Endocrine Abstracts

Background: One in four children in England are now obese by school year 6. Childhood obesity is associated with significant co-morbidity including type 2 diabetes (T2DM), non-alcoholic fatty liver disease (NAFLD), obstructive sleep apnoea (OSA) and depression. NICE guidance suggests consideration of co-morbidity screening in children with body mass index (BMI) >98th centile but BMI does not accurately reflect adiposity in children owing to confounding effects of gender, h...

Background: Glucocorticoid (GC) therapy is standard of care of management of Duchenne Muscular Dystrophy (DMD) but its use is associated with a range of side-effects. Weight gain leading to significant obesity is common in GC-treated boys.Aim(s): To evaluate changes in growth parameters: height-SDS, weight-SDS, body mass index (BMI)-SDS following initiation of GC in DMD.Methods: Between 2013-2019, 26 boys with DMD were commenced on...

Introduction: Evaluating hunger and hyperphagia is an important component of assessing children and young people with obesity. Identifying increased hunger levels will help clinicians and health professionals to taper management aspects including relevant genetic testing and providing tailored dietary and pharmacological management.Aim: The aim of this study was to evaluate the baseline hunger levels in a group of UK adolescents with severe obesity.<...

Introduction: Visceral body fat has been shown to correlate with complications related to obesity. Body mass index (BMI) is widely used to define obesity in the adolescent population; however, it does not take the overall body composition into account. We present body composition data in a group of UK adolescents attending the tertiary MDT weight management service.Methods: Data was collected on 31 patients (M:F = 15:16) attending the MDT service over a ...

Introduction: Up to 70% of adults living with human immunodeficiency virus (HIV) have excessive weight due to side effects of antiretroviral therapy (ART). Liraglutide is a licenced GLP-1 receptor agonist for the treatment of obesity in adolescents. However, there are no studies on effectiveness and safety of GLP-1 receptor agonists in patients on ART as these patients are excluded from most of the clinical trials. Herein, we present a teenage girl with HIV who developed throm...