Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

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SfE BES is returning to Harrogate in 2022. Join with endocrine specialists from across the UK and beyond for the Society for Endocrinology's flagship meeting.

Oral Communications

Reproductive and Neuroendocrinology

ea0086oc3.1 | Reproductive and Neuroendocrinology | SFEBES2022

Depot somatostatin receptor ligand therapy reverses tissue thyrotoxicosis in thyrotropinomas and aids microadenoma localization via 11C-Methionine PET

Koulouri Olympia , MacFarlane James , Bashari Waiel , Gillett Daniel , Senanayake Russell , Halsall David , Oddy Sue , Powlson Andrew , Serban Laura , Moran Carla , Schoenmakers Nadia , Chatterjee Krishna , Gurnell Mark

Context: Surgery is the first-line treatment option for thyrotropinomas, but medical therapy with somatostatin receptor ligands (SRL) may be used as neoadjuvant treatment and to facilitate safe surgery.Objectives: To determine the extent to which neoadjuvant SRL (i) corrects clinical, laboratory and tissue hyperthyroidism in thyrotropinomas, (ii) induces tumour shrinkage in macroadenomas, and (iii) aids microadenoma detection by 11C-methionine...

ea0086oc3.2 | Reproductive and Neuroendocrinology | SFEBES2022

BRF1-mediated paracrine signalling from pituitary stem cells is required for terminal differentiation of pituitary committed progenitors

Willis Thea L , Manshaei Saba , Reen Virinder , Pallikonda Husayn , Birch Jodie , Yianni Val , Lodge Emily J , Withers Dominic , Gil Jesus , Martinez-Barbera Juan Pedro , Andoniadou Cynthia L

The pituitary gland is a critical endocrine organ regulating multiple essential physiological processes including growth, reproduction, metabolism and the stress response. Hormone-producing pituitary cell lineages are derived from a population of embryonic precursors expressing the transcription factor SOX2. These cells maintain multipotency into early postnatal life, acting as the resident population of pituitary stem cells (PSCs) and contributing to all the endocrine cell li...

ea0086oc3.3 | Reproductive and Neuroendocrinology | SFEBES2022

Long-term efficacy and safety of oral, once-daily paltusotine treatment in acromegaly: Two-year interim results from the ACROBAT Advance study

Randeva Harpal , Gadelha Monica , Gordon Murray , Doknic Mirjana , Mezősi Emese , Toth Miklos , Boguszewski Cesar , Ferrara-Cook Christine , Casagrande Alessandra , Krasner Alan

Paltusotine is an investigational oral, once-daily, non-peptide, SST2 agonist in development for the treatment of acromegaly and neuroendocrine tumors. Interim analysis results from subjects with acromegaly treated with paltusotine for up to 2 years in ACROBAT Advance (NCT04261712), an ongoing, open-label extension study are reported here. Prior to Advance, subjects previously completed one of two Phase 2 parent studies, Evolve (NCT03792555, with normal IGF-1 using injected lo...

ea0086oc3.4 | Reproductive and Neuroendocrinology | SFEBES2022

Maternally derived pancreatic extracellular vesicle miR-375 contributes to large-for-gestational-age infants in pregnancies complicated by gestational diabetes

Quilang Rachel , Byford Abigail , Scott Eleanor M , Forbes Karen

Pregnancies affected by GDM commonly result in large-for-gestational-age (LGA) infants, which have an increased risk of developing cardiometabolic complications. The mechanisms responsible are unclear but are associated with altered placental physiology. We have previously reported that miRNAs, including pancreatic specific miR-375, are altered in maternal serum extracellular vesicles (EVs) prior to the onset of LGA, and in term placenta. We assessed maternal pancreatic-derive...

ea0086oc3.5 | Reproductive and Neuroendocrinology | SFEBES2022

Radiomics as a tool for risk stratification of non-functioning pituitary adenomas following primary surgery

MacFarlane James , Gillett Daniel , Koulouri Olympia , Bashari Waiel , Casey Ruth , Gurnell Mark

Background: Existing biomarkers have limited ability to discriminate indolent non-functioning pituitary adenomas (NFPAs) from those with a propensity to recur following primary surgery. Radiomics, the extraction of quantitative data from medical imaging, is increasingly recognised as a tool to augment clinical decision making.Methods: 39 patients who underwent primary trans-sphenoidal surgery for an NFPA between January 2007 and April 2017, were enrolled...

ea0086oc3.6 | Reproductive and Neuroendocrinology | SFEBES2022

Kisspeptin enhances sexual and attraction brain processing in women with low sexual desire

Thurston Layla , Hunjan Tia , Ertl Natalie , Wall Matthew , Mills Edouard , Suladze Sofiya , Patel Bijal , Alexander Emma , Muzi Beatrice , Bassett Paul , Rabiner Eugenii , Bech Paul , Goldmeier David , Abbara Ali , Comninos Alexander , Dhillo Waljit

Hypoactive sexual desire disorder (HSDD) is a persistent lack of sexual desire, causing marked interpersonal distress. It is the most common global female sexual health problem, although the precise pathophysiology remains uncertain. Existing treatment options are limited by their efficacy and side effects. The neuropeptide kisspeptin offers a potential therapeutic target given its emerging role in modulating reproductive behaviour. Using a combination of psychometric, neuroim...