatic activity that may affect iodothyronine deconjugation, process probably involved in thyroid hormone enterohepatic recycling. The relationship between gut microflora composition and oral T4 requirement ha...

ea0084ps2-06-50 | Hypothyroidism Treatment | ETA2022

TSH levels assessment in hypothyroid patients treated with liquid or tablet l-thyroxine

Antonelli Alessandro , Martina Ferrari Silvia , Elia Giusy , Ragusa Francesca , Rosaria Paparo Sabrina , Mazzi Valeria , Botrini Chiara , Fallahi Poupak

Objective: Tablet levothyroxine (L-T4) is the common used therapy for hypothyroidism. In order to assess a good compliance to the therapy, treated patients are monitored with the execution of annual thyroid hormonal test. The stability of TSH levels in hypothyroid patients (with no malabsorption issues), treated with liquid L-T4, compared to that of the patients treated with tablet L-T4, remained a poorly understood topic. This study has the purpose to deepen this issue.<p...

ea0084ps2-06-52 | Hypothyroidism Treatment | ETA2022

The effect on serum tsh levels in patients in treatment with proton pump inhibitors after the switch from oral L-T4 tablet to a liquid L-T4 formulation

Fallahi Poupak , Martina Ferrari Silvia , Elia Giusy , Ragusa Francesca , Rosaria Paparo Sabrina , Mazzi Valeria , Antonelli Alessandro

Objective: The treatment with proton pump inhibitors (PPI; omeprazole, pantoprazole, lansoprazole) used for gastritis, gastric ulcer, etc. could lead to L-thyroxine (L-T4) malabsorption issues, that is induced by the increased gastric pH. Many factors like age, way of assumption (during breakfast or with food), other drugs interferences, drug-kinetics, adherence to therapy, could impair the L-T4 absorption.Methods: The study involved 27 hypothyroid patie...

ea0084ps2-06-53 | Hypothyroidism Treatment | ETA2022

Whole-body oxidative stress measured by biomarkers of RNA and DNA damage is higher in hypothyroid women, even after treatment, than in healthy individuals, measured by biomarkers of RNA and DNA damage

R. Riis Kamilla , B. Larsen Camilla , R. Medici Bjarke , Jensen Christian Z. , H. Winter Kristian , L. Larsen Emil , Bronden Andreas , Ellervik Christina , L. la Cour Jeppe , Hegedus Laszlo , H. Brix Thomas , E. Poulsen Henrik , Faber Jens , K. Knop Filip , Nygaard Birte , J. Bonnema Steen

Introduction: Hypothyroidism has been associated with oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent whole-body RNA and DNA oxidation. While these biomarkers have been associated with increased morbidity and mortality in various diseases, they have been only sparsely explored in patients with thyroid disorders.Method: In 45 women with newly diagn...

ea0084ps2-06-54 | Hypothyroidism Treatment | ETA2022

Treatment of hypothyroidism in europe by specialists: an international survey (THESIS): analysis of contested indications for prescribing among uk participants

R Younes Younes , Perros Petros , Hegedus Laszlo , Papini Enrico , V Nagy Endre , Attanasio (ORCID: 0000-0002-1417-287X) Roberto , Negro Roberto , C.T. Field (ORCID: 0000-0002-1883-1588) Benjamin

Objectives: We present findings from the UK arm of the THESIS collaboration, a pan-European survey of endocrinologists’ opinions and current practice in the management of hypothyroid and euthyroid disorders.Methods: UK clinical members of the Society of Endocrinology and the British Thyroid Association were invited to participate in an online survey.Results: 272 of 1295 (21%) eligible members completed the survey. More than 50...

ea0084ps2-06-55 | Hypothyroidism Treatment | ETA2022

Free T3 levels and clinical status of patients with levothyroxine-compensated primary hypothyroidism: can we do better?

Ramalho Diogo , Almeida Lucia , Ferreira Marta , Correia Sara , Alves Helena , Carmona Henrique , Rocha Gustavo , Joao Oliveira Maria

Objectives: To evaluate the relationship between free T3 (FT3) levels with symptoms suggestive of thyroid dysfunction, and quality of life (QoL) outcomes, in patients with compensated primary hypothyroidism (PH).Methods: Cross-sectional study encompassing Portuguese levothyroxine(LT4)-treated patients for PH who presented Thyroid-stimulating hormone (TSH) and free T4 (FT4) within the normal range. Pregnant women, patients with central hypothyroidism and/...

ea0084ps2-06-56 | Hypothyroidism Treatment | ETA2022

Polychlorinated biphenyl congeners PCB 118 and PCB 126 induce upregulation PD-L1 expression in human thyrocytes through aryl hydrocarbon receptor (AHR) pathways

Ruggeri Rosaria , Minuti Aurelio , Aliquo Federica , Giani Fiorenza , Campenni Alfredo , Trimarchi Francesco , D'Ascola Angela , Cannavo Salvatore

Objective: Polychlorinated biphenyls (PCBs) are persistent organic pollutants that that have been reported to cause a variety of toxic effects, including inflammation and cancer, through binding to the aryl hydrocarbon receptor (AhR). In turn, AhR promotes xenobiotic detoxification and antioxidant defense, by up-regulating specific responsive genes, the so-called “AhR gene battery”. AhR is also involved in modulation of immune response, by regulating programmed cell ...