Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

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SfE BES is returning to Harrogate in 2022. Join with endocrine specialists from across the UK and beyond for the Society for Endocrinology's flagship meeting.


Featured Clinical Case Posters

ea0086cc1 | Featured Clinical Case Posters | SFEBES2022

Case report: a rare case of hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome due to heterozygous pathogenic GATA3 alteration

Shafiq Shahriar , Gohil Shailesh , Bhake Ragini , Reddy Narendra , Craft Emily , Lakhani Neeta , Levy Miles

Introduction: Hypoparathyroidism may be an isolated or a component of a complex syndrome. Although genetic disorders are not the most common cause, molecular analyses have identified a growing number of genes that when defective result in impaired formation of the parathyroid glands, disordered synthesis or secretion of parathyroid hormone.Case presentation: We are reporting a 37-year-old gentleman, who is the first adult case diagnosed at our University...

ea0086cc2 | Featured Clinical Case Posters | SFEBES2022

Coexistence of cranial diabetes insipidous and heart failure with reduced ejection fraction: a case report presenting challenges and unique therapeutic opportunities

Efthymiadis Agathoklis , H P Gamble James , Pal Aparna

History: We present the case of a 47-year-old man with heart failure (HF) and cranial diabetes insipidus (CDI) secondary to Langerhans-cell-histiocytosis. In the context of worsening HF with increasing shortness of breath and fluid retention, careful desmopressin dose reduction provided adequate aquaresis to restore euvolemia, obviating the need for usual diuretic treatments.Investigations: Echocardiography and a cardiac MRI revealed a non-dilated but se...

ea0086cc3 | Featured Clinical Case Posters | SFEBES2022

Transient hypophosphatemia secondary to iron infusion

Mistry Kieran , MacEacharn William , Yadav Jahnavi , Mehta Rubin , Mulla Kaenat , Freudenthal Bernard , Avari Parizad , Cox Jeremy , Vakilgilani Tannaz

Hypophosphatemia is commonly missed due to nonspecific signs and symptoms. It can cause muscle weakness, confusion, white blood cell dysfunction and disrupt cardiopulmonary systems. Three main mechanisms of hypophosphatemia are shifts from the extracellular to intracellular compartment, increased renal excretion and decreased intestinal absorption. Here we report a case of symptomatic hypophosphatemia post ferric carboxymaltose (Ferrinject) infusion. A 42 year old lady with lo...

ea0086cc4 | Featured Clinical Case Posters | SFEBES2022

Bilateral adrenalectomy for congenital adrenal hyperplasia: holygrail for infertility?

Riaz Fatima , Mumby Clare , Hanley Neil

This is the case of a now 37 years old female. She was diagnosed with classical salt wasting congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency at 1 week after birth. She highlights the challenges of living with CAH. She struggled all through her childhood and adolescence with the burden of treatment, difficulties with compliance and the effects of the inadequate control of hyperandrogenism. In adulthood supraphysiological doses of exogenous steroids lead to...

ea0086cc5 | Featured Clinical Case Posters | SFEBES2022

Insulinoma induced pseudo-remission of type 1 diabetes

Tellier Genevieve , Wood Ffion , Searell Catrin , Adam Safwaan , Jamdar Saurabh , Wilton Anthony

Insulinomas are neuro-endocrine tumours of the pancreas with an incidence of 0.7-4 cases per 1,000,000 population per year. Type 1 diabetes has an incidence of >20 cases per 100,000 per population per year. Cases of insulinoma with diabetes are lower than in the general population with a type 2 preponderance. This report is the seventh of insulinoma with type 1 diabetes suggesting the latter inhibits the development of the former. A 31 year old female with a 20 year histor...

ea0086cc6 | Featured Clinical Case Posters | SFEBES2022

A rare presentation of avascular necrosis of the femoral head and mild cardiomyopathy in a patient with 17-hydroxylase deficiency

Elamin Aisha , Schini Marian , Eastell Richard , Debono Miguel

Introduction: Avascular necrosis of the femoral head (AVN) is most commonly a consequence of glucocorticoid excess and is believed to be due to osteocyte apoptosis. It can also be due to vascular occlusion or trauma. We describe a patient with congenital adrenal hyperplasia secondary to 17-hydroxylase deficiency who presented with osteoporotic vertebral fractures and atraumatic avascular necrosis of the femoral head. She was also found to have mild cardiomyopathy.<p class=...

ea0086cc7 | Featured Clinical Case Posters | SFEBES2022

Cholestyramine as monotherapy for thyrotoxicosis: experience at a tertiary care centre during COVID-19 pandemic

Iqbal Fizzah , Yin Win , Nijith Lakshmi , Lansdown Andrew , Taylor Peter , Witczak Justyna

Introduction: Thionamides are the mainstay of management of thyrotoxicosis but can be associated with adverse effects like agranulocystosis, hepatitis and vasculitis. While radioactive iodine and thyroidectomy can be utilized in such scenarios, they were not timely available during the COVID pandemic. We present our experience of using cholestyramine as monotherapy.Case Series: Our series consists of four females. Graves’ disease was the underlying ...

ea0086cc8 | Featured Clinical Case Posters | SFEBES2022

Pituitary pseudo-tumour in primary hypothyroidism: early recognition avoids unnecessary pituitary surgery

Tran Anh , Hyer Steve , Johri Nikhil

Presentation: A 20 year old student was brought to the Emergency Department with a 13 day history of heavy menstrual bleeding. On the day of her admission she had collapsed. On admission, she was noted to be pale with severe postural drop (70 mm Hg).Investigations: Haemogobin: 46 g/l. Blood film showed an iron-deficient picture. eGFR: 54ml/min/1.73m2. Creatinine: 124 μ mol/l. Free T4: <5.3 pmol/l. TSH: >500 mU/l. TPO antibodies positive (8.3...

ea0086cc9 | Featured Clinical Case Posters | SFEBES2022

A rare presentation of ovotesticular disorders

M Ratnayake Gowri , Chandana UDS , Chandrasiri Upali , Abeysinghe Chandima , Dassanayake Wajira , Maddumabandara HRL , Liyanage PPS , Ruwanpura Lahiru , Gunatilake Sonali

Introduction: The prevalence of gynaecomastia ranges between 40-60% and the majority of cases are asymptomatic, commoner among obese and is due to excess circulating oestrogen. Ovo-testicular disorders of sex development (OT-DSD) is one of the rarest disorders of DSDs and commonly presents with bilateral intra-abdominal gonads and ambiguous external genitalia.Case presentation: A 15 years old male presented with progressively worsening bilateral gynaecom...

ea0086cc10 | Featured Clinical Case Posters | SFEBES2022

Percutaneous pulmonary valve intervention in severe metastatic mid gut neuroendocrine tumour with carcinoid heart disease (hedinger syndrome): a case report

Karunanayaka Madushani , Bentham Jamie , Parry Helen , Munir Alia

Introduction: Carcinoid heart disease can occur in up to 20 % of patients with carcinoid syndrome. It is a regarded as a rare complication and associated with high morbidity and mortality as a sequela of vasoactive peptides resulting in plaque formation on the valve leaflets classically tricuspid and pulmonary valves and causing right heart failure. Definitive treatment is surgical valve replacement, but percutaneous valve management is an attractive alternative for those deem...