Endocrine Abstracts

Following pituitary or adrenal surgery, an undetectable morning cortisol suggests remission, and the patient needs to be discharged on replacement glucocorticoid, either thrice-daily hydrocortisone (commonly 10mg in the morning, 5 mg at noon and 2.5mg at 4pm) or once-daily prednisolone (commonly 3mg to 4mg)1. Low-dose once-daily prednisolone is seven times more potent than hydrocortisone2. Weaning prednisolone is easier than weaning hydrocortisone3</...

Patients on thyroxine have lower psychological well-being than controls using the GHQ12 questionnaire, which gives patients a score between 0 (very happy and well) and 36 (profoundly exhausted and feeling worthless). Average GHQ was 11.39 in controls and 12.09 in patients optimised on thyroxine(P=0.028)1. Liothyronine has a large and sustained placebo effect with the GHQ improving from 13.5 to 11.0 in the WATTS study2. This placebo effect needs c...

This talk will focus on contraceptive options for patients with polycystic ovary syndrome (PCOS). Key considerations for clinicians will be explored, including the choice of appropriate formulations for cycle regulation, control of symptoms of androgen excess and suppression of dysfunctional menstrual bleeding. Other issues covered during this session will include contraceptive options in patients with obesity or at high risk of complications such as venous thromboembolism, as...

Seventy percent of menopausal women experience vasomotor symptoms (hot flushes and/or night sweats), and 10% will describe them as intolerable, but many will have a contraindication and/or aversion to hormone replacement therapy which is the most effective treatment. Therefore, for those women current treatment options are limited and include herbal remedies, centrally acting modulators of neurotransmitter concentrations (eg SSRIs/SNRIs), clonidine, and cognitive behavioural t...

Hypophosphataemia is a common mineral metabolic abnormality affecting 2-3% of all hospital in patients and up to 34% of ICU patients. The causes are numerous. Over the last two decades following the identification of Fibroblast growth factor-23 (FGF-23) as the phosphaturic hormone responsible for Autosomal Dominant Hypophosphataemic Rickets (ADHR) in 2000 there has been an explosion in the understanding of phosphate homeostatic physiology and disorders of phosphate homeostasis...

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