Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

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SfE BES is returning to Harrogate in 2022. Join with endocrine specialists from across the UK and beyond for the Society for Endocrinology's flagship meeting.

Oral Communications

Metabolism, Obesity and Diabetes

ea0086oc5.1 | Metabolism, Obesity and Diabetes | SFEBES2022

Human brown adipose tissue demonstrates substantial choline uptake for incorporation into phosphatidylcholines

Suchacki Karla , Ramage Lynne , Gray Calum , Rodrguez Blanco Giovanny , Choong Kwok T'ng , Boyle Luke , MacNaught Gillian , Gregoriades Maria-lena , Wakelin Sonia , von Kriegsheim Alex , Finch Andrew , Patel Dilip , van Beek Edwin , Stimson Roland

Background: 18F-fluorodeoxyglucose (18FDG) PET is commonly used to quantify brown adipose tissue (BAT) mass/activity in humans but requires cold exposure. Rodent brown (BAds) but not white adipocytes (WAds) exhibit high choline content, thus we hypothesised that human BAT would demonstrate substantial 18F-fluorocholine (18FCH) uptake in vivo during warm and cold conditions.Methods: (1)...

ea0086oc5.2 | Metabolism, Obesity and Diabetes | SFEBES2022

7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) is a novel AKR1D1 substrate driving metabolic dysfunction and hepatocellular cancer risk in patients with non-alcoholic fatty liver disease (NAFLD)

Nikolaou Nikolaos , Arvaniti Anastasia , Sanna Fabio , da Conceicao Ismael , Dempster Niall , Gathercole Laura , Tomlinson Jeremy

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from intrahepatic lipid accumulation to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Liver 5β-reductase (AKR1D1) catalyses a fundamental step in bile acid (BA) synthesis. BAs and BA intermediates are potent regulators of metabolic and proliferative phenotype. We have hypothesised that AKR1D1 plays a crucial role in NAFLD and HCC. Liver biopsies and serum samples were obtained from healt...

ea0086oc5.3 | Metabolism, Obesity and Diabetes | SFEBES2022

Normothermic machine liver perfusion as a tool to study human androgen metabolism

Anthony Amarah , Clarke George , Schiffer Lina , Fan Yiyu , Hawley James , Shaheen Fozia , Hann Angus , Taylor Angela , Afford Simon , Arlt Wiebke

Background: In women, androgen excess is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). Androgen precursors are released from the adrenal gland and converted to active androgens in peripheral tissues including adipose tissue. Although the liver plays a key role in all metabolic processes in the body, its involvement in androgen metabolism is yet to be explored. Here, we describe the investigation of androgen metabolism in human liver using norm...

ea0086oc5.4 | Metabolism, Obesity and Diabetes | SFEBES2022

New avenues for vertical sleeve gastrectomy-induced diabetes remission mechanisms: kidney-adipose tissue axis

Fanouriou Brisnovali Niki , Doria Durazzo Isabella , Akalestou Elina

Bariatric surgery is known to improve obesity-induced systemic inflammation and glucose homeostasis, however, the exact mechanisms behind this effect are not fully understood. We have previously shown that Sodium Glucose Transporter 2 (SGLT2) is significantly inhibited in the kidney cortex following Vertical Sleeve Gastrectomy (VSG), causing a reduction in renal glucose reabsorption. In this study, we hypothesize that the observed post-operative reduction of SGLT2 is controlle...

ea0086oc5.5 | Metabolism, Obesity and Diabetes | SFEBES2022

Upregulation of hepatic de novo lipogenesis dissociates from changes in liver fat content and insulin sensitivity in healthy humans

Dearlove David , Parry Sion , Johnson Elspeth , Cornfield Thomas , Mozes Ferenc , Dyson Pam , Hodson Leanne

Introduction: Increased hepatic de novo lipogenesis (DNL) is often associated with greater intrahepatic triglyceride (IHTG) content and/or decreased insulin sensitivity; however, the contribution of DNL to each has not been fully elucidated. Therefore, the present work determined if increased DNL, achieved via adoption of an isocaloric high-sugar diet, resulted in concomitant increases in IHTG content and/or decreases in insulin sensitivity.Methods: Sixt...

ea0086oc5.6 | Metabolism, Obesity and Diabetes | SFEBES2022

Labelling and characterisation of somatostatin secreting D-Cells in primary human duodenal organoids culture

Bany Bakar Rula , Sayda Mariwan H. , Smith Christopher A. , Guccio Nunzio , Kay Richard , Gribble Fiona M. , Reimann Frank

Backgrounds and aims: Enteroendocrine cells (EECs) are hormone-secreting cells within the intestinal epithelium that play an important role in regulating food absorption, insulin secretion and appetite. The somatostatin (SST)-producing D-cell is an EEC of particular interest due to the profound inhibition exerted by SST over other EECs, highlighting D-cells as critical regulator of the enteroendocrine axis. The aim of this study was to profile the transcriptom...