Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2022) 84 PS1-01-07 | DOI: 10.1530/endoabs.84.PS1-01-07

ETA2022 Poster Presentations COVID & Thyroid Disease (9 abstracts)

The course and outcome of subacute thyroiditis: A retrospective analysis and predictive model

Jeroen de Filette 1 , jonas de rop 1 , kurt barbé 2 & bert bravenboer 1


1Universitair Ziekenhuis Brussel, Diabetologie & Endocrinologie, Jette, Belgium; 2Vrije Universiteit Brussel (Vub), Research Group Biostatistics and Medical Informatics, Brussel, Belgium


Background: Subacute thyroiditis (SAT) is a destructive thyroiditis which is presumably caused by a viral infections or post-viral inflammatory response. Thyroid dysfunction evolves through a set of stages (hyperthyroidism - hypothyroidism - euthyroidism) and is usually temporary, although some patients may develop permanent hypothyroidism. The risk factors for permanent hypothyroidism remain unclear.

Methods: A retrospective analysis of patients with SAT of the University Hospital of Brussels from 2001 to 2020. Firstly, a description of the patient characteristics, inflammatory and thyroid parameters is provided. Secondly, a predictive model for the need to initiate thyroid hormone therapy (THT) is developed by means of a logistic regression analysis. The optimal model configuration was selected by a forward sequential analysis maximizing the classification accuracy while the prediction performance was validated by a leave-one-out cross validation.

Results: 35 patients were included, with a female predominance (ratio 4.8/1). Thyrotoxicosis was detected in the majority of patients (91%), while hypothyroidism developed in 71% (of which 27% subclinical). Thyroid replacement therapy was initiated in approximately half of patients (18/35). The discontinuation of THT was attempted in 10/18 patients, and was successful in most of these (8/10). The logistic regression model selected the predictors Age, Season and Regimen, and demonstrated a maximum accuracy of 86%, classifying 30 of 35 patients correctly in the outcome measure for what the model fit is concerned, while during a leave-one-out cross validation the accuracy is 74% predicting 28 of 35 patients correctly.

Conclusion: THT was initiated for hypothyroidism in half of the patients, which is higher than previously reported. A scoring model, applicable in clinical practice to identify patients who may benefit from THT, was developed.

Volume 84

44th Annual Meeting of the European Thyroid Association (ETA) 2022

Brussels, Belgium
10 Sep 2022 - 13 Sep 2022

European Thyroid Association 

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