Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

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SfE BES is returning to Harrogate in 2022. Join with endocrine specialists from across the UK and beyond for the Society for Endocrinology's flagship meeting.

Basic Physiology Workshops

New advances in neuroendocrinology

ea0086bpw2.1 | New advances in neuroendocrinology | SFEBES2022

How does the brain know what you’ve eaten?

Garcia-Caceres Cristina

The underlying basis for understanding of how brain control energy homeostasis, resides in a functional and coordinate communicating pathways between peripheral endocrine organs and the brain, in which the hypothalamus plays a pivotal role in the integration and processing of peripheral metabolic cues into satiety and feeding signals. Glial cells in particular astrocytes, as being an integral cell type of the neurovascular unit forming direct physical contacts with cerebral b...

ea0086bpw2.2 | New advances in neuroendocrinology | SFEBES2022

New methods to investigate the GnRH pulse generator

O'Byrne Kevin

The neural construct underlying the hypothalamic GnRH pulse generator has only recently been identified despite its elegant electrophysiological manifestation (abrupt increases in multiunit electrical activity volleys invariably associated with LH pulses) described over 40 years ago by Ernst Knobil. Following the identification of the arcuate KNDy (Kisspeptin/Neurokinin-B/Dynorphin) neurones as the critical component of the GnRH pulse generator, direct in-vivo calcium imaging ...

ea0086bpw2.3 | New advances in neuroendocrinology | SFEBES2022

How does the pituitary decode GnRH signals?

Bernard Daniel

Gonadotropin-releasing hormone (GnRH) plays fundamental roles in the control of reproductive physiology. Perturbations in GnRH production or secretion cause infertility or subfertility. GnRH analogs are used clinically to both promote and inhibit the reproductive axis. GnRH is produced in neurons in the hypothalamus and is released in pulses into the pituitary portal system. The hormone binds to its cell surface receptor, GnRHR, on pituitary gonadotrope cells, where it stimula...