Searchable abstracts of presentations at key conferences in endocrinology
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49th Annual Meeting of the British Society for Paediatric Endocrinology and Diabetes

Belfast, Ireland
02 Nov 2022 - 04 Nov 2022

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49th Meeting of the British Society for Paediatric Endocrinology and Diabetes

ea0085p47 | Adrenal 2 | BSPED2022

Salivary sampling in neonates, infants, and young children: glucocorticoid stability under different conditions and the introduction of a novel collection technique

Tonge Joseph , Keevil Brian , Craig Jessica , Whitaker Martin , Ross Richard , Elder Charlotte

Background: Measurement of salivary glucocorticoids is gaining popularity as it offers a non-invasive collection technique, enabling sampling in the community or home environment, allowing tailored capture of steroid circadian rhythm and improved patient experience. Current popular salivary collection methods cannot be used in very young children due to choking and the requirement for active participation. There is little data on saliva stability during home collection.<p ...

ea0085p48 | Adrenal 2 | BSPED2022

Phenotypic variability in X-linked adrenoleukodystrophy

Suntharesan Jananie , Senniappan Senthil

Introduction: X-linked adrenoleukodystrophy (X-ALD) is due to mutation in ABCD1 with variable clinical phenotype and severity. Elevated plasma VLCFA is seen in all affected males. However, the clinical phenotype is not collated with VLCFA plasma concentration or by the type of ABCD1 variant. Clinical presentation can be widely variable ranging from childhood cerebral adrenoleukodystrophy (CALD), adolescent CALD, adrenomyloneuropathy and/or adrenal insufficiency. We present a s...

ea0085p49 | Adrenal 2 | BSPED2022

Effect of high-dose maternal steroids on neonatal adrenal function

Ahmed Aneeq , Gopalakrishna Nagapratheek , Hattangadi Ibani , De Silva Shamani , Ferguson Elspeth , Elder Charlotte

Background: Limited data support concerns that corticosteroid use in pregnancy, for maternal health reasons, can suppress the neonatal Hypothalamic-Pituitary-Adrenal (HPA) axis. We sought to determine if neonates born to mothers on high-dose steroids are at risk of adrenal suppression.Methodology: Our tertiary neonatal unit guidance advises that babies born to mothers receiving ≥7.5 mg/day prednisolone for 28 consecutive days in the 3rd trimester u...

ea0085p50 | Adrenal 2 | BSPED2022

Safety alerts for patients at high risk of acute adrenal insufficiency

Archibald Jessica , Coxson Edward , Edmonds Clare

Background: Acute adrenal insufficiency is a medical emergency and patients at risk of adrenal crisis should be treated immediately with glucocorticoid replacement. Our aim was to ensure there were safety alerts in place for health care professionals managing steroid dependent patients, to highlight their risk of adrenal insufficiency, and therefore prevent delays in life saving treatment.Methods: Review of the electronic documentation of all the steroid...

ea0085p51 | Adrenal 2 | BSPED2022

Paediatric adrenocortical carcinoma presents with virilization and glucocorticoid deficiency – a rare presentation

Dimarsha de Silva U. A .M. , Suntharesan Jananie , Somathilaka Mahendra , Liyanage Janath , A. Hemali de Silva M.

Background: Adrenocortical carcinoma in childhood is a rare tumour which accounts for about 0.2% of all paediatric malignancies. Affected children usually present with virilization, cushingoid features, and/or mineralocorticoid excess. We present a boy with adrenal carcinoma presented with virilization and unusually suppressed cortisol at initial presentation.Case report: A two-year-old boy presented with pubic hair, acne, and increased penile growth wit...