Cervical paragangliomas: clinical presentation and Managment modalities

Houas Jihene; Kechiche Jawaher; Ghammam Monia; Lazid Sarra; Malika El Omri; Bellakhhder Mouna; Yosra Hasni El Abed; Meherzi Abir; Kermani Wassim; Abdelkefi Mohamed

doi:10.1530/endoabs.90.EP641

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Endocrine Abstracts (2023) 90 EP641 | DOI: 10.1530/endoabs.90.EP641

ECE2023 Eposter Presentations Endocrine-related Cancer (80 abstracts)

Cervical paragangliomas: clinical presentation and Managment modalities

Houas Jihene ¹ , Kechiche Jawaher ¹ , Ghammam Monia ¹ , Lazid Sarra ¹ , El Omri Malika ¹ , Bellakhhder Mouna ¹ , Hasni El Abed Yosra ² , Meherzi Abir ¹ , Kermani Wassim ¹ & Abdelkefi Mohamed ¹

Err

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¹ENT Department and Neck Surgery of Farhat Hached Hospital, Sousse, Tunisia; ²Endocrinology Department Farhat Hached Hospital, Sousse, Tunisia.

Introduction: Paragangliomas are a diverse group of neuroendocrine tumors arising from chromaffin cells within paraganglionic tissues of the autonomic nervous system.

The aim of this study is to review our experience in the management of these tumors.

Methods: The medical records of 12 patients with 13 paraganliomas was performed in a a single academic hospital over a period of 32 years from 1990 to 2022.

Results: There were 10 women (83.3%) and 2 men (16.6%) with a mean age of 47 years. A painless lateral neck mass was the main finding in 10 cases. There was no evidence of a functional tumor. Computed tomography was performed in 8 cases and MRI in 11 cases. The majority of the lesions were paragangliomas of the carotid bifurcation (7 cases), while 5 patients with a vagal paraganglioma. Bilateral vagal paragangliomas were detected in one case. Secretory activity was studied in 6 patients. All patients had normal level of metanephrines. For patients treated with radiotherapy, Radiotherapy was able to control growth in all treated tumors. 8 patients treated surgically. The most commonly affected structures were the facial nerve, the vagus nerve and the hypoglossal nerve and Sympathetic chain palsy as a sequela of the surgery. Average follow-up time was 36 monthes and there were no regional recurrence.

Conclusion: Surgery and radiation therapy represent the main treatment modalities for paraganglioma. Although surgical resection has remained the mainstay of treatment for paragangliomas, the need for preoperative embolization remains controversial. Secretory and malignant tumors are extremely rare and requires active management.