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Endocrine Abstracts (2022) 86 S6.3 | DOI: 10.1530/endoabs.86.S6.3

SFEBES2022 Symposia Novel therapeutics and diagnostics in adrenal disease (3 abstracts)

New applications of steroid metabolomics to adrenal tumours

Alessandro Prete 1,2

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1Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom. 2Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom


Steroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in even more detail, by the 24-hour urine steroid metabolome, which can provide unique insights into alterations of steroid flow and output indicative of underlying conditions. Mass spectrometry-based steroid metabolome profiling has allowed for the identification of unique steroid signatures associated with disorders of steroid biosynthesis and metabolism that can be used for personalised approaches to diagnosis, differential diagnosis, and prognostic prediction. Machine learning is uniquely suited to analyse high-complexity datasets and its application to the wealth of information generated through steroid metabolome profiling has facilitated the development of powerful customised diagnostic approaches. This talk will provide an overview of the utility of steroid metabolome analysis for the diagnosis and management of autonomous adrenal steroid excess in the context of adrenal tumours. Topics covered will include early diagnosis of adrenal cancer and its recurrence, the diagnosis and risk stratification of cortisol excess, and the diagnosis and subtype classification of aldosterone excess.

Volume 86

Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

Society for Endocrinology 

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