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Endocrine Abstracts (2022) 86 P326 | DOI: 10.1530/endoabs.86.P326

SFEBES2022 Poster Presentations Metabolism, Obesity and Diabetes (96 abstracts)

Examining the relationship between gestational diabetes, maternal pre-pregnancy body mass index (BMI) and large for gestation age neonates by ethnicity

Pei Chia Eng , Chiara Veidi , Edward Mullins , Jayne Terry , Bryony Jones , Anne Dornhorst , Chukwuma Uduku , Lynne Sykes , Christina Yu , Stephen Robinson & Rochan Agha-Jaffar

Imperial College London, London, United Kingdom

Objective: To determine if the impact of pre-pregnancy body mass index (BMI), fasting glucose levels and post load glucose levels on large for gestational age neonates varies with ethnicity.

Data sources: Electronic health records of all eligible pregnant women in an inner city service. Study designRetrospective analysis of pregnant women at risk of developing gestational diabetes mellitus (2016-2019) of. Population or sampleEligible pregnant women. Synthesis methodMaternal and fetal characteristics were compared across five ethnic groups: White, Black African-Caribbean, South Asian, Mixed/Other Asian and other/Unknown. A customized birth centile calculator was used to determine prevalence of LGA in each ethnic group by category of maternal BMI, fasting glucose and 120-minutes plasma glucose. Association between fetal macrosomia and maternal BMI, fasting and 120-minutes plasma glucose were assessed across ethnic groups using multilinear regression analyses (with White ethnicity as the reference group).

Results: Among the 16788 participants, 36.8% were women of white origin, 21.8% Black African Caribbean, 8.8%South Asian, 20.9% Mixed origin and 12.1% originated from other ethnic groups. Mothers of Black and African Caribbean, South Asian and Mixed origin delivered a higher proportion of LGA neonates at low pre pregnancy maternal BMI categories (< 18.5) and high BMI categories (only for black).

Conclusions: Ethnicity influences percentage of large for gestational age neonates. Glucose threshold to define LGA risk differs in each ethnic groups. Ethnic specific glucose threshold to define LGA could be indicated.

Volume 86

Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

Society for Endocrinology 

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