Endocrine Abstracts

Adrenal incidentalomas (AI) are recognized more and more frequently, due to the widespread use of CT. Although unexpected, these tumors raise the question of a putative morbidity related either to their proliferation potential or to their endocrine secretion. Regarding proliferation it is now established that a low (<10 UH) and homogeneous density on unenhanced CT scan is specific for a benign adrenocortical adenoma, which do not need to be operated for fear that they may ...

Background: Adrenocortical carcinoma (ACC) is a rare cancer associated with hereditary syndromes in 10% of cases. However, data on germline variants (GVs) in adult patients with sporadic ACC are limited.Methods: We analyzed germline DNA from 150 adult patients with sporadic ACC sequentially referred to our centers between 1998-2019. We designed a custom panel of 17 genes potentially involved in the pathogenesis of ACC: AIP, APC, ARMC5, ARNT, BRCA1, BRCA2...