Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

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SfE BES is returning to Harrogate in 2022. Join with endocrine specialists from across the UK and beyond for the Society for Endocrinology's flagship meeting.

Oral Poster Presentations

Metabolism, Obesity and Diabetes

ea0086op4.1 | Metabolism, Obesity and Diabetes | SFEBES2022

The effects of a tripeptide hormonal infusion on sweet taste function and eating behaviour

Behary Preeshila , Alessmii Haya , Miras Alexander , Tharakan George , Alexiadou Kleopatra , Purkayastha Sanjay , Moorthy Krishna , R Ahmed Ahmed , Bloom Stephen R , Tan Tricia M

Background: Roux-en-Y Gastric Bypass (RYGB) results in sustained weight loss. Changes in food preferences and eating behaviour are postulated as possible contributing mechanisms. Post-RYGB, patients consume less sugary and fatty food. Sweet taste detection and sensitivity have been reported to be enhanced post-surgery and this may account for changes in the palatability of food. Underlying mechanisms for the changes in sweet taste function and eating behaviour are unclear....

ea0086op4.2 | Metabolism, Obesity and Diabetes | SFEBES2022

Differential effects of L- and D-lactate on HCAR1 signalling

Milner Annabelle , Brown Alastair , Frost Gary , Hanyaloglu Aylin

Lactate is a metabolite that activates the G-protein coupled receptor, Hydroxycarboxylic acid Receptor 1 (HCAR1) to regulate physiological processes such as lipolysis, cancer cell survival, and neuroprotection. Lactate exists in two forms, L+ and D-, with the L isoform predominant in the human body. Interestingly, both isoforms are only found together in the gastrointestinal tract. L-lactate is synthesised as a by-product of anaerobic respiration, whereas D-lactate, is a produ...

ea0086op4.3 | Metabolism, Obesity and Diabetes | SFEBES2022

miR-10b is an essential regulator of adipogenesis

Kalenderoglou Nikoletta , Christian Mark

Determining the sequence of events controlling preadipocyte commitment and subsequent terminal differentiation into adipocytes is critical to gain insight into brown and white fat physiology and metabolic dysfunction. MicroRNAs (miRNAs) are important regulators of gene expression and emerging evidence supports their involvement in adipogenesis and adipose metabolism. The aim of this study is to 1) identify miRNAs that modulate differentiation or function of white and brown adi...

ea0086op4.4 | Metabolism, Obesity and Diabetes | SFEBES2022

iPSC-derived hepatocytes as a novel tool for glycogen storage disease 1A (GSD1A) modelling and drug screening

Nikolaou Nikolaos , Aksoy Melissa , Cheung Ka , Chung Samuel , Heslop James , Gil Carlos , Panman Lia

Glycogen storage disease 1A (GSD1A) is an inherited metabolic disorder caused by glucose-6-phosphatase (G6PC) deficiency. Patients with GSD1A present disturbed glucose homeostasis and exhibit glycogen accumulation accompanied by hepatomegaly, hypoglycemia, lactic acidosis and hyperlipidemia. However, there are currently no licensed treatments for GSD1A, and human in vitro systems for disease modelling and drug screening are lacking. We aimed to develop a human hepatoc...