SFEBES2022 Poster Presentations Adrenal and Cardiovascular (66 abstracts)
Mapping the chromatin-associated-lncRNAs and their enhancer regions between lymphatic and endothelial cells
Tijana Mitic 1 , Emma Chaloner 1 , Chenyun Zhang 1 , Tatiana Dudnakova 1 & Hywel Dunn-Davies 2
1Queen’s Medical Research Institute, Edinburgh, United Kingdom; 2Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
Blood vessels supply nutrients, oxygen and other key molecules necessary for the function of all organs in the body. The endothelial cell (EC) repair and response to injury or hypoxia is also regulated by the interplay of chromatin-modifying enzymes. Likewise, dysregulation of the lymphatic system underlies the development of the metabolic syndrome. New technologies using omics approaches have now allowed the detection of chromatin and RNA molecules that directly interact in normoxic or disease states. We utilised such approaches to explore the chromatin remodelling in maintenance of two types of primary ECs. We compared the epigenetic landscape as well as chromatin bound RNA:RNA species between the cultured human primary dermal lymphatic and blood vascular ECs. We generated a comprehensive database of human long non-coding RNAs (lncRNAs) that regulate functionality and genome structure through association with chromatin, and the particular enhancer regions specific to each cell types. Thus, our study provides molecular framework for therapeutic targeting of RNA-associted genomic regions in individual vascular beds that associate with various metabolic conditions.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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