Searchable abstracts of presentations at key conferences in endocrinology
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25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

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ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

Eposter Presentations

Endocrine-related Cancer

ea0090ep579 | Endocrine-related Cancer | ECE2023

Mathematical model for preoperative differential diagnosis for the parathyroid neoplasms

Krupinova Julia , Elfimova Alina , Kim Ekaterina , Eremkina Anna , Maganeva Irina , Kovaleva Elena , Mokrysheva Natalia

Backgrounds: Preoperative diagnosis of parathyroid carcinoma (PC) is critical for the determination of the scope of surgical intervention. Nowadays, specific diagnostic markers for differentiation of PC and benign tumors are unknown, and less than half of patients with PC undergo necessary en bloc surgery.Aims: To develop the instrument for preoperative diagnosis of PC.Materials and methods: A multi-center retrospective study inclu...

ea0090ep580 | Endocrine-related Cancer | ECE2023

Real world efficacy and safety of multikinase inhibitors in patients with advance differentiated thyroid cancer

Duenas-Disotuar Suset , Manuel Canelo-Moreno Juan , De Lara-Rodriguez Irene , Romero-Lluch Ana , Navarro-Gonzalez Elena

Purpose: To establish the safety and efficacy of multikinase inhibitors (MKIs) treatment in real life.Methods: This retrospective observational descriptive study included patients with advanced differentiated thyroid cancer in treatment with MKIs as first and second line treatment. From November 2011 to May 2022. Clinical variables, efficacy and adverse events (AE) were collected. Variables are expressed as median and interquartile range.<p class="ab...

ea0090ep581 | Endocrine-related Cancer | ECE2023

A rare association of glucagonoma and gastric gastrinoma

Ben Rebai Senda , Rojbi Imen , Mekni Sabrine , Sawsen Essayah , Ben Nacef Ibtissem , Khiari Karima

Introduction: Glucagonomas are rare functioning pancreatic neuroendocrine tumours that secrete glucagon. Gastrinomas are neuroendocrine tumours that secrete gastrin and are rarely located in the stomach. We report an extremely rare case of concomitant gastric gastrinoma and glucagonoma.Case presentation: A 64-year-old-man with a history of digestive haemorrhage and gastrectomy presented with weight loss, asthenia, anorexia and abdominal pain. Esophagogas...

ea0090ep582 | Endocrine-related Cancer | ECE2023

Clinical characteristics and survival of patients with functional lung neuroendocrine tumors

Popovic Bojana , Ognjanovic Sanja , Ilic Dusan , Elezovic Kovacevic Valentina , Opalic Milica , Radic Lena , Micev Marijan , P. Macut Djuro

Aim: Functional neuroendocrine tumors (NETs) represent a specific diagnostic and therapeutic challenge. Hormonal clinical syndrome can severely complicate clinical picture and affect treatment. Functional pancreatic NETs have been extensively studied. Our aim was to analyze functional lung NETs in terms of clinical characteristics and survival.Materials and methods: We retrospectively analyzed data from 230 patients with lung NETs treated at our departme...

ea0090ep583 | Endocrine-related Cancer | ECE2023

Recurrent parathyroid cancer in a child associated with mutation in CDC73 gene

Kim Ekaterina , Krupinova Julia , Eremkina Anna , Kalinchenko Natalya , Mokrysheva Natalia

Background: Parathyroid cancer (P?) in children is extremely rare, more often sporadic, but may be associated with a germline mutation. The only effective treatment is surgical approach due to the chemo-radio-resistance of PC.Clinical case: A 6-years-old girl presented with weakness, gait disturbance, pain in the limbs, an X-shaped curvature of the legs. At the age of 12, the patient’s well-being worsened sharply. The laboratory examination revealed...

ea0090ep584 | Endocrine-related Cancer | ECE2023

Patient-derived three-dimensional model of papillary thyroid cancer for personalized medicine and testing of novel therapies

Petrova Daria , Bastrich Asya , Abilov Zaur , Bondarenko Ekaterina , Urusova Liliya , Nikiforovich Petr , Belcevich Dmitry , Pylina Svetlana , Eremkina Anna , Kim Ekaterina , Mokrysheva Natalia

Introduction: Over the last decades, there has been a significant increase in the incidence of thyroid cancer. Papillary thyroid cancer (PTC) is the most common histopathological type with often a favorable prognosis. Conventional therapies include surgical resection, adjuvant therapy with radioactive iodine, and suppressive therapy with thyroid hormones. However, the prognosis for iodine-resistant/refractory thyroid cancers or the advanced metastatic cancer is less favorable....

ea0090ep585 | Endocrine-related Cancer | ECE2023

Phenotypic presentation of MEN1 (NM_130799.2):c.758delC (p.Ser253CysfsTer28) rs1592648765 pathogenic mutation of MEN-1 gene: a case report

Vergani Edoardo , Concolino Paola , Traini Emanuela , Macis Giuseppe , Mancini Antonio

Multiple endocrine neoplasia (MEN) 1 is a rare hereditary autosomal dominant tumor syndrome characterized by two or more endocrine tumors. Non-endocrine neoplasms have been described as well. MEN1 is caused by inactivating mutations of the onco-suppressor gene MEN-1 (chromosome 11q13) which encodes the protein menin. Currently, 897 public variants of MEN-1 gene are reported. We present the case of a recently discovered pathogenic mutations of MEN-1 gene. A 32-year-old Italian ...

ea0090ep586 | Endocrine-related Cancer | ECE2023

Parathyroid carcinoma in a patient with both MEN1 and RET mutations

Pylina Svetlana , Kim Ekaterina , Bondarenko Ekaterina , Krupinova Julia , Eremkina Anna , Mokrysheva Natalia

Background: MEN1-related primary hyperparathyroidism (PHPT) characterised by benign course, whereas malignant transformation is extremely rare. The diagnosis of parathyroid carcinoma (PC) within the MEN-1 syndrome is a challenge for a range of specialists.Clinical case: A 47-year Eastern European female. PHPT had been revealed during examination for multinodular goitre: PTH 614 nmol\l, calcium 3.06 mmol\l. Results of imaging methods were controversial (m...

ea0090ep587 | Endocrine-related Cancer | ECE2023

Prognostic impact of the tumor immune microenvironment in adrenocortical cancer

Pachuashvii Nano , Urusova Liliya

Background: Adrenocortical carcinoma (ACC) is an uncommon endocrine malignancy, usually characterized by a late detection, aggressive clinical course, and poor outcome. The tumor microenvironment (TME) which includes infiltrating immune cells plays a critical role in tumor growth, survival, and prognosis in cancer patients. The presence of tumor-infiltrating immune cells (TIIC) affect the clinical benefit from novel strategies of immunological checkpoint blockade. Anti-immune ...

ea0090ep588 | Endocrine-related Cancer | ECE2023

An unusual association of a familial MEN1 with renin co secretion form a glucagonoma

Mihai Daniel , Ramona Poalelungi , Badiu Corin

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder consisting in the development of primary hyperparathyroidism (PHPT), pancreatic neuroendocrine tumors, and pituitary adenomas. Occurrence of glucagonoma in MEN1 patients is rare (3%) and metastatic disease is present in 50% to 80% of patients at the time of diagnosis. The association of adrenal nodules/tumors and MEN1 is also rare.Case report: We present the case o...

ea0090ep589 | Endocrine-related Cancer | ECE2023

Alpelisib-induced severe hyperglycemia: A case report. Are we discontinuing the drug too soon?

Garcia Fernandez Javier , Perera Izquierdo Marcos

Background: Alpelisib is an α-selective PI3K inhibitor indicated for the treatment of postmenopausal women and men with hormone receptor-positive (HR+), human epidermal growth receptor 2-negative (HER2–), PIK3CA-mutated locally advanced or metastatic breast cancer following disease progression or after endocrine therapy. Hyperglycemia is the most common adverse event (up to 60%) associated with its use. It occurs more frequently and lasts longer in patients with pred...

ea0090ep590 | Endocrine-related Cancer | ECE2023

Incidental diagnosis of MEN2a in a patient with concurrent ovarian carcinoma presenting with cervical lymphadenopathies

Pena Catalina , Sucaliuc Alina , Mircea Ghemigian , Iulian Brezean , Nicoleta Dumitru Alida , Daniel Grigorie

Introduction: Multiple endocrine neoplasia type 2A is an autosomal dominant disorder which is characterized by the occurrence of medullary thyroid carcinoma in association with pheochromocytoma and parathyroid tumors.Case report: We present the case of a 64-year-old woman, with familial history of thyroid carcinoma, renal lithiasis and personal history of right nephrectomy for renal lithiasis, who presented for the investigation of a left lateral cervica...

ea0090ep591 | Endocrine-related Cancer | ECE2023

The correlation between baseline calcitonin levels and the risk of metastasis in patients followed for medullary thyroid carcinoma

Raki Nezha , Essabah Haraj Nassim , El Aziz Siham , CHADLI Asma

Introduction: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that represents the most aggressive form of thyroid carcinoma, usually diagnosed at advanced stages. Serum calcitonin (CT) is the sensitive and specific marker of sporadic and hereditary CMT. It is a diagnostic, prognostic and follow-up marker.Purpose of the study: To investigate the correlation between the risk of metastasis and CT levels at the time of diagnosis of MTC.<p cla...

ea0090ep592 | Endocrine-related Cancer | ECE2023

Ferroptosis in human adrenocortical cells and aldosterone-producing adenomas

Pang Yingxian , Tetti Martina , Gong Siyuan , Reincke Martin , Ann Williams Tracy

Background: The role of ferroptosis – a regulated form of cell death – in the pathophysiology of aldosterone-producing adenomas (APA) is unclear.Objective: To identify mechanisms of ferroptosis in human adrenal cells and translate these findings to APA pathophysiology.Methods: Cell death detection, lipid ROS generation and mRNA sequencing were performed on HAC15 cells treated with the specific ferroptosis inducer RSL3 (1,...

ea0090ep593 | Endocrine-related Cancer | ECE2023

Endocrinopathies in oncological patients treated with immunotherapy: A real world data study

Angelousi Anna , Karampela Athina , Kazanas Spyridon , Papalexis Petros , Lafioniatis Alexandros , Siampanopoulou Vasiliki , Mytareli Chrysoula , Theochari Maria , Stephanou Dimitra , Ziogas Dimitrios , Gogas Helen

Background: Immune checkpoint inhibitors (ICIs) (anti-CTLA-4, PD-1 inhibitors, PD-L1 inhibitors) are considered a widely used therapeutic choice for several cancer types. However ICI therapy is frequently complicated by adverse events; endocrine toxicities are the most common ones.Methods: To assess in a retrospective observational study in a tertiary hospital the incidence and the characteristics of the immunotherapy-related endocrine adverse events (ir...

ea0090ep594 | Endocrine-related Cancer | ECE2023

Psychiatric disorders in Cushing’s syndrome and impact on follow-up

Ouhessaine Sofia , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Cushing syndrome (CS) is a rare and serious disease with high mortality. Diagnosis and management of the disease are difficult, as CS is typically characterized by the presence of multiple symptoms hypertension, diabetes, weight gain, or osteoporosis, the psychiatric and neurocognitive consequences are just as important by a set of anxio-depressive disorders resounding on the quality of life but also on the management of the disease.Objecti...

ea0090ep595 | Endocrine-related Cancer | ECE2023

Immune checkpoint inhibitors induced endocrinopathies: a possible indicator of improved survival

Ornelas Mariana , Borges-Canha Marta , Gouveia Pedro , Maria Morna Ferreira Margarida , Resende Eduarda , Santos Sa Elena Maritza Pontes , Silvestre Abreu Francisco

Background: Immune checkpoint inhibitors (ICI) are an innovative oncologic therapy used in several types of solid and hematological neoplasms. This treatment enables the antitumoral immune system response and results in significant improvement of clinical outcomes and survival rate. However, endocrine related adverse effects (ERAE) have been related, with thyroid and pituitary dysfunction being the most common endocrine diseases described. An association between the surge of e...

ea0090ep596 | Endocrine-related Cancer | ECE2023

Case Report: Successful treatment of an atypical lung neuroendocrine neoplasm with PRRT

Guerreiro Vanessa , Lucena Ines , Paula Santos Ana , Prospero Ines , Ferreira Goncalo , Gil Santos Sara , Oliveira Joana , Freitas Paula , Torres Isabel , Duarte Hugo

Neuroendocrine neoplasms (NENs) arise from specialized cells called neuroendocrine cells spread through the body, mainly in the gastrointestinal tract, pancreas and lung. Pathological classification of Lung NENs include well differentiated NENs, that can be classified as typical or atypical carcinoids, and poorly differentiated neuroendocrine carcinomas (NECs), classified as small-cell lung carcinoma (SC-NEC) or large-cell neuroendocrine carcinoma (LC-NEC). We present a case o...

ea0090ep597 | Endocrine-related Cancer | ECE2023

Diagnostic efficacy of tumor markers in the detection of metastatic pancreatic neuroendocrine neoplasms

Rosiek Violetta , Zemczak Anna , Londzin-Olesik Magdalena , Kos-Kudła Beata

Introduction: Neuroendocrine neoplasms (NENs) are rare heterogenous tumors which prevalence is increasing. Functional pancreatic neuroendocrine neoplasms (p-NENs) develop characteristic clinical syndromes in contrast to non-functional tumors that are diagnosed accidentally or at an advanced stage due to the lack of sensitive and specific biomarkers that could predict their clinical course.Aim: This study aimed to assess tumor markers (TMs) in patients wi...

ea0090ep598 | Endocrine-related Cancer | ECE2023

Adverse events to mitotane therapy in adrenocortical carcinoma

Pascual-Corrales Eider , Ruz-Caracuel Ignacio , Alonso-Gordoa Teresa , Molina-Cerrillo Javier , Araujo Castro Marta

Introduction: : Adrenocortical carcinoma (ACC) is a rare tumor, often with an unfavorable prognosis. The management of ACC is challenging due to its low frequency and limited experience. The objective of this study was to describe the adverse events (AE) in patients diagnosed with ACC treated in the Divisions of Endocrinology and Oncology at the Ramón y Cajal University Hospital (Madrid, Spain) in the last seven years.Methods: Records of patients wi...

ea0090ep599 | Endocrine-related Cancer | ECE2023

Treatment with 177Lu-dotatate in metastasic advanced neuroendocrine tumors with positive expression of somatostatin receptors, in a third level hospital in Spain from 2015–2022

Giron Giselle , Hernandez Lorena , ISABEL DEL OLMO GARCIA MARIA , Camara-Gomez Rosa , Bello Pilar , Prado Stephan , Segura Angel , Francisco Merino Torres Juan

Introduction: 177Lu-Oxodotreotide(PRRT-Lu) has the approval by EMA and FDA since 2017 for the treatment of patients with gastro-entero-pancreatic neuroendocrine tumors(GEP-NET). However, in daily clinical practice it has also been used in other NET tumors such as paragangliomas, lung NET, medullary thyroid cancer, and others. The aim of this study is to describe the characteristics and follow-up of patients treated with PRRT-Lu in a third level hospital in Spain fro...

ea0090ep600 | Endocrine-related Cancer | ECE2023

Experience with variants of the SDH gene related to paraganglioma in the Southern Health Area of Seville (Spain)

Antonio Ariza Jimenez Jose , Arturo Cuellar Lloclla Eyvee , Fernandez Pena J. Ignacio

Introduction: Paragangliomas are rare tumors originated from extraadrenals chromaffin cells. Most are sporadic, but between 30% and 50% are associated with hereditary syndromes. Mutations in the succinate gene dehydrogenase (SDH) have been identified as a cause of the hereditary paraganglioma-pheochromocytoma syndrome.Material and methods: Descriptive study of case series of patients belonging to the Southern Health Area of Seville with mutations in the ...

ea0090ep601 | Endocrine-related Cancer | ECE2023

An Oestrogen-secreting neuroendocrine tumour in the lung

Shah Najeeb , Thow Jonathan

Case: A 59-year-old female with a past medical history of surgically treated primary hyperparathyroidism (PHPT) and breast cancer presented with irregular periods, post-menstrual bleeding, hot flushes, fatigue, and left loin pain. Furthermore, she reported weight gain of approximately 8 lb over 6 months and easy bruising in the absence of antiplatelet and anticoagulant therapy. There were no central, respiratory, or gastrointestinal symptoms. She was normotensive, and the clin...

ea0090ep602 | Endocrine-related Cancer | ECE2023

Revision of the histopathological examination following 68 Ga DOTA-FAPI-04 PET/CT of a Neuroendocrine breast tumor diagnosed as Invasive Ductal Carcinomatosis initially

Sonmez Omer , Akcay Kaan , Beydağı Gamze , Alan Selcuk Nalan , Hacıhasanoğlu Ezgi

Neuroendocrine tumors (NETs) of the breast are very rare. They represent less than 1% of breast carcinomas. It is important to differentiate metastatic neuroendocrine neoplasia from primary neuroendocrine neoplasia of the breast. Histopathological misinterpretation of a breast NET is common. In a study of 18 NET cases that metastasized to the breast, it was found that 62% of these tumors originated from the gastrointestinal tract and 28% from the lung. Forty-four percent of th...

ea0090ep603 | Endocrine-related Cancer | ECE2023

Clinicopathological Features of Insulinoma case series

Sozen Mehmet , Canturk Zeynep , Selek Alev , Cetinarslan Berrin , Huri Eryılmaz Baldan , Gezer Emre , Koksalan Damla

Introduction: Insulinoma is the most common functional pancreatic neuroendocrine tumor (PanNET), accounting for more than 50% of all cases. Diagnosis of insulinomas may be challenging. In this study, we aim to discuss the clinicopathological features and long-term follow-up results of insulinoma cases followed up in our clinic.Material and Methods: It is a descriptive and retrospective study of 13 insulinoma cases diagnosed over 10 years. All data of the...

ea0090ep604 | Endocrine-related Cancer | ECE2023

An unusual etiology of primary hyperparathyroidism in a young woman

Tutoveanu Dan Alexandru , Simona Dragomir Adina , Roxana Boanţă Dana , Simona Dumitraşcu Anda , Ioachim Dumitru

Introduction: Parathyroid carcinoma represents a very rare cause of primary hyperparathyroidism. It can be sporadic (most of cases), but also can occur in association with certain syndromes (multiple endocrine neoplasia, hyperparathyroidism-jaw tumor syndrome or isolated familial hyperparathyroidism).Case report: An 18-year-old woman was referred to the endocrine clinic because of a severe hypercalcemia, detected in the orthopedic surgery department, whe...

ea0090ep605 | Endocrine-related Cancer | ECE2023

Pitfalls in diagnosis and treatment of parathyroid cancer

Druzhkova Nataliya , Dulesova Anastasiia , Afanasieva Zinaida

Introduction.: Parathyroid carcinoma (PC) is the one of the rarest endocrine malignances and occurs in 0.5–5% of cases among patients with primary hyperparathyroidism (PHPT). Diagnosis of PC can be challenging and often made after surgery or while local or distant metastases detection. We present a case of a patient with a large intrathyroid PC, which was initially identified as a malignant thyroid nodule.Case report.: 59-old caucasian women was dia...

ea0090ep606 | Endocrine-related Cancer | ECE2023

Leydig Cell Tumor – a Case of Postmenopausal Hirsutism

Kamashidze Koba , Peshkova Tamar , Jashi Liana , Dundua Ketevan

Background: Progressive hirsutism and moderate to severe male-pattern balding in women requires exclusion of an adrenal or ovarian tumor.Case Presentation: A 51-year-old lady presented with excessive hair on her face and lower abdomen of 1 year duration which affected her quality of life. Her menopause started 3 years ago. Her body mass index was 28.6 kg/m2. She had hair on her upper lip, chin, and lower abdomen; she had a Ferriman–Gallwe...

ea0090ep607 | Endocrine-related Cancer | ECE2023

Extra-adrenal adrenocortical cancer (ACC) associated with multiple endocrine neoplasia type 1

Green Deirdre , Thompson Chris , Hill Arnold , O'Reilly Michael , Sherlock Mark

Adrenocortical carcinoma (ACC) is a rare malignant tumour arising from the adrenal cortex, with an estimated annual incidence of one to two patients per million. Ectopic ACCs are extremely rare. They are believed to arise from cortical fragments arrested during embryologic migration and have been found close to the adrenal gland or along the path of gonadal descent. The majority of ACCs are sporadic, however, ACC has been linked with genetic disease processes, including multip...

ea0090ep608 | Endocrine-related Cancer | ECE2023

Mesenteric paraganglioma with a late-onset metastases accelerated after delayed surgery

Rzepka Ewelina , Minasyan Mari , Przybylik-Mazurek Elwira , Ulatowska-Białas Magdalena , Opalinska Marta , Sowa-Staszczak Anna , Gilis-Januszewska Aleksandra , Hubalewska-Dydejczyk Alicja

Mesenteric paragangliomas are a rare entity; consequently, 20 cases have been reported to date. Although often found incidentally and considered benign, they have potential to metastasize. We present a case of 63-year old man with a 11-year history of the mesenteric paraganglioma. The lesion for the first time had been described on CT scan of the abdomen in 2010. However, the patient was lost to follow-up. In 2021 CT scan, followed by MRI of the abdomen, perfomed due to reccur...

ea0090ep609 | Endocrine-related Cancer | ECE2023

Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of pancreas with typical insulinoma presentation

Serranito Maria Salome , Cunha Nelson , Vigia Duarte Emanuel , Silva-Nunes Jose

IntroductionMixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of the pancreas are composed of two morphologically different components, each representing at least 30% of the tumor: ductal or acinar adenocarcinoma and neuroendocrine neoplasm (NEN). They are extremely rare tumors whose etiopathogenesis and biological behavior are not fully understood. Given its rarity, we describe a case of insulinoma in the context of MiNEN....

ea0090ep610 | Endocrine-related Cancer | ECE2023

Pulmonary metastases in differentiated thyroid cancer

Amel Rahal , Azzouz Samira , Benabed Lynda

Introduction: The incidence of thyroid cancers is increasing; they are considered to have a very good prognosis with good survival The frequency of metastases is 5 to 10%. The most common locations are lung and bone. The morbidity of metastatic disease is related to the initial histological type, tumour mass, location of metastases, age, possible loss of iodine uptake and 18F-FDG uptakeMaterials and methods: We collected 25 patients treated for hormone-d...

ea0090ep611 | Endocrine-related Cancer | ECE2023

Body Mass Index and sporadic Medullary Thyroid Cancer: insights from a large series

Prete Alessandro , Gambale Carla , Cappagli Virginia , Bottici Valeria , Elisei Rossella , Matrone Antonio

Introduction: An increased Body Mass Index (BMI) has been associated with higher prevalence of many cancers, including differentiated thyroid cancer. However, no data have been reported about potential impact of BMI on aggressiveness of presentation and clinical outcome of medullary thyroid cancer (MTC).Aim: To evaluate the potential influence of BMI on clinical presentation and outcome of MTC.Methods: We reviewed anthropometric an...

ea0090ep612 | Endocrine-related Cancer | ECE2023

A new pathogenic variant of MEN 1 gene causing pituitary, pancreatic, parathyroid, adrenal and middle ear neuroendocrine tumors

Schipor Sorina , Stancu Cristina , Stanca Oana , Muresan Andrei , Gherghe Mirela , Badiu Corin

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by germline mutations of MEN1 gene, without genotype–phenotype correlation. It is defined as the occurrence of two or more primary neuroendocrine tumors (parathyroid, enteropancreatic, pituitary), or the occurrence of one of the MEN1-associated tumors in family members of a patient with a clinical diagnosis of MEN1. Multiple parathyroid tumors with hyperparathyroidism are the most common m...

ea0090ep613 | Endocrine-related Cancer | ECE2023

A Rare Case; Ectopic ACTH Syndrome Caused by Metastatic Germ Cell Tumor

Meletli Ozlem Kanburoglu , Birinci Cigdem , Bilginer Cuneyt , Coskun Hulya , Nuhoglu Irfan , Ucuncu Ozge , Kocak Mustafa

Introduction: Although ectopic ACTH syndrome (EAS) is most commonly seen in cancers with neuroendocrine differentiation, it is not a common condition in germ cell tumors. Here we report a rare case of EAS due to metastatic germ cell tumor.Case report: A 53-year-old male patient presented with fatigue, weakness, swelling in both legs and weight loss for 3 months. He had type 2 diabetes and no history of smoking or alcohol. In the physical examination, the...

ea0090ep614 | Endocrine-related Cancer | ECE2023

Pan-endocrine cancer pattern of somatic mutations: Toward Genotype–Phenotype correlation and machine learning methods

Zhang Liang , Crona Joakim

Background: Neuroendocrine tumors (NETs) and Adrenocortical carcinomas (ACCs) are rare and heterogeneous tumors entities. Advanced NETs and ACC own poor prognosis with less than 40% of five-year survival. There is a need for improved biomarkers to predict disease prognosis and treatment sensitivity. A broad overview of NETs and ACC genetics has never been explored.Aim: To investigate genotype–phenotype correlations on a pan-endocrine cancer level wi...

ea0090ep615 | Endocrine-related Cancer | ECE2023

A case report – Should we start breast cancer screening earlier in the MEN-1 patients?

Pina Henrique , Dinis Martins Joao , Duarte Vitoria , Guerra Silvia , Maria Aragues Jose , Valadas Cristina

Multiple endocrine neoplasia type 1 (MEN-1) is characterized by an increased predisposition to the development of tumors of the endocrine tissues, such as parathyroid glands, anterior pituitary, and duodenopancreatic neuroendocrine tumors. It is an autosomal dominant disorder due to germline mutations in the MEN-1 tumor suppressor gene. This gene encodes the menin protein, which is involved in cell growth and differentiation, and in sensing or repairing DNA damage. We present ...

ea0090ep616 | Endocrine-related Cancer | ECE2023

Posterior reversible encephalopathy syndrome (PRES) as a presentation of a metastatic pheochromocytoma (PHEO)

Collao Simone Furio , Blanco Urbaneja Irune , Soledad Librizzi Maria , Mattei Isabella , Jimenez Lopez Noemi , Carrasco Barria Ruben , Chavez Villegas Alvaro Mauricio , Calatayud Gutierrez Maria

Introduction: PRES it’s a neurologic syndrome with multiple manifestations, that includes high blood pressure with a variable range. It usually develops in the context of medications or an underlying condition. The treatment is usually symptomatic and determined by said disease.Objective: We present the case of a patient with PRES linked to the diagnostic of a metastatic PHEO.Case-report: A 72-year-old male underwent left adre...

ea0090ep617 | Endocrine-related Cancer | ECE2023

Molecular predictors of response to the therapy with mitotane in adrenocortical cancer

Porubayeva Erika , Selivanova Lilia

Background: Adrenocortical cancer (ACC) therapy is characterized by insufficient effectiveness. Currently, mitotane, an adrenolytic drug, is the only drug approved for treatment of ACC and is used in the adjuvant setting and in case of metastatic or advanced disease. However, the administration of mitotane to certain groups of patients remains controversial due to the low response rates, high toxicity and limited data on the benefit of treatment. Expression levels of the large...

ea0090ep618 | Endocrine-related Cancer | ECE2023

Merkel cell carcinoma, experience of a single center

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Kovacevic Valentina , Opalic Milica , Radic Lena , P. Macut Djuro

Introduction: Merkel cell carcinoma is a rare and aggressive neuroendocrine skin cancer. It is characterized by a high rate of local recurrence after surgical resection as well as the occurrence of distant metastases. It mostly occurs in the elderly and the exact etiology is unknown. The most significant risk factors for its occurrence are exposure to ultraviolet light and the oncogenic effect of the Merkel cell polyoma virus.Aim: Demographic and clinica...

ea0090ep619 | Endocrine-related Cancer | ECE2023

Malignant Struma Ovarii: Report of Two Cases Diagnosed with Follicular Variant Papillary Thyroid Carcinoma

Gunduz Betul , Capkinoğlu Turk Sema , Kayhan Yusuf , Kılıc Kan Elif , Atmaca Aysegul , Colak Ramis

Introduction: Malignant struma ovari is a rare ovarian mature teratoma. The diagnosis can be done histopathologically. There are no specific diagnostic findings in terms of imaging, clinical and laboratory. We present two cases of malignant struma ovarii in papillary follicular variant subtypes in this report.Case report: Case 1; The patient was a 44 year old female, she had complaints of pelvic pain and a palpable lower abdominal mass. Pelvic MRI examin...

ea0090ep620 | Endocrine-related Cancer | ECE2023

Clinical Case: Missed Diagnosis of Poorly Differentiated Thyroid Cancer

Jokubauskaitę Sandra , Šimonienę Diana

Introduction: Poorly differentiated thyroid cancer (PDTC) is a rare subtype of thyroid carcinomas, that diagnosis is difficult and often missed in daily routine. It is believed that most of them arise in well-differentiated thyroid carcinoma, although a subset of these lesions apparently also arise de novo.Case report: In 2007, a 55-year-old man had a total thyroidectomy and received radioactive iodine treatment post-surgery due to well-differentiated pa...

ea0090ep621 | Endocrine-related Cancer | ECE2023

Systemic manifestations of medullary thyroid cancer

Matijaca Ana

78-year old previously healthy man was reffered to Outpatient endocrinology clinic due to painful spine and shoulders. His lumbar and thoracic X-ray showed decreased lumbar and thoracic vertebrae (L1, L2 and Th 5) and densitometry indicated slightly decreased bone density with T score -1,0 in left femoral neck and L1 vertebra. Since patient mentioned recent unintentionally 10 kg weight loss he was processed to further work-up and additional blood tests were done. Secondary ost...

ea0090ep622 | Endocrine-related Cancer | ECE2023

Primary multiple carcinomas: Papillary thyroid carcinoma and primary neuroendocrine liver carcinoma

Tigishvili Lali , Mchedlishvili Maya , Mchedlishvili Giorgi

Liver neuroendocrine carcinoma is a relatively rare disease. There is lack of description due to prognostic information of the disease. Liver serves as an visceral organ, taking part in several endocrine functions, according to an investigations has produced specific proteins and activate thyroid hormones, glucocorticoids. This article describes clinical case of 54 years man with clinical diagnosis of Grave’s disease. Liver examination showed normal liver hormones, radiol...

ea0090ep623 | Endocrine-related Cancer | ECE2023

Head circumferences measured during developmental monitoring visits before diagnosis of pediatric craniopharyngioma

Beckhaus Julia , Boekhoff Svenja , Krieger Leonie , Peng Junxiang , Friedrich Carsten , Muller Hermann

Craniopharyngiomas (CP) are congenital, benign, embryonic malformations which arise from ectoblastic remnants of Rathke’s pouch and are located in the (supra-)sellar region. Many patients show a reduced growth rate and an increased BMI early before the diagnosis of CP. However, it is unknown whether patients with CP present with increased head circumference before diagnosis. A cohort of 90 patients was screened for medical records of their developmental monitoring visits....

ea0090ep624 | Endocrine-related Cancer | ECE2023

Factors associated with dysglycemia and its post-surgical resolution in patients with Pheochromocytomas and Paragangliomas

Zhao Lin , Liu Yecheng , Zhou Xianliang

Background: Pheochromocytomas and paragangliomas (PPGLs) are a group of rare neuroendocrine tumors. Dysglycemia has been observed in patients with PPGLs in some small case series. However, few large studies, and none in China, have described the outcomes of dysglycemia after resection, and the factors associated with the development and resolution of dysglycemia in patients with PPGLs.Methods: We retrospectively analyzed the clinical data of consecutive ...

ea0090ep625 | Endocrine-related Cancer | ECE2023

Insulinoma: 4 case reports

Salem Maram Ben , Chiboub Marwa , Ben Hilel Wafa , Kandara Hajer , Kammoun Ines

Background: Insulinoma is a rare variety of endocrine neoplasm and is usually benign, solitary, and small in size. It is responsible of endogenous insulin secretion resulting in development of symptoms of hypoglycemia.Case presentation: We report 4 cases of insulinoma that were diagnosed and managed in the year 2022. Three women and one man aged respectively 76, 68, 60 and 42 years-old. All patients presented a long history of various adrenergic symptoms...

ea0090ep626 | Endocrine-related Cancer | ECE2023

Large bilateral adrenal masses: interest of plasma LDH measurement to detect adrenal lymphoma

Tauveron-Jalenques Urbain , Ravinet Aurelie , Guieze Romain , Brusseau Valentin , Tournilhac Olivier , Olivier Bay Jacques , Tauveron Igor

Large adrenal masses are strongly suggestive of malignancy. Nevertheless, bilateral adrenal masses are less common (around 20% of incidental adrenal lesions). Metastases and lymphoma are more frequent (especially when aging), and not so easy to differentiate on CT or MRI. Simple biological markers, such as plasma LDH or beta2microglobulin, could help.Case report: A 69-year-old patient was admitted for abdominal pain with progressive lethargy. Abdominal C...

ea0090ep627 | Endocrine-related Cancer | ECE2023

A case of synchronous association of stomach neuroendocrine tumor and pernicious anemia

Sabbagh Ghada , Elfekih Hamza , Aycha Ghachem , Saad Ghada , Houd Kenza , Taieb Ach , Ben Abdelkarim Asma , Hasni Yosra , Chadli Chaieb Molka

Introduction: Biermer’s disease is a chronic inflammatory disease due to antibodies targeting parietal cells and intrinsic factor compromising vitamin B12 absorption leading to pernicious anemia, and gastric acid secretion leading to achlorhydria. Neuroendocrine tumors are rare neoplasms that have been reported during the evolution of chronic gastritis. We here describe a case of a type 1 gastric neuroendocrine tumor discovered alongside with Biermer’s disease.<p...

ea0090ep628 | Endocrine-related Cancer | ECE2023

Pancreas, An Unusual Metastatic Site In A Long-term Indolent Surviving Case, Under Somatostatin Analogues Therapy, Of Medullary Thyroid Carcinoma: A Case Report And Review Of Cases Documented In Literature

Raia Salvatore , Chiloiro Sabrina , Giampietro Antonella , Grazia Maratta Maria , Schinzari Giovanni , Attili Fabia , Gabriella Brizi Maria , Rufini Vittoria , De Marinis Laura , Pontecorvi Alfredo , Rindi Guido , Bianchi Antonio

Medullary thyroid carcinoma (MTC) accounts for 1%–2% of thyroid cancers and has a variable clinical course. MTCs present with locoregional metastasis in 50% of patients and distant metastasis in 10% to 15% at the time of initial diagnosis. The lungs, liver, and bone are common metastatic sites, and distant metastasis is known to be a poor prognostic factor for long-term oncologic outcomes. We present the long course case, under somatostatin analogues (SSA) therapy, of a 7...

ea0090ep629 | Endocrine-related Cancer | ECE2023

A retrospective study investigating the potential relationship between obesity and thyroid cancer

Flood John , Mohamed Sara

Thyroid cancer is the most common endocrine malignancy, and accounts for between 5 and 10% of thyroid nodules biopsied in endocrine services. As per the Global Cancer Observatory, the incidence of thyroid cancer in Bahrain is 2.12 cases per 100 000 people, which is less than the neighbouring countries of Saudi Arabia and Kuwait. The purpose of the study is to investigate the relationship between thyroid cancer and obesity in Bahrain, where 28.9% of males and 38.2% of females a...

ea0090ep630 | Endocrine-related Cancer | ECE2023

Angiosarcoma of the thyroid: a case report

Azagouagh Hajar , Meryem Karimi , Ouirar Hasna , El Mazouni Zaineb , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamedelhassan

Introduction: Angiosarcomas are aggressive malignant tumors but very rare especially when they are located in the thyroid, characterized histologically by their vascular differentiation and their polymorphic appearance.Observation: We report the case of a 68-years-old female patient, from a mountainous region who has a history of cholecystectomy in 2018, she underwent a total thyroidectomy for a compressive goiter, the postoperative period was marked by ...

ea0090ep631 | Endocrine-related Cancer | ECE2023

The role of 131I whole body scan in post-operative assessment of patients with thyroid microcarcinoma

Suligowska Agnieszka , Walczyk Agnieszka , Gasior-Perczak Danuta , Palyga Iwona , Kuchareczko Artur , Kowalska Aldona

Introdutcion: In recent years, thyroid microcarcinoma (TMC) predominates in the context of diagnosis and treatment of thyroid cancer. TMC has an excellent prognosis, its management is changed in the last few years, reducing surgical procedure and role of radioiodine ablation (RAI). Therefore, the question is what tests have a diagnostic value in patients with thyroid microcarcinoma after thyroidectomyThe aim of this study was to evaluate the role of 131 ...

ea0090ep632 | Endocrine-related Cancer | ECE2023

The Thyroid extranodal marginal zone B-cell lymphoma of MALT: about 2 cases

M Bellakhdher , S Jemli , M Ghammem , Omri M El , Abed Y El , A Meherzi , J Houas , Kermani W El , Euch K El , M Abdelkefi

Introduction: Primary thyroid non-Hodgkin’s lymphoma (PT-NHL), is a quite rare entity, accounting for 1.3–1.5% of thyroid neoplasm, and 0.5% of lymphoma. The extranodal marginal zone B-cell lymphoma of MALT, occurs in 23% of PTL. The aim of our work is to evaluate the clinicopathological features and treatment outcomes of patients with MALT primary thyroid lymphoma. We report two cases of MALT PTL taken care of in our department.Observation 1: ...

ea0090ep633 | Endocrine-related Cancer | ECE2023

Carcinological factors associated with adrenal metastases in bronchopulmonary cancer: a comparative study

Mouhaymen Missaoui Abdel , Hamza Fatma , Soomauroo Siddiqa , Noomen Hiba , Belabed Wafa , Abid Mohamed

Objective: To study the carcinological factors associated with adrenal metastases (AMT) in bronchopulmonary cancer (PBC).Patients and Methods Case–control study analysing oncological data of 40 patients with PBC monitored by 18DFG PET/CT at the Nuclear Medicine Centre of Sfax, Tunisia. We compare the characteristics of 2 subgroups:G1 (n=17): patients with PBC and META (cases)G2 (n=23): ...

ea0090ep634 | Endocrine-related Cancer | ECE2023

Vascular damage after craniopharyngioma – a literature review

Beckhaus Julia , Boekhoff Svenja , Bison Brigitte , Friedrich Carsten , Muller Hermann

Craniopharyngiomas are rare, embryonic, malformational tumors of the (supra-)sellar region. Due to tumor and/or treatment-related hypothalamic lesions, patients develop morbid obesity. As a major vascular risk factor, obesity leads to reduced 20-year overall survival and a 3- to 19-fold higher cardiovascular mortality after craniopharyngioma compared to the general population. This review studies craniopharyngioma-specific risk factors for vascular damages. Three databases (Pu...

ea0090ep635 | Endocrine-related Cancer | ECE2023

Multiple endocrine neoplasia type 1: a case report

Dokmetaş Hatice Sebile , Zeynep Ağaoğlu Hikmet , Şahin Onur , Dokmetaş Meric , Eren Esma , Akkoyun Ayşenur , Kaan Turk Oğuz

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare, heritable syndrome characterized by a hyperparathyroidism, pituitary adenoma and pancreatic islet cells.Case: A 56-year-old male patient had a single parathyroid excised for primary hyperparathyroidism 10 years ago. He was further investigated due to hypoglycemia and a mass was found in the head of the pancreas on MRI. It was reported as neuroendocrine tumor and no recurrence was found i...

ea0090ep636 | Endocrine-related Cancer | ECE2023

MiNEN of the proximal colon – a strange case

Lazar Diana-Georgiana , Raluca Petria Andreea , Elena Oros Sabina , Dumitrascu Anda , Buduluca Larisa , Ionut Constantin Teodor , Grigore Iulia , Grigorie Daniel , Brezean Iulian , Dumitru Aldoescu Sorin , Degeratu Daniela

Introduction: Ectopic ACTH syndromes account for 5–10% of Cushing syndrome, with intrathoracic and gastrointestinal–pancreatic neuroendocrine tumors being the most common causes, followed by small cell lung cancer, adrenal paraganglioma and medullary thyroid carcinoma.Case report: A 50-year-old male hypertensive and diabetic patient was transferred to our clinic for emergency endocrine care for hypokalemia. He had mild hypercortisolism and live...

ea0090ep637 | Endocrine-related Cancer | ECE2023

Neuroendocrine carcinoma of the vagina in a young patient – a rare entity

Duta Simona Gabriela , Dumitras Teodor , Sorina Martin Carmen , Cima Luminita , Nitipir Cornelia , Terzea Dana , Fica Simona

Primary vaginal malignancy is uncommon, accounting for about 2% of all gynecological tract cancers, with small-cell neuroendocrine carcinoma of the vagina being exceptionally rare and aggressive. They display similar histological and immunohistochemical features to small-cell carcinomas of different origin. Few cases are reported in the literature so far and therefore, there is no current treatment protocol consensus. We report the case of a 34-year-old nulliparous patient, wh...

ea0090ep638 | Endocrine-related Cancer | ECE2023

Multiple endocrine neoplasia: about 9 cases

Soomauroo Siddiqa , Mnif Fatma , Mouhaymen Missaoui Abdel , Ben Salah Dhouha , El Arbi Kawthar , Lajmi Yosra , Hadj Kacem Faten , Elleuch Mouna , Charfi Nadia , Mnif Mouna , Abdelhedi Fatma , Rekik Nabila , Abid Mohamed

Introduction: Multiple endocrine neoplasia (MEN) is a group of inherited syndromes of autosomal dominant transmission characterized by the development of endocrine tumors.Materials and methods: It is a retrospective study collecting data of 9 patients with MEN, during a 30-year period.Results: The mean age at diagnosis was 34.6 years with a clear female predominance. The majority of our patients were from Gabes (4 cases). Seven pat...

ea0090ep639 | Endocrine-related Cancer | ECE2023

Neuroendocrine tumors of the head and neck: our experience

Jihene Houas , Jawaher Kechiche , Monia Ghammam , Heyfa Belhadjmiled , Omri Malika El , Mouna Bellakhdher , Abed Yosra Hasni El , Abir Meherzi , Wassim Kermani , Mohamed Abdelkefi

Introduction: Neuroendocrine tumors of head and neck region are rare and heterogeneous. it can arise in all the different organs of this region, including the nasal cavity, paranasal sinuses, larynx, thyroid, can be divided into two broad groups: those with epithelial differentiation, and neurally derived tumours, including paragangliomas and olfactory neuroblastomas. Their morphological and clinical features mainly depend on the degree of differentiation and on the site of or...

ea0090ep640 | Endocrine-related Cancer | ECE2023

Parathyroid cancer and of primary hyperparathyroidism

Elleuch Mouna , Souhir Maalej , Ghamgui Wissal , Ben Salah Dhoha , Souleima Trigui , Charfi Nadia , Mnif Mouna , Mnif Fatma , Rekik Majdoub Nabila , Hamza Fatma , Guermazi Fadhel , Kacem Akid Faten Haj , Abid Mohamed

Parathyroid cancer is a rare cause of primary hyperparathyroidism (PPH). The objective of this work is to discuss clinical and therapeutic specificities of these tumors.Case n°151-year-old woman from a consanguineous marriage, with a family history of recurrent renal lithiasis, neoplasia, and a personal history of breast neoplasia and uterine fibroid, consulted for abdominal pain, vomiting and weight loss. The diagnosis of pri...

ea0090ep641 | Endocrine-related Cancer | ECE2023

Cervical paragangliomas: clinical presentation and Managment modalities

Jihene Houas , Jawaher Kechiche , Monia Ghammam , Sarra Lazid , Omri Malika El , Mouna Bellakhhder , Abed Yosra Hasni El , Abir Meherzi , Wassim Kermani , Mohamed Abdelkefi

Introduction: Paragangliomas are a diverse group of neuroendocrine tumors arising from chromaffin cells within paraganglionic tissues of the autonomic nervous system.The aim of this study is to review our experience in the management of these tumors.Methods: The medical records of 12 patients with 13 paraganliomas was performed in a a single academic hospital over a period of 32 years from 1990 to 2022.Result...

ea0090ep642 | Endocrine-related Cancer | ECE2023

Syndrome of inappropriate antidiuretic hormone secretion associated with olfactory neuroblastoma

Malika El Omri , Ben Njima Marwa , Haouas Jihen , Abir Meherzi , Monia Ghammmam , Bellakhdhar Mouna , Wassim Kermani , Mohamed Abdelkefi

Introduction: Olfactory neuroblastoma causing syndrome of inappropriate antidiuretic hormone (SIADH) as paraneoplastic syndrome is very rare. There have been only 10 cases with antidiuretic hormone (ADH) producing olfactory neuroblastoma in the literature. The syndrome is due to ectopic production of protein hormones, hormone precursors, or hormone-like substances by the tumor tissue. Here, we report the case of olfactory neuroblastoma associated with SIADH.<p class="abste...

ea0090ep643 | Endocrine-related Cancer | ECE2023

atypical revelation of anaplastic thyroid cancer

Sellami Moncef , Chaabouni Mohamed Amin , Kharrat Ons , Kacem Akid Faten Haj , Abid Mohamed , Charfeddine Ilhem

The aim of this study is to report a case of an unusual presentation of anaplastic thyroid carcinoma and describe its clinical, radiological and management particularities. Observation: We report the case of a 60 year-old female patient who presented with a two-week history of progressive aphagia, associated with hemoptysis. She also described recent shortness of breath, and a painless cervical mass evolving for 10 months, rapidly enlarging during the last four weeks. Her medi...

ea0090ep644 | Endocrine-related Cancer | ECE2023

Mixed papillary–medullary thyroid carcinoma and cystic adrenal mass

Limniati Christina , Papagianni Eleni , Smarda Magdalini , Kaza Maria , Tsentidis Charalampos

Introduction: Regardless of the fact that the incidence of thyroid cancer has increased significantly in recent years, the simultaneous occurrence of multiple tumors in one thyroid gland is still a rare phenomenon. These tumors have the morphology, either of a single mass with mixed histological features, or of a single lesion consisting of two distinct cell-populations, or of two different tumors between which normal thyroid tissue is interposed. Various theories have been pr...

ea0090ep645 | Endocrine-related Cancer | ECE2023

Tall cell variant of papillary carcinoma on ectopic thyroid tissue

Nasr Maali Ben , Sellem Dorra Ben , Ben Hamida Ons , Belayouni Rihen , Zaabar Lamia , Mhiri Aida

Introduction: Ectopic thyroid tissue is a rare developmental abnormality due to aberrant embryogenesis and/or migration of the thyroid gland. Although rare (<1%), papillary thyroid carcinoma is the most common malignant transformation.Aim: Report a case of Tall cell variant of papillary carcinoma occurring on ectopic thyroid tissue in the thyroglossal duct.Observation: A 56-year-old male patient consulted for a cervical mass ap...

ea0090ep646 | Endocrine-related Cancer | ECE2023

Multiple Neuroendocrine tumours and role of clinical screening versus genetic testing

Ilyas Waqas , Abdelrehman Fahmy , Adam Safwan

Neuroendocrine neoplasms (NENs) are rare but diverse group of malignancies that can arise from gastroenteropancreatic tract and lungs. NENs can be clinically symptomatic (functioning) or silent (non-functioning). We present a case found to have multiple NENs in the absence of known clinical syndrome and discuss role of genetic testing versus clinical screening. 54 Female, referred to endocrine team for investigation of hypoglycaemic symptoms and suspected insulinoma. Routine b...

ea0090ep647 | Endocrine-related Cancer | ECE2023

Recurrent insulinoma: Case report

Maram Ben salem , Chiboub Marwa , Besrour Chayma , Jemel Manel , Kandara Hajer , Kammoun Ines

Background: Insulinoma is a rare neuroendocrine tumor that causes inappropriate secretion of insulin resulting in hypoglycemia. The diagnosis of insulinoma may be difficult. Recurrence after surgery is rare and it usually concerns tumors with high histological grade.Case presentation: We report a case of a 52-year-old woman with recurrent episodes of symptomatic hypoglycemia. The laboratory investigations showed high insulin (20 IU/ml) and C-peptide leve...

ea0090ep648 | Endocrine-related Cancer | ECE2023

Insulinoma in elderly

Besrour Chayma , Chiboub Marwa , Salem Maram Ben , Adel Meriem , Jemel Manel , Kandara Hajer , Kammoun Ines

Introduction: The insulinoma is a rare neuroendocrine tumor derived from the beta islet cell of the pancreas. It is usually sporadic and benign in 90% of the cases. It occurs more often in women in their fifties.Observation: We report the case of 76-year-old women with a medical history of hypertension and dyslipidemia, who was transferred to our department from the emergency unit after a diagnosis of severe episode of hypoglycemia (glucose level at 0.2 ...

ea0090ep649 | Endocrine-related Cancer | ECE2023

Asymptomatic Pheochromocytoma in a patient with Adrenal Incidentaloma

Raja Aoife , Meehan Conor , Crowley Rachel , Pyeh Kyithar Ma

Background: While the classic presentation of pheochromocytoma includes a triad of episodic headaches (90%), diaphoresis (60–70%), and palpitations (70%), literature has suggested 10% to 17% of patients with pheochromocytoma are either asymptomatic or mildly symptomatic; thus, highlighting the importance of appropriate endocrine work up of adrenal incidentalomas.Case: We report a 37-year-old male with a long-standing history of nocturia and dysuria,...

ea0090ep650 | Endocrine-related Cancer | ECE2023

Hidden insulinoma overlapped with pregnancy – a challenge for the clinician

Cristian Ioana Madalina , Andreea Balint Bianca , Petrescu Catalina , Mazilu Adina

Introduction: Insulinomas are the most common cause of hypoglycemia due to endogenous hyperinsulinism. Almost all insulinomas are benign, and long-term recovery with complete disappearance of preoperative symptoms can be expected after complete resection.Case report: A 33-year-old woman, who developed gestational diabetes during her second pregnancy, which persisted post-partum, stopped insulin due to recurrent severe hypoglycemia, but which persisted ev...

ea0090ep651 | Endocrine-related Cancer | ECE2023

Acromegaly and papillary thyroid carcinoma: Incidental association or causal link?

Gorgi Khaoula , Echchad Lamya , Guissi Loubna , Rifai Kaoutar , Iraqi Hinde , Hassan Gharbi Mohamed El

Introduction: Acromegaly is an unusual endocrinopathy due to hypersecretion of growth hormone (GH) and concomitant rise of IGF-1. It is associated with premature of mortality caused by cardiovascular, respiratory and metabolic diseases, as well as increased risk of developing boh benign and malignant tumours. We report the case of a patient with acromegaly associated with papillary thyroid microcarcinoma (PTC).CASEA 50-years -old m...

ea0090ep652 | Endocrine-related Cancer | ECE2023

Different phenotype of familial RET mutation in 2 patients: Medullary thyroid carcinoma and Adrenal Paraganglioma

Naglabeala Laura , Milicescu Alexandra , Galoiu Simona , Braha Elena , Muresan Andrei , Ioachim Dumitru , Ghemigian Mircea , Poiana Catalina

Introduction: RET proto-oncogene is situated on chromosome 10 and encodes a tyrosine kinase receptor. A germline mutation of RET leads to the appearance of MEN 2 syndrome or familial medullary thyroid carcinoma (MTC). One of the most common germline mutation occurs in codon 634. Pheochromocytoma penetrance for codon 634 mutation was demonstrated to increase with age up to 88% by age 77 years.Aim: To present two familial cases of RET mutation illustrating...

ea0090ep653 | Endocrine-related Cancer | ECE2023

The occurrence of adrenocorticotropic hormone-independant Cushing’s syndrome in a woman with the history of medullary thyroid carcinoma: a case report

Farid Hayfa , Saad Ghada , Ach Taieb , Fekih Hamza El , Ben Abdelkarim Asma , Hasni Yosra , Ameml Maaroufi , Kacem Maha , Molka Chadli , Ach Koussay

Background: Medullary thyroid carcinoma (MTC) is a rare neuroendocine tumor that that may be associated with paraneoplastic ACTH-dependent cushing syndrome. There are few case reports on the coexistence of medullary thyroid carcinoma and adrenal adenoma with ACTH-independent Cushing syndrome.Case presentation: We report the case of a 42-year-old woman, with no family history of endocrine malignancy or endocrine disorders. She underwent total thyroidectom...

ea0090ep654 | Endocrine-related Cancer | ECE2023

Weight loss in diabetics of 2 unbalanced revealing neoplasia

Ouhessaine Sofia , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: The incidence of cancer has increased in case of diabetes, as well as the metabolic abnormalities observed during diabetes could have a critical role on carcinogen, nevertheless one should not deny the implication of common factors to diabetes and cancer (obesity, smoking, advanced age, etc).Study objectives: Describe the biological and morphological screening methods for neoplasia in the event of weight loss concomitant with chronic glycem...

ea0090ep655 | Endocrine-related Cancer | ECE2023

Recurrent adrenocortical carcinoma: a case report

Salem Maram Ben , Jemel Manel , Salem Asma Ben , Chiboub Marwa , Kandara Hajer , Kammoun Ines

Background: Adrenocortical carcinoma is a rare malignancy with a poor prognosis. Local recurrence is affected by the pathologic features (tumor staging and mitotic index) and the complete surgical resection. Treatment of a recurrent adrenocortical carcinoma can be a real challenge.Case description: We report a case of 47-year-old man who was operated for an adrenal tumor with bone metastases. Left adrenalectomy and splenectomy were performed and histolog...

ea0090ep656 | Endocrine-related Cancer | ECE2023

Primary sinonasal neuroendocrine carcinoma invading the orbit

Sara Chtioui , Ismail Zahra , Rafi Sana , Tabib Ghizlane El Mghari , El Ansari Nawal

Introduction: Sinonasal neuroendocrine carcinoma SNECs are a rare group of neoplasms that account for only 5% of all sinonasal malignancies. SNECs are categorized by their differentiation grade into well-, moderately- and poorly differentiated.Case report: We describe a classical case of SNEC with secondary orbital involvement in a 34-year-old male patient presented of the occurrence of a right epistaxis. First of all, the patient is smoking. The beginni...

ea0090ep657 | Endocrine-related Cancer | ECE2023

Digestive endocrine tumors: better understanding for better treatment

Asfour Mustapha , Nfad Antonio , Errahali Yassine , Chakdoufi Sanae , Issouani Jade , Anas Guerboub Ahmed

Introduction: Digestive neuroendocrine tumors (DNETs) represent a heterogeneous group of tumors. This heterogeneity is manifested by the variable localization of these tumors but also by a great clinical and biological diversity. Thus, they occupy an increasingly important place in digestive oncology.NETs are very rare and represent about 1% of all digestive tumors, due to their slow evolution. The majority of them develop in the digestive tract (67.5%) ...

ea0090ep658 | Endocrine-related Cancer | ECE2023

Clear cell renal carcinoma synchronous with various endocrine pathologies

Petria Andreea Raluca , Lazar Diana-Georgiana , Elena Oros Sabina , Ioachim Dumitru , Ionut Constantin Teodor , Grigorie Daniel

Introduction: Clear cell renal carcinoma (ccRCC) is a subtype of renal cell carcinoma, the most frequent one (80%) and usually affecting only one kidney. It is twice as common in men than women between 50 to 70 years old. It can be associated with some genetic conditions that predispose patients to ccRCC, like Von Hipple-Lindau disease. Some clinical observations and molecular studies raised the hypothesis that RCC is a hormone−dependent tumor.Case...