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Endocrine Abstracts (2022) 86 P330 | DOI: 10.1530/endoabs.86.P330

SFEBES2022 Poster Presentations Metabolism, Obesity and Diabetes (96 abstracts)

Glicentin concentrations following Liraglutide treatment in patients with overweight/obesity

Wiaam Al-Hasani 1 , Ruvini Ranasinghe 1 , James Luxton 1 , Tracey Mare 1 , Georgios K Dimitriadis 2,3,4 & Royce P Vincent 1,3

1Clinical Biochemistry Department, King’s College Hospital, London, United Kingdom; 2Endocrinology Department, King’s College Hospital, London, United Kingdom; 3School of Life Course Sciences, King’s College London, London, United Kingdom; 4Warwick Medical School, University of Warwick, Coventry, United Kingdom

Background: Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist that promotes weight loss. The minimum adequate/good response to liraglutide (≥5% weight loss at 3 months) is not achievable in all patients. Currently there are no biomarkers to predict good response. Enhanced postprandial glicentin concentration was recently considered as superior to GLP-1 in predicting weight loss following bariatric surgeries.

Objective 1) To assess the effect of liraglutide on fasting glicentin concentration in patients with overweight/obesity 2) To evaluate the difference in baseline fasting glicentin concentrations between good and poor responders to liraglutide (≥5% vs. <5% weight loss from baseline).

Methods: Validation of glicentin ELISA kit (Mercodia, Sweden) was performed and fasting glicentin concentrations from 34 patients collected at baseline (pre-treatment), 2, 4 and 6 months post treatment were analysed. Statistical analysis was done using Analyse-It v5.40.2. T-test was used to examine the difference between baseline and post-treatment glicentin concentrations. ANOVA-test was used to examine the difference in baseline glicentin between good and poor responders. Level of significance is 5%.

Results: Glicentin concentration decreased following liraglutide (mean difference -11.8 mmol/l, 95% CI: -18.1 to-4.16, P: 0.001) There was no difference in glicentin between good and poor responders at baseline (n=17 in each group).

Conclusion: Liraglutide treatment is associated with a significant reduction in fasting glicentin concentration. Possible explanation is that liraglutide can downregulate glicentin in a manner similar to endogenous GLP-1. Larger studies maybe needed using both fasting and postprandial samples (where glicentin concentration is higher) to better assess the clinical utility of glicentin as a predictor of good weight loss response to liraglutide.

Volume 86

Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

Society for Endocrinology 

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