Endocrine Abstracts

Abstract Unavailable...

Pituitary adenomas are among the most common brain tumours and can result in significant morbidity (e.g. blindness), reduced quality of life, and death if left untreated. Transsphenoidal surgery is the mainstay of treatment for the majority of symptomatic pituitary adenomas and has the potential to offer a cure. However, many series describe high rates of treatment failure and recurrence - in functioning adenomas (e.g. up to 20% in Cushing’s Disease) and non-functioning a...

Aggressive pituitary tumours (APT) are not controlled by standard therapies. Pituitary carcinomas (PC) share many properties with APT and are defined by the presence of metastases. Temozolomide (TMZ), an oral alkylating with good penetrance into the brain, is the recommended first line chemotherapy. The survival has markedly been improved in patients with APT/PC during the last two decades. Prior to the TMZ-era, 66% of patients with PC were dead within a year after detection o...