Endocrine Abstracts

Introduction: Metabolic disorders caused by acromegaly are responsible for three times the morbidity of the general population

Study objectives: To analyze the different metabolic complications in acromegalic patients.

Materiel and methods: This is a retrospective study of 62 cases of acromegaly followed at the Department of Endocrinology and Metabolic Diseases CHU IBN ROCHD from January 2005 to December 2022. The data analysis was done with the Excel software in its 2021 version.

Results: The mean age was 54 years (17–88), Sex Ratio: F/H of: 2.6, the age of the disease at diagnosis averaged 10 years, the mean IFG1 level was 721.53 ng/ml. The average BMI level was 29 kg/m². The clinical examination found overweight in 15 patients or 24.19%, and obesity in 28 patients or 45.16%. The metabolic balance objectified carbohydrate metabolism disorders: prediabetes in 14 patients or 22.5% and diabetes in 27% patients or 43.5%. Dyslipidemia was objectified in 35 patients or 56.45% with a mean cholesterol level of 2 g/l, mean triglyceride of 1.7 g/l, mean HDL of 0.43 g/l and mean LDL level of 1.2 g/l. Hyperuricemia in 5 patients or 8% with an average uric acid level of 45 mg/l. All patients with carbohydrate metabolism disorders were put on hygiene-dietary measures, and in 74% on oral antidiabetics (ADO), and 21% on insulin therapy + ADO. Patients with dyslipidemia, were put in addition to hygiene-dietary measures adapted to statins in 65.2%. A marked improvement in the control balances has been achieved.

Conclusion: The systematic screening of metabolic complications in acromegalic patients and their early and adequate management is of major interest in order to prevent morbidity and mortality which results mainly that related to vascular accidents