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Endocrine Abstracts (2022) 85 P32 | DOI: 10.1530/endoabs.85.P32

BSPED2022 Poster Presentations Miscellaneous 1 (7 abstracts)

Service evaluation of girls with complex disability presenting with concerns regarding puberty

Georgia McKinney 1 , Tamsin Groom 2 , Vanessa Mackay 3 , Sze Choong Wong 4 & Avril Mason 4

1University of Glasgow, Glasgow, United Kingdom; 2Department of Sexual and Reproductive Health, Sandyford, Glasgow, United Kingdom; 3Department of Obstetrics and Gynaecology, Queen Elizabeth University Hospital, Glasgow, United Kingdom; 4Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, United Kingdom

Introduction: There are currently no recommendations on the assessment, investigation and follow-up for girls presenting with concerns regarding puberty with background of complex disability who are non-weight bearing.

Aim: Service evaluation (assessment, investigation and follow-up) of girls presenting with any of Central Precocious Puberty (CPP), Early Puberty (EP), Delayed Puberty (DP) or period management with background of immobility in context of complex disability.

Methods: Girls identified from two New Paediatric Endocrine clinics, 2016-2019. Information including age, pubertal status, diagnoses, medication, nutrition and fracture history was collected.

Minimal standards of care were established:

• Height/length, weight and pubertal assessment

• Biochemical assessment of puberty (Follicle Stimulating Hormone [FSH], Luteinising Hormone [LH] and oestradiol)

• Bone age and pelvic ultrasound (CPP/EP/DP only)

• Assessment of bone health (Dual X-ray Absorptiometry [DXA] +/- lateral spine x-ray, vitamin D and bone profile)

Results: 13 girls were included with background of immobility secondary to cerebral palsy (n=6), spina bifida (n=5) or other developmental delay (n=2). Median age was 9.5years (range: 0.9-15.0). Assessment of height/length was recorded in 6/13(46.2%), weight in 9/13(69.2%) and pubertal assessment in 10/13(76.9%) girls. FSH, LH and oestradiol were measured in 10/13(76.9%) girls. Bone age was performed in 7/7(100%) and pelvic ultrasound in 5/7(71.4%) girls presenting with CPP/EP/DP. 5/13(38.5%) girls had an assessment of bone health with either DXA (n=2) or spinal x-ray (n=3). Vitamin D and bone profile was measured in 7/11(53.8%) girls. All 13 girls were followed up at least once with final diagnoses CPP (n=2), EP (n=4), DP (n=1) and period management (n=4). Treatment was commenced in 10/13(76.9%): 7/10(70%) received Gonadotropin Releasing Hormone analogue, 2/10(20%) supplemental oestrogen, 1/10(10%) Tranexamic acid and Mefenamic acid.

Conclusions: A leaflet titled “Managing Puberty in Young Girls with Physical and Learning Disabilities’ was produced to provide information to parents and carers. A proforma was created to guide assessment of puberty and bone health in complex disability.

Volume 85

49th Annual Meeting of the British Society for Paediatric Endocrinology and Diabetes

Belfast, Ireland
02 Nov 2022 - 04 Nov 2022

British Society for Paediatric Endocrinology and Diabetes 

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