Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

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SfE BES is returning to Harrogate in 2022. Join with endocrine specialists from across the UK and beyond for the Society for Endocrinology's flagship meeting.

Early Career and Plenary Orals

Clinical Endocrinology Trust Best Abstract Basic

ea0086ec1.4 | Clinical Endocrinology Trust Best Abstract Basic | SFEBES2022

Characterising the G-protein signalling mechanisms activated by short chain fatty acids in human enteroendocrine cells which mediate production and release of the anorectic gut hormones peptide YY (PYY) and glucagon-like peptide-1 (GLP-1)

Hirdaramani Aanya , Frost Gary , Hanyaloglu Aylin

The anorectic gut hormones glucagon-like peptide-1 (GLP-1) and Peptide YY (PYY) are secreted by enteroendocrine L cells in response to short chain fatty acids (SCFAs) produced by gut microbiota following dietary fibre consumption. SCFAs, acetate, propionate and butyrate, activate the G protein-coupled receptors Free Fatty Acid Receptor 2 and 3 (FFAR2, FFAR3). Increasing intestinal levels of propionate can prevent weight gain in overweight adults. In rodents, FFAR2-mediated gut...