Endocrine Abstracts

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Hybrid closed-loop systems for managing type 1 diabetes are now available and rapidly being integrated into routine clinical practice. Insulin delivery is automated in a closed-loop system via an algorithm that uses CGM data to direct insulin delivery via an insulin pump, but users need to carbohydrate count and give pre-prandial insulin to achieve optimal outcomes. Understanding the principals of closed-loop insulin delivery, and how it differs from traditional insulin pump t...

Diabetic retinopathy is a serious complication of diabetes that can lead to vision loss and blindness. With the prevalence of diabetes rising in children, the number of young people at risk of developing diabetic retinopathy is expected to increase in the coming years. Current treatments for diabetic retinopathy only target the end-stages of the disease when significant retinal damage has already occurred. Thus, there remains an unmet medical need for new treatments, particula...