Endocrine Abstracts

Children and young people (CYP) at clinical onset of Type 1 diabetes (T1D) usually present with the classical symptoms of polyuria, polydipsia and weight loss with evidence of hyperglycaemia. A proportion with new onset T1D progress to metabolic decompensation and present with diabetic ketoacidosis (DKA), characterised by hyperglycemia and acidosis. DKA is a major medical emergency which untreated results in coma and death. The proportion of those with DKA at diabetes onset va...

Optimising postprandial glycaemia remains one of the most challenging aspects of diabetes management. The addition of fat and protein to a meal containing carbohydrate increases the post prandial glycaemic excursion but current meal insulin dose algorithms are generally based on the carbohydrate content of the meal and until recently have not included the influence of fat and protein on postprandial glucose excursions. Traditionally several factors are used to account for the effects o...