Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 86 | SFEBES2022 | Next issue

Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

Card image cap
SfE BES is returning to Harrogate in 2022. Join with endocrine specialists from across the UK and beyond for the Society for Endocrinology's flagship meeting.

Poster Presentations

Reproductive Endocrinology

ea0086p117 | Reproductive Endocrinology | SFEBES2022

Quantifying the Variability in the Outpatient Assessment of Reproductive Hormone levels

Adams Sophie , Voliotis Margaritis , Phylactou Maria , Izzi-Engbeaya Chioma , Mills Edouard , Thurston Layla , Hanassab Simon , Tsaneva-Atanasova Krasimira , Heinis Thomas , Comninos Alexander , Abbara Ali , Dhillo Waljit

Background: Due to practical limitations, the diagnosis of hypogonadism is predominantly based on a single measure of reproductive hormones, often with confirmation on a second occasion. Factors associated with reproductive hormone variation include: pulsatile secretion, diurnal rhythm, and food intake, which can affect the accuracy of diagnosis of reproductive disorders. There is limited data quantitatively estimating the variability of reproductive hormone levels over the da...

ea0086p118 | Reproductive Endocrinology | SFEBES2022

Determining the impact of FSH glycosylation variants on the pre-antral follicle transcriptome in the ageing ovary

Johnson Gillian , Bousfield George , Jonas Kim

Ovarian ageing is a naturally occurring physiological process, marked by dynamic changes in ovarian function and hormone secretion. A key of ovarian regulator is follicle stimulating hormone (FSH). FSH is secreted as two glycosylation variants: partially glycosylated FSH (FSH21) and fully glycosylated FSH (FSH24). Analysis has shown that the ratio of FSH21:FSH24 changes with age, with FSH21 predominant during reproductive prime, and FSH24 predominant around menopause. How FSH ...

ea0086p119 | Reproductive Endocrinology | SFEBES2022

FSH glycosylation variants differentially modulate FSHR trafficking

Agwuegbo Uche , Richardson Rachel , Albert Anthony , Hanyaloglu Aylin , Jonas Kim

The Class A G protein-coupled receptor (GPCR), follicle-stimulating hormone receptor (FSHR), and its associated heterodimeric glycoprotein hormone (FSH) are essential for reproduction. As such, they’re key targets of assisted conception. Post-translational modification of FSH gives rise to two predominant glycosylation variants, which are modulated with ageing: partially glycosylated FSH (FSH21/18), predominates in women’s reproductive prime (20’s), displays fas...

ea0086p120 | Reproductive Endocrinology | SFEBES2022

Female reproductive health disturbance associated with the COVID-19 pandemic persists despite improving mental health- a longitudinal observational study

Lonergan Eibhlin , Maher Michelle , Collier Sonya , Ann Behan Lucy , Phelan Niamh , Hevey David , Owens Lisa

Background: The COVID-19 pandemic has adversely affected population mental health. In April 2021 we conducted an observational study which demonstrated disruption in women’s reproductive and mental health during the first year of the pandemic. Our objective therefore was to perform follow up studies in this cohort of women at 6-monthly intervals, to assess the longer term enduring impact of the pandemic on reproductive and mental health.Materials/Me...

ea0086p121 | Reproductive Endocrinology | SFEBES2022

Tool development for the in vivo analysis of the physiological role of FSHR oligomerisation

Johnson Gillian , Hopkins Thomas , Agwuegbo Uche , Bousfield George , Jonas Kim

G protein-coupled receptors are the largest family of mammalian receptors, with key roles in controlling most physiological processes. Ovarian function is no exception, with a key ovarian GPCR, follicle stimulation hormone receptor (FSHR), and its endogenous ligand, FSH, critical for pre-antral-antral follicle growth and survival. An increasingly important way that GPCRs have been shown to regulate ligand specificity and signal amplitude is via association and formation of dim...

ea0086p122 | Reproductive Endocrinology | SFEBES2022

Are elevated red blood cell parameters coincidental or correlated in patients with Turner syndrome?

D S A Dilrukshi M , Beck K , Roy N , Turner H E

Introduction: Long-term increased morbidity and mortality in Turner Syndrome (TS) due to vascular disease is recognized, and suggested risk factors include metabolic parameters and possible change in haemostasis, however elevated red cell parameters in women with TS have not previously been noted.Methods: Following an observation of unexplained occurrence of elevated hemoglobin, a quality improvement-project was conducted to retrospectively review full b...

ea0086p123 | Reproductive Endocrinology | SFEBES2022

Androgen receptor splice-variants in granulosa-lutein cells of women with polycystic ovary syndrome (PCOS)

Anujan Priyanka , Lerner Avi , Owens Lisa , Markou Andrea , Hardy Kate , Hanyaloglu Aylin , Bevan Charlotte , Franks Stephen

Defects in any of the four functional domains of the androgen receptor (AR) (resulting from loss-of-function or gain-of-function mutations), may affect androgen action. Specific AR splice variants have been reported in women with PCOS (Wang et al, PNAS 2015 112 4743). In this study we sought to identify AR splice variants in granulosa-lutein (GL) cells of women with and without PCOS and to assess their functional significance. GL cells were ...

ea0086p124 | Reproductive Endocrinology | SFEBES2022

Divergent G-protein signal control at the very early endosome (VEE) from the dually coupled luteinizing hormone receptor (LHR)

Richardson Rachel , Sposini Silvia , Yildiz Yoldas , Barlow Lucy , Hanyaloglu Aylin

Membrane trafficking of G-protein coupled receptors (GPCRs) is a critical mechanism by which cells mediate complex signaling pathways. Endosomes are increasingly recognized as platforms for GPCR signaling. The VEE was first identified using the LHR, a GPCR that is key in reproduction. We have shown that recycling of the LHR is driven by receptor mediated Gαs cAMP signaling from the VEE and PKA-dependent phosphorylation of the adaptor protein, APPL1, while APPL1 negatively...

ea0086p125 | Reproductive Endocrinology | SFEBES2022

Simulation via Instant Messaging - Birmingham Advance helps to narrow the gap of knowledge and expectations between clinicians and women with polycystic ovary syndrome: A SIMBA-PCOS mixed-method study

Melson Eka , Rezai Fatema , Synn Cuen Pan Carina , Sheikh Jameela , Kaur Harjeet , Cooper Catherine , Abdelhameed Farah , Pang Francesca , Bhatt Shreya , Shabbir Dania , Zhou Dengyi , Davitadze Meri , Gleeson Helena , Manolopoulos Konstantinos , Chu Justin , O'Reilly Michael , Arlt Wiebke , Gillett Caroline , Kempegowda Punith , behalf of SIMBA Team On

Introduction: Educational interventions for healthcare professionals (HCPs) in diabetes and endocrinology often limits patient and public involvement (PPI). We studied the effectiveness of Simulation via Instant Messaging-Birmingham Advance (SIMBA) as a tool to improve knowledge about polycystic ovary syndrome (PCOS) in HCP and women with PCOS. Additionally, we aimed to identify and reduce gaps in knowledge and expectations between HCP and women living with PCOS.<p class="...

ea0086p126 | Reproductive Endocrinology | SFEBES2022

Experience of Prescribing Testosterone Gel to Menopausal Women at a Single UK Centre: The Biochemistry and The Patent Experience

Heald Adrian , Naseem Asma , Keatley Claire , Duran Beatriz , Cortes Moreno Gabriela , Panay Nick

Introduction: It has been suggested that sexual dysfunction affects as many as 43% of women in the population. In relation to this, symptoms of hypoactive sexual desire disorder (HSDD) can be alleviated with testosterone replacement.Aim: To determine what is the pre- and 24-hour post dose circulating level of testosterone in women applying Testogel 16.2 mg/g.Methods: In a group of 10 menopausal women applying Testogel 16.2 mg/g at ...

ea0086p127 | Reproductive Endocrinology | SFEBES2022

Interleukin-6 increases at the onset of lactation and promotes mammary glycolysis: insights from clinical and cellular studies

Meng Xin , Rostom Hussam , Humphrey Robert , Fry Alexandria , Elajnaf Taha , Hannan Fadil

The onset of lactation occurs during postpartum days 1-4 and is associated with altered mammary metabolism leading to increased milk component synthesis. We hypothesised that increases in metabolic hormones or cytokines after childbirth may support these processes. To investigate this, we recruited n=12 pregnant women following informed consent and measured: prolactin; thyroid-stimulating hormone; insulin; cortisol; insulin-like growth factor-1; and interleukin-6 (IL-...

ea0086p128 | Reproductive Endocrinology | SFEBES2022

Therapeutic Mechanism of Aqueous Extract of Momordica Against Monosodium Glutamate Induced Ovarian Toxicity

Alege Pelumi , Arietarhire Leviticus

Background: Monosodium glutamate (MSG) use for food addictive have become quite alarming taken together with the huge reports of its toxic effects in the different organ of the body. Thus, this study demonstrates the therapeutic potentials of Mc on MSG-induced ovarian toxicity in female Wistar rats.Methods: A total of 28 female rats (weight=165&pm;3g) were randomly assigned into 4 groups (A – D, n=7) and treated orally as follows: A – ...

ea0086p129 | Reproductive Endocrinology | SFEBES2022

Adipocytes-Derived Extracellular Vesicle-miR-26b Induces the process of Polycystic Ovary Syndrome

Zhou Guannan , Gu Yuanyuan , Zhou Fangyue , Hua Keqin , Ding Jingxin

Background: Adipocyte cells could produce numerous extracellular vesicles and orchestrate the balance of endocrinological system. Polycystic ovary syndrome (PCOS) is a refractory reproductive disease and also a kind of endocrine and metabolic disease. The aim of the study was to explore the effects of adipocyte-derived extracellular vesicles-miR-26b on cumulus cells (CCs) and development of PCOS.Methods: The crosstalk mediated by extracellular vesicle-mi...

ea0086p130 | Reproductive Endocrinology | SFEBES2022

Turner Syndrome - a case report illustrating the importance of early gynaecology input for women who are unable to tolerate progestins

Oo Win , Poole Ruth , Hillard Tim , Webster Daniel , Snape Sonya , Richardson Tristan , Page Georgina , Holt Helen

A 41-year-old woman with primary ovarian failure secondary to Turner syndrome presented in December 2020 with heavy vaginal bleeding. She had not attended appointments during the Covid-19 epidemic because of concerns around contracting the virus. She was anaemic with haemoglobin 47g/dl. Ultrasound showed grossly thickened and heterogenous endometrium (60 mm). Cross sectional imaging and hysteroscopy confirmed locally advanced endometrial carcinoma (Stage 3). She proceeded to h...

ea0086p266 | Reproductive Endocrinology | SFEBES2022

Identification of a transcription factor that modulates ERα-Dependent Hypothalamic Estrogen Sensing

Fernandes-Freitas Isabel , Milona Alexandra , Ramos-Pittol Jose , Manchishi Stephen , Rainbow Kara , Lam Brian , Tadross John , Beucher Anthony , Colledge William , Cebola Ines , Murphy Kevin , Miguel-Aliaga Irene , Yeo Giles , Dhillo Waljit , Owen Bryn

Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It is thought to require estrogen to have simultaneous positive and negative feedback effects on two spatially-distinct regions of the hypothalamus, the arcuate nucleus and ‘AVPV’ nucleus. However, the mechanistic basis for this differential effect is not known. Therefore, we mapped the genomic binding of the estrogen receptor alpha (ERα) in bot...

ea0086p267 | Reproductive Endocrinology | SFEBES2022

Spatial and ligand-directed control of Prostaglandin EP2 signalling

Walker Abigail , Parkin Holly , Woodward David , Hanyaloglu Aylin

Prostaglandin E2 acts via 4 GPCRs, EP1-4. EP2 regulates inflammation and has important roles in cardiovascular function, reproduction, and malignancy. GPCR signalling and trafficking are highly integrated as signals from the endomembrane can exhibit distinct profiles from the plasma membrane. Whether EP2 activity is spatially regulated and if this is modified by ligand bias is currently unknown. In HEK 293 cells, three selective EP2 ligands, butaprost, AH13205, and PGN9856i, e...

ea0086p268 | Reproductive Endocrinology | SFEBES2022

Cluster analysis with routine hormonal parameters identifies two distinct subsets of polycystic ovary syndrome (PCOS)

Deshmukh Harshal , Akbar Shahzad , Bhaiji Amira , Saeed Yamna , Shah Najeeb , Batten Lucy , Adeleke Kazeem A , Atkin Stephen , Sathyapalan Thozhukat

Introduction: Women with PCOS have a higher risk of metabolic syndrome and cardiovascular complications. We aimed to understand if routinely measured hormonal parameters can identify women with PCOS with a higher risk of metabolic syndrome (MetS).Methods: The data for the study consisted of a discovery cohort (PCOS clinic database) and a replication cohort (Hull PCOS Biobank.) We used eight routinely measured hormonal parameters in our clinics (free andr...

ea0086p269 | Reproductive Endocrinology | SFEBES2022

Metformin Exposure In-Utero Influences Placental Pathways Associated with Mitochondrial Activity

Owen Manon , Hugh Katie , Quilang Rachel , Scott Eleanor , Forbes Karen

Metformin is a first-line therapy for type-2 diabetes mellitus and gestational diabetes mellitus (GDM) which shows significant benefits for maternal health. However, offspring exposed to metformin in-utero have an increased risk of being born small for gestational age and developing cardiometabolic complications in adulthood. The mechanisms responsible are unknown. As fetal growth is dependent on optimal placental function, we assessed whether metformin exposure alter...

ea0086p270 | Reproductive Endocrinology | SFEBES2022

How do endocrinologists and GPs perceive contemporary transgender care?: results from a qualitative study of UK doctors

Franklin Jonathan , Thakur Apoorva , Patel Vinod

Background: A growing number of people in the United Kingdom are seeking medical treatment to align their sexual characteristics with their gender identity. With waiting lists for specialist clinics currently lasting over four years, endocrinologists are increasingly called upon to manage transgender care as part of their general duties. While surveys and qualitative studies from North America have investigated doctors’ ideas and experiences of transgender care, little is...

ea0086p271 | Reproductive Endocrinology | SFEBES2022

Relationships between adipocyte fatty acid-binding protein with parameters of obesity in women with polycystic ovary syndrome

Polak Aleksandra , Łebkowska Agnieszka , Krentowska Anna , Buczyńska Angelika , Krętowski Adam , Kowalska Irina , Adamska Agnieszka

Introduction: Adipocyte fatty acid binding protein (A-FABP) is mainly expressed in adipocytes, and circulating A-FABP has been associated with markers of obesity. Women with PCOS are at increased risk of developing abdominal obesity what could be related to serum concentration of A-FABP.Aim: The aim of the present study was to investigate the relationships between serum concentration of A-FABP and parameters of obesity e.g. waist to hip ratio (WHR) and t...

ea0086p272 | Reproductive Endocrinology | SFEBES2022

Vernonia amydalina leaf extract ameliorates hyperandrogenism and oxidative stress in polycystic ovarian syndrome-induced Sprague-Dawley rats

Abimbola Ogunsola Oluseyi , Alabi Great

Polycystic ovarian syndrome (PCOS) is a common endocrine and gynaecological disorder, occurring in 5% to 20% women of reproductive age. It is characterized by hyperandogenism, ovulatory dysfunction and polycystic ovaries. Impaired hypothalamic-pituitary-ovarian axis, insulin resistance and oxidative stress are identified causal mechanisms of PCOS. Vernonia amydalina(VA) leaf is a medicinal plant containing bioactive phytochemicals known to improve insulin sensitivity....

ea0086p273 | Reproductive Endocrinology | SFEBES2022

Interleukin-15, a pleiotropic cytokine, is increased in the mammary gland during lactation

Robinson Maya , Allen Lois , Asteljoki Juho , Rostom Hussam , Meng Xin , Stewart Michelle , Elajnaf Taha , Hannan Fadil

Lactation promotes infant development and confers long-term health benefits to mothers and infants. However, the endocrine and paracrine mechanisms mediating milk synthesis remain to be fully elucidated. Hormones such as prolactin and progesterone trigger the onset of lactation, whereas local mammary factors are considered to play a greater role in the maintenance of milk synthesis. We hypothesised that mammary epithelial cytokines are required for established lactation, and u...

ea0086p274 | Reproductive Endocrinology | SFEBES2022

Investigating hormones triggering the onset of sustained lactation (INSIGHT) pilot study

Fry Alexandria , Rostom Hussam , Price Helen , Archer Amy , Hilier Emily , Meng Xin , Elajnaf Taha , Humphrey Robert , Guha Nishan , James Tim , Kennedy Stephen , Hannan Fadil

The onset of human lactation is characterised by increased breast fullness and the start of copious milk secretion. The process, which typically occurs 1-4 days postpartum, is triggered by a decrease in serum progesterone and high prolactin concentrations, although the exact levels are ill-defined. We aim to establish reference intervals for hormones triggering the onset of sustained lactation and understand how breastfeeding influences hormone secretion, so as to improve the ...

ea0086p275 | Reproductive Endocrinology | SFEBES2022

Follicle Sizes That are Most Likely to Yield Oocytes During In Vitro Fertilisation (IVF) Treatment

Alhamwi Toulin , Abbara Ali , Hanassab Simon , Comninos Alexander , Kelsey Tom , Salim Rehan , Heinis Thomas , Dhillo Waljit

Background: Infertility affects 1 in 6 couples causing devastating psychological impact. In vitro fertilisation (IVF) treatment can aid couples to conceive, but personalisation of treatment is needed to optimise patient outcomes. Machine learning can aid in the analysis of large complex datasets such as those encountered during IVF treatment. One example is in determining the optimal follicle size on the day of trigger to maximise the number of oocytes collected. Both follicle...

ea0086p276 | Reproductive Endocrinology | SFEBES2022

Is there a consensus for Management of Hormone Replacement for Males and Females with Hypogonadism in the UK? SfE national survey

Al-Sharefi Ahmed , Quinton Richard , Turner Helen E

Background: Optimization of sex hormone replacement therapy (SHRT) is essential in long-term management of patients with hypogonadism. However, approaches to formulations of therapy, dose change (if any), monitoring of adequacy of therapy and safety are not standardised.Objectives: The survey aimed to establish the approach to management of SHRT for male and female hypogonadism.Methods: Online survey, live for 4 weeks (1/11/2021) d...

ea0086p277 | Reproductive Endocrinology | SFEBES2022

Comparative analysis of the fertility-enhancing potentials of graded doses of Newbouldia laevis and Zinc in male Wistar rats

Adana Misturah , Adebayo Adewale , Aina Samuel , Queen Nathan

Infertility has become a real public health problem because of its increasing prevalence, widespread distribution, and the difficulties inherent in its management. Male factor infertility is thought to be the cause of up to 50% of all infertilities across the world. In some parts of Africa and from time immemorial, a wide variety of plants are of great medicinal importance. Many plant extracts have been used as fertility agents in folklore and traditional medicines to enhance ...

ea0086p278 | Reproductive Endocrinology | SFEBES2022

Severe Virilization due to ovarian hyperthecosis

Wellala Vindya , Bulugahapitiya Uditha

Approximately 10% of the female present with features of hyperandrogenism in their life. It is common in adolescent and childbearing age and less common in menopausal age. A 56-year-old female with a history of type 2 diabetes mellitus, hypertension presented with progressively worsening features of virilization for 1 year. Patient had severe hirsutism, androgenic alopecia and clitoromegaly. She had no loss of weight, loss of appetite suggestive of underlying malignancy. Howev...

ea0086p279 | Reproductive Endocrinology | SFEBES2022

Growth hormone therapy in the management of short stature due to turner syndrome in Nigeria: a case report

Ede Obiamaka , Olopade Oluwarotimi , Odeniyi Ifedayo , Fasanmade Olufemi

Introduction: Turner Syndrome (TS) is the most common chromosomal abnormality affecting phenotypic females. Short stature (SS) is one of the most consistent clinical features of TS, with consequent poor psychosocial outcomes. Management involves early diagnosis and administration of recombinant human growth hormone (rhGH). The cost of therapy however hampers treatment in resource-challenged regions. The objective of this presentation is to report the outcome and challenges of ...

ea0086p356 | Reproductive Endocrinology | SFEBES2022

The impact of body mass index and lifestyle factors on serum concentrations of reproductive and thyroid hormones in premenopausal women

O'Neill Helen , Rodrigues Vaz Sofia , Vasavan Tharni , Moreton Emily , Ni Dhonnabhain Brid , Lawrie Lucinda , Getreu Natalie

The impact of BMI, exercise, smoking, drug and alcohol use on reproductive and thyroid hormones has little or conflicting evidence. We therefore aimed to investigate the association between these factors and serum hormone concentrations. Capillary blood samples were taken from 932 eumenorrheic Hertility Health users on menstrual cycle day 3 between Sept 2020 and June 2022. Serum concentrations of Anti-Müllerian hormone, Estradiol (E2), Luteinising Hormone (LH), Follicle-S...

ea0086p357 | Reproductive Endocrinology | SFEBES2022

The rapeutic potentials of Vernonia amygdalina in letrozole and high-fat diet induced polycystic ovary syndrome in female wistar rats

Adebodun Great , Ogunsola Abimbola , Raji Yinusa

Polycystic ovary syndrome (PCOS) is an endocrine disorder that is common among women in their reproductive ages. This condition is associated with insulin resistance, oxidative stress, hormonal imbalance, and inflammation. Various drugs are used in treating this disorder but with side effects, hence the need for an alternative treatment with minimal side effects. This study was aimed at investigating the effect of methanol extract of Vernonia amygdalina on the reprodu...

ea0086p358 | Reproductive Endocrinology | SFEBES2022

The reproductive years: the experience of women attending routine diabetes care

McDonnell Tara , O'Connor Aisling , Cussen Leanne , Madden Doyle Lauren , Forde Hannah , Smith Diarmuid , O'Reilly Michael W.

Reproductive morbidity is increased in women with diabetes, including a higher prevalence of polycystic ovary syndrome, hypothalamic amenorrhoea and premature ovarian failure. Routine discussion of reproductive and menstrual dysfunction for women with diabetes remains a peripheral feature of clinical consultations. Here we aimed to determine women’s own reproductive care experience. We surveyed women of all ages attending routine diabetes care using a detailed clinical qu...

ea0086p359 | Reproductive Endocrinology | SFEBES2022

A rare case of male infertility; XX male syndrome

A H Mohamed Areej , Hutchinson Ben , Baig Irfan

Introduction: The XX male syndrome occurs in 1 in 20,000 births. This syndrome results from crossover between the X and Y chromosomes, which transfers the sex-determining region of the Y chromosome to the X chromosome. They lack the azoospermia factor region of the Y chromosome, which is essential for spermatogenesis; thus causing infertility.Case Description: 34-year-old gentleman was referred to endocrinology clinic for infertility and semen analysis s...

ea0086p360 | Reproductive Endocrinology | SFEBES2022

Reduced accuracy of gold top blood collection tubes for reproductive hormone profiling in capillary blood samples

Getreu Natalie , Vasavan Tharni , Timpson Adrian , O'Neill Helen

While evidence of concordance between reproductive hormone measurements in venipuncture and capillary serum exists, variation between blood collection tubes has not been investigated. We compared the performance of two capillary and venipuncture blood collection tubes (red and gold top) and assessed variation between two leading tube manufacturers. To compare tube types, venipuncture and finger prick capillary samples were concurrently collected from 11 premenopausal women in ...

ea0086p361 | Reproductive Endocrinology | SFEBES2022

Genomic imprinting and maternal adaptations to pregnancy

Charalambous Marika , Scagliotti Valeria , Esse Ruben , Amarsi Risha , Lillina Vignola Maria

In late pregnancy the mother must mobilise considerable energy stores to support fetal growth. Failure to appropriately nourish the fetus has significant obstetric consequences – gestational diabetes and fetal growth restriction (FGR). Despite this, relatively little is known about how metabolic responses are stimulated in the mother, and how they may go wrong. We previously found that high levels of the product of an imprinted gene, Delta-like homologue-1 (D...

ea0086p362 | Reproductive Endocrinology | SFEBES2022

Clinical utility of GnRH analogues in female androgen excess: diagnostic and therapeutic implications

Madden Doyle Lauren , Cussen Leanne , McDonnell Tara , O'Reilly Michael W

Rare causes of severe androgen excess (AE) can present a diagnostic challenge to endocrinologists. Imaging may not identify occult ovarian pathology, and the detection of adrenal nodular disease may be indicative of incidental pathology. GnRH analogues can be used both as a medical treatment and as a diagnostic utility to confirm ovarian source, particularly in women with a preferential elevation of serum testosterone (T). In this case series, we present three cases highlighti...

ea0086p363 | Reproductive Endocrinology | SFEBES2022

Turner Syndrome with 45X gene presenting with Menorrhagia: A diagnostic dilemma

Jegavanthan Dhulashiha , Naveenan Antonypillai Charles , Sanas Mohamed Ramjan

Turner syndrome (TS) is the most common chromosomal anomaly in females and its occurrence is about 1:4000 live births. This is the only monomer disease that humans can survive (1). It is characterized by the presence of one X chromosome and a partial or complete loss of the second X chromosome. Clinical features of TS can vary, mainly classified into Growth failure, gonadal insufficiency, cardiovascular diseases, or learning disabilities. Short stature is the only phenotypic a...