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44th Annual Meeting of the European Thyroid Association (ETA) 2022

Brussels, Belgium
10 Sep 2022 - 13 Sep 2022

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Poster Presentations

Thyroid Cancer Diagnosis & Treatment

ea0084ps3-15-133 | Thyroid Cancer Diagnosis & Treatment | ETA2022

European thyroid association guideline on the management of pediatric thyroid nodules and thyroid carcinoma

Lebbink Chantal A. , Links Thera P , Czarniecka Agnieszka , P Dias Renuka , Elisei Rossella , Izatt Louise , Krude Heiko , Lorenz Kerstin , Luster Markus , Newbold Kate , Piccardo Arnoldo , Sobrinho Simoes Manuel , Takano Toru , Paul van Trotsenburg AS , A Verburg Frederik , M van Santen Hanneke

Objectives: At present no European recommendations for the management of pediatric thyroid nodules and differentiated thyroid carcinoma (DTC) exist. Differences in clinical, molecular, and pathological characteristics between pediatric and adult DTC emphasize the need for specific recommendations for the pediatric population.Methods and results: An expert panel was instituted by the executive committee of the European Thyroid Association (ETA) including ...

ea0084ps3-15-134 | Thyroid Cancer Diagnosis & Treatment | ETA2022

Patient-reported outcomes (PROS) from patients with RET-mutant medullary thyroid cancer (MTC) and ret fusion-positive TC treated with pralsetinib in the arrow trial

Hadoux Julien , I Hu Mimi , S. Brose Marcia , Garralda Elena , Spitzweg Christine , Reguart Noemi , Do Cao Christine , D. Forster Martin , Alonso-Gordoa Teresa , Barata Teresa , Scalori Astrid , Zalutskaya Alena , Trask Peter , Subbiah Vivek

Objectives: RET alterations are targetable oncogenic drivers in TC. Patients with TC, especially those with MTC treated with the multikinase inhibitors cabozantinib and/or vandetanib (C/V), often experience significant treatment-related side effects. Pralsetinib, a selective RET tyrosine kinase inhibitor, showed efficacy in patients with RET-altered TC from the phase 1/2 ARROW trial (NCT03037385). We present the impact of pralsetinib on PROs in patients with ...

ea0084ps3-15-135 | Thyroid Cancer Diagnosis & Treatment | ETA2022

Clinical relevance of lower titer thyroglobulin (TG) autoantibodies in patients with differentiated thyroid carcinoma

Dekker Bernadette , van der Horst-Schrivers Anouk , Brouwers A.H. , Shuford Chris , Kema Ido , Muller Kobold Anneke , Links Thera

Objectives: Thyroglobulin (Tg) is an established tumor marker for differentiated thyroid carcinoma (DTC) patients. However, Tg immunoassays can be subject to autoantibody (TgAb) interference resulting in incorrect Tg values. Tg measurement with liquid chromatography-tandem mass spectrometry (LC-MS/MS) could be promising in patients with TgAbs. In this study, we compared a Tg immunoradiometric assay (Tg-IRMA) and a Tg-LC-MS/MS analytically in the presence of TgAbs. Furthermore,...

ea0084ps3-15-136 | Thyroid Cancer Diagnosis & Treatment | ETA2022

The role of core needle biopsy in the diagnosis of primary thyroid lymphoma and anaplastic thyroid carcinoma: a systematic review and meta-analysis

Goedseels Nathan , Decallonne Brigitte , Hauben Esther , Van Lierde Charlotte , Meulemans Jeroen , Delaere Pierre , Vander Poorten Vincent

Objective: Anaplastic thyroid carcinoma (ATC) and primary thyroid lymphoma (PTL) are two highly aggressive malignancies of the thyroid, both leading to a rapidly enlarging neck mass. Fine-needle aspiration cytology (FNAC) is generally performed as the primary examination for diagnosis in thyroid pathology but shows low sensitivity in diagnosing ATC or PTL. Non-diagnostic FNACs are usually followed by core-needle biopsy (CNB) or diagnostic surgery. As sensitivities of up to 100...

ea0084ps3-15-137 | Thyroid Cancer Diagnosis & Treatment | ETA2022

Tendency of progression of antithyroglobulin antibody as a predictor of prognosis in patients with papillary thyroid carcinoma

Carvalho Dias Pinto Camila , Vera Montali da Assumpcao Ligia , Zantut Wittmann Denise Engelbrecht

Objectives: The clinical significance of antithyroglobulin antibody (TgAb) levels verified concomitantly with undetectable thyroglobulin (Tg) during the follow-up of patients with differentiated thyroid carcinoma remains under debate. The present study aimed to evaluate the presence and prognostic predictive value of TgAb during the follow-up of patients with differentiated thyroid carcinoma.Methods: A retrospective cohort study was performed by reviewin...

ea0084ps3-15-138 | Thyroid Cancer Diagnosis & Treatment | ETA2022

Routine molecular analysis of fine-needle aspiration biopsies of thyroid nodules

Sykorova Vlasta , Moravcova Jitka , Vaclavikova Eliska , Pekova Barbora , Mastnikova Karolina , Vcelak Josef , Novak Zdenek , Pacesova Petra , Grimmichova Tereza , Jiskra Jan , Bendlova Bela

Objectives: Molecular testing of fine-needle aspiration biopsy (FNAB) samples is increasingly used mainly for indeterminate categories of the Bethesda System for Reporting Thyroid Cytopathology. Our aim was to introduce a routine molecular analysis of the main genetic causes of thyroid cancer.Methods: In total, 1354 FNAB samples of thyroid nodules were analyzed. Testing procedures mainly in samples evaluated as Bethesda categories III and above were grad...

ea0084ps3-15-139 | Thyroid Cancer Diagnosis & Treatment | ETA2022

Thyroid lymphoma - lessons learned when time is of the essence

Luis Pinheiro Joao , Santos Andreia J. , Gomes Aline , Santos Natalia , Vicente Joao , Oliveira Ana

Introduction: Primary thyroid lymphoma is rare and accounts for less than 5% of all thyroid malignancies. The risk is almost 60 times higher in those with thyroiditis and is more common in females, with a ratio of 4:1. The most frequent local symptom is a rapidly enlarging thyroid gland along with the resultant obstructive symptoms. Fine needle aspiration is the initial diagnostic procedure for thyroid tissue sampling. The main differential diagnosis is anaplastic thyroid carc...

ea0084ps3-15-140 | Thyroid Cancer Diagnosis & Treatment | ETA2022

Basal calcitonin as guide for an early and safe thyroid surgery in RET gene carriers

Prete Alessandro , Gambale Carla , Bottici Valeria , Cappagli Virginia , Matrone Antonio , Materazzi Gabriele , Basolo Fulvio , Romei Cristina , Elisei Rossella

Introduction: Virtually all familial cases of Medullary Thyroid Carcinoma (MTC) have a RET germline mutation. Subjects harboring RET germline mutation without unaware of their condition are defined gene carriers (GC). Thyroid surgery timing is decided upon RET mutation and calcitonin levels (both basal, bCT, and stimulated, sCT). However, bCT and sCT thresholds for planning thyroid surgery have not been established, yet.Methods...

ea0084ps3-15-141 | Thyroid Cancer Diagnosis & Treatment | ETA2022

What do different echogenic micro-foci in papillary thyroid carcinoma nodules and metastatic lymph nodes represent in histopathology?

Bahcecioglu Begum , Gursoy Alptekin , Ilgan Seyfettin , Bilezikci Banu , Dizbay Sak Serpil , Erdogan Murat

Objective: Ultrasonographic (US) echogenic micro-foci are frequently seen in papillary thyroid carcinoma (PTC). General belief is that microcalcifications represent psammoma bodies. But the subject is debatable and other sonographic intranodular echogenic figures can be seen in PTC. We aimed to examine the nonshadowing echogenic figures and their histopathological correlations in PTC.Methods: We prospectively collected US video records of PTC cases with ...