Searchable abstracts of presentations at key conferences in endocrinology
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25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

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ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

Eposter Presentations

Pituitary and Neuroendocrinology

ea0090ep669 | Pituitary and Neuroendocrinology | ECE2023

Pituitary apoplexy triggered by COVID-19?

Nicolae Iolanda Brindusa , Gabriela Barbu Carmen

Introduction: Pituitary apoplexy is a rare and potentially life-threatening disorder defined by hemorrhage or infarction of the pituitary gland. Occasionally, it may be the first manifestation of an underlying adenoma.Case report: We present a case of a 70-year-old male, who was admitted in our clinic for an incidentally discovered pituitary macroadenoma accompanied by severe left hemicrania, otalgia and left eyelid ptosis.Medical ...

ea0090ep670 | Pituitary and Neuroendocrinology | ECE2023

Carney complex as a rare reason of acromegaly in adulthood

Perepelova Margarita , Przhiyalkovskaya Elena , Dzeranova Larisa , Pigarova Ekaterina , Kolodkina Anna

Carney complex is a rare hereditary syndrome with an autosomal dominant inheritance pattern that manifests itself with a set of specific symptoms. Case presentation. 32-year-old woman was admitted to the endocrinological hospital with an active stage of acromegaly. From the anamnesis it is known that at the age of 11, the height was 172 cm. The diagnosis of acromegaly was established at the age of 28 years: IGF-1 673.8 ng/ml (78–311), pituitary gland with para(d)-sellar s...

ea0090ep671 | Pituitary and Neuroendocrinology | ECE2023

Medical complications of craniopharyngioma management in a uk tertiary pituitary centre

Tzanninis Stamatios , Jamsheed Mohammed , Zolnourian Ardalan , Knysak Alicja , Hempenstall Jonathan , Mathad Nijaguna , Bujanova Jana , Al-Mrayat Ma'en

Background: Craniopharyngioma (CP) is a rare sellar or suprasellar epithelial tumour with a prevalence of approximately 2 per million and it occurs either in childhood between the ages of 5 and 14 years or in adulthood between the ages of 50 and 74 years. Histologically, CPs are divided into adamantinomatous, more prevalent in children, and papillary, more prevalent in adults. They are usually benign, but rare cases of malignant CPs have been reported. Clinical presentation is...

ea0090ep672 | Pituitary and Neuroendocrinology | ECE2023

Early Left Ventricular Diastolic Dysfunction in Females with Chronic Hyperprolactinemia: a Doppler Echocardiographic Study

Marra Alberto Maria , Arcopinto Michele , D'Assante Roberta , Valente Valeria , Simona Auriemma Renata , Crisci Giulia , Giardino Federica , Pirchio Rosa , Pivonello Rosario , Bossone Eduardo , Colao Annamaria , Cittadini Antonio

Despite the myocardial prolactin (PRL) binding activity and the known effect to enhance contractility in the isolated rat heart, little information is available concerning the cardiovascular consequences of hyperprolactinemia in humans. To elucidate the effects of chronic hyperprolactinemia on cardiac structure and function, twenty-four patients with isolated PRL-secreting adenoma and twenty-four controls underwent a complete mono- and two-dimensional Doppler echocardiography....

ea0090ep673 | Pituitary and Neuroendocrinology | ECE2023

Hyponatraemia post endoscopic pituitary surgery: A tertiary centre experience of a large cohort

Knysak Alicja , Mathad Nijaguna , Hempenstall Jonathan , Bujanova Jana , Al-Mrayat Ma'en

Post-pituitary surgery hyponatraemia (HN, sodium <135 mmol/l) is relatively common and may result in prolonged hospitalisation. Herein we report a retrospective analysis of our experience in a tertiary institute. We conducted a retrospective case note review of 318 patients (M 54%, F 46%, mean age 58 years) 65.7% non-functioning adenoma (NFA), 10% somatotropinoma, 5% prolactinoma, 11% corticotropinoma (half were clinically silent), 8% craniopharyngioma, an...

ea0090ep674 | Pituitary and Neuroendocrinology | ECE2023

Tolvaptan in the management of severe hyponatremia associated with acute intermittent porphyria

Gomez Carlos Garcia , Armengod Laura , Abad Ainhoa , Garcia Izquierdo Belen , Guzman Sanz Jorge , Rubio Ramos Miguel , Capristan Diaz Vanesa , Diez Fernandez Natalia , Palacios Nuria

Background: Acute intermittent porphyria (AIP) is an inherited autosomal dominant disorder characterized by hepatic deficiency of hydroxymethylbilane synthase (HMBS)/porphobilinogen deaminase (PBGD), the third enzyme of the heme synthesis pathway. Hyponatremia is one of the main presenting symptoms and it is thought to be related to an inadequate secretion of ADH (SIADH). Since AIP is an uncommon disease, there is little information about how AIP related hyponatremia responds ...

ea0090ep675 | Pituitary and Neuroendocrinology | ECE2023

Metabolic and surgical outcomes of adult patients with craniopharyngiomapatients undergoing extended transsphenoidal surgery (ETS) at a referral center

Pinar Gutierrez Ana , Dios Elena , Venegas-Moreno Eva , Remon Pablo , Oulad Ahmed Bothayna , Kaen Ariel , Cardenas Eugenio , Fajardo Elena , Cano Gonzales David , Soto-Moreno Alfonso

Objectives: To describe the metabolic and surgical outcomes of adult patients with craniopharyngioma undergoing extended transsphenoidal surgery (ETS). Secondary: to compare surgical outcomes with patients undergoing conventional transcranial surgery (CTS).Methods: Retrospective observational study. Adult patients with craniopharyngiomas undergoing ETS between 2015 and 2020 were included. Descriptive analysis was performed by obtaining median and quartil...

ea0090ep676 | Pituitary and Neuroendocrinology | ECE2023

Early postoperative growth hormone measurement as a predictor of surgical remission of acromegaly

Kraljevic Ivana , Kovač Diana , Solak Mirsala , Skoric Polovina Tanja , Zibar Tomšić Karin , Balasko Annemarie , Dusek Tina , Kastelan Darko

Purpose: To evaluate the value of early postoperative growth hormone (GH) as a predictor of surgical remission of acromegaly.Methods: We conducted a retrospective search through our database of patients who underwent transsphenoidal surgery for GH-secreting pituitary adenoma from 2011 to June 2022. Only patients who underwent the first pituitary surgery and had GH measurements on the fifth postoperative day were included. The surgical remission was defin...

ea0090ep677 | Pituitary and Neuroendocrinology | ECE2023

Prevalence and clinical characteristics of hyponatremia following pituitary surgery

Kosak Mikulas , Netuka David , Masopust Vaclav , Majovsky Martin , Jiskra Jan , Jezkova Jana

Introduction: Hyponatremia is one of the possible complications of pituitary surgery. Mild, asymptomatic hyponatremia can be managed with fluid restriction and oral supplementation, however more profound hyponatremia, especially when symptomatic, can be a reason for hospital readmission and often needs to be treated with saline infusion in ICU.Aims: To estimate prevalence of hyponatremia and provide clinical characteristics in the cohort of patients who ...

ea0090ep678 | Pituitary and Neuroendocrinology | ECE2023

Endocrine side effects of immune-checkpoint inhibitors in patients with malignant melanoma

Erdei Annamaria , Menes Enikő , Emri Gabriella

Immune-checkpoint inhibitors have become important elements of oncology therapy in recent years. These monoclonal antibodies block immune-checkpoints, unleashing T cells to fight cancer. However, immune-checkpoints also play an important role in the prevention of autoimmune processes and immune-checkpoint inhibitor therapy can also trigger autoimmune adverse effects, termed immune-related adverse events. Endocrinopathies are among the most common immune-related side effects.</...

ea0090ep679 | Pituitary and Neuroendocrinology | ECE2023

Epidemiologic and clinical characteristics of acromegaly in Russian hypothalamic and pituitary tumor registry (OGGO)

Lutsenko Alexander , Vikulova Olga , Belaya Zhanna , Przhiyalkovskaya Elena , Pigarova Ekaterina , Dzeranova Larisa , Rozhinskaya Liudmila , Melnichenko Galina , Mokrysheva Natalia

Background: Pituitary disease registries are major instruments of epidemiological and clinical data collection used worldwide.Objective: To assess the epidemiological and clinical characteristics of acromegaly in Russia according to Russian hypothalamic and pituitary tumor registryMaterial and methods: Database of the Russian hypothalamic and pituitary tumor registry, which includes data from 84 regions of the country, was used for...

ea0090ep680 | Pituitary and Neuroendocrinology | ECE2023

Clinical features and long-term follow-up of patients with Nelson syndrome: a case series presentation

Lutsenko Alexander , Trukhina Diana , Belaya Zhanna , Przhiyalkovskaya Elena , Dzeranova Larisa , Pigarova Ekaterina , Rozhinskaya Liudmila

Background: Nelson syndrome is a rare complication of Cushing disease (CD), which occurs either in patients with very aggressive CD or as a result of misdiagnosis. Clinical characterization of patients with Nelson syndrome could provide important insights in management of the disorder.Methods: We analyzed medical records of patients with CD between 2015 and 2021 to identify those who developed Nelson syndrome.Results: Nine patients...

ea0090ep681 | Pituitary and Neuroendocrinology | ECE2023

Prediction of the receptor phenotype of somatotrophic tumors and the effectiveness of the use of the first-generation somatostatin receptor ligands (fg-SRLs) in the long-term treatment of acromegaly

Pronin Evgeny , Antsiferov Mikhail , Alekseeva Tatiana , Lapshina Anastasia , Pronin Vyacheslav

The control of acromegaly with drug therapy (DT) by fg-SRLs is achieved only in 40–50% of cases, due to the heterogeneous composition of somatotrophic tumors. In order to optimize DT stratification of clinical and immunophenotypic biomarkers which make it possible to predict the long-term effectiveness of fg-SRLs at early stages is required. The aim of the work was to assess the informativeness of pharmacotherapeutic testing (% of decrease of IGF-1 level after 3 and 6 mon...

ea0090ep683 | Pituitary and Neuroendocrinology | ECE2023

Evaluation of the ACTH-CLU index for the differential diagnosis of ACTH-dependent Cushing’s syndrome

Izquierdo Belen Garcia , Rodriguez Delgado Laura , Araujo Castro Marta , Abad Lopez Ainhoa , Garcia Gomez Carlos , Rubio Ramos Miguel , Guzman Sanz Jorge , Diez Fernandez Natalia , Capristan Diaz Vanessa , Palacios Nuria

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...

ea0090ep684 | Pituitary and Neuroendocrinology | ECE2023

Neuroendocrine regulation of fluid and electrolyte metabolism in patients after transnasal adenomectomy: can oxytocin be a potential hormonal prognostic marker of hyponatremia?

Fargieva Khava , Katamadze Nino , Ivashenko Oksana , Azizyan Vilen , Grigoriev Andrey , Sergeev Arkadiy , Przhiyalkovskaya Elena , Pigarova Ekaterina , Dzeranova Larisa

Introduction: According to recent studies, fluid and electrolyte disturbances complicate the course of transnasal adenomectomy for pituitary adenomas in 13–30% of cases and are associated with a high risk of neurological complications and increased mortality. Neuropeptides discovered in recent decades (apelin, copeptin, oxytocin, brain natriuretic peptide) in many studies demonstrate their significant effect on the regulation of water-electrolyte metabolism, which makes t...

ea0090ep685 | Pituitary and Neuroendocrinology | ECE2023

Weight gain in adult patients with suprasellar craniopharyngioma with varying degrees of hypothalamic involvement before and after the surgery

Klochkova Irina , Astafieva Lyudmila , Kalinin Pavel , Kutin Maxim , Fomichev Dmitry , Shkarubo Alexsey , Sharipov Oleg , Sidneva Yulia , Konovalov Aleksandr

Suprasellar craniopharyngiomas (CF) are characterised by a high incidence of involvement of the third ventricle, which determines the risk of hypothalamic obesity (HO). There are no unified diagnostic criteria for HO and its effective treatment. The assessment of pre- and postoperative hypothalamic damage is necessary for the choice of surgical strategy and early therapeutic intervention.Objective: To estimate the incidence and extent of weight gain in a...

ea0090ep686 | Pituitary and Neuroendocrinology | ECE2023

Inferior petrosal sinus sampling and stimulation with CRH: 18 years of experience in a tertiary hospital

Montenegro Alejandra Maricel Rivas , Anez Roberto , Gonzalez Fernandez Laura , Munoz Diego , Garcia Piorno Alberto , Losada Gata Isabel , Gomez-Gordo Hernanz Monica , Collado Gonzalez Gloria , Carlos Percovich Juan , Gonzalez Albarran Olga , Garcia Centeno Rogelio

Background: Inferior petrosal sinus sampling (IPSS) is indicated in the diagnosis of adrenocor-ticotropic hormone (ACTH)-dependent Cushing’s syndrome (CS), especially when the results of the initial diagnostic tests are discordant.Objective: To describe the patients who underwent this invasive functional test in a tertiary hospital.Methods: This was an observational study of a retrospective cohort of patients with ACTH- depend...

ea0090ep687 | Pituitary and Neuroendocrinology | ECE2023

ADH-deficiency (central diabetes insipidus) registry in Russia: current results

Lutsenko Alexander , Pigarova Ekaterina , Dzeranova Larisa , Vikulova Olga , Belaya Zhanna , Rozhinskaya Liudmila , Mokrysheva Natalia , Consortium CDI The

Introduction: ADH-deficiency (central diabetes insipidus, ADH-D) is a rare disease, and data on worldwide and country-specific prevalence rates are scarce. ADH-D registries could provide valuable information on epidemiology, etiological distribution, treatment requirements and potentially serve as a guide for management decisions in clinical practice.Objectives: To assess the epidemiological data on ADH-D in Russian Registry for Central Diabetes Insipidu...

ea0090ep688 | Pituitary and Neuroendocrinology | ECE2023

The predictive value of IGF-1 in a cohort of children with growth hormone deficient and sufficient short stature

Maria Anton Ana , Cristina Georgescu Ioana , Tudorache Alina , Elena Teodora Gheorghe , Gabriela Barbu Carmen , Albu Alice

Introduction: Insulin-like growth factor 1 (IGF-1) is an established serum marker for both diagnosis of growth hormone (GH) deficiency and for monitoring treatment with Somatropin, whether it is recommended for the classic GH-insufficient short stature cases or for other GH-sufficient disorders.Aim: To evaluate whether serum level of IGF-1 at diagnosis has a predictive value for the response to somatropin treatment during the 2 years of treatment in chil...

ea0090ep689 | Pituitary and Neuroendocrinology | ECE2023

Clinical experience of single tertiary center in managing patients with paraganglioma

Kovacevic Valentina Elezovic , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Ilic Bojana , Opalic Milica , Radic Lena , P. Macut Djuro

Paragangliomas (PGLs) and pheochromocytomas (PCCs) are rare neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic neural ganglia, respectively. We retrospectively analyzed 82 patients (43 female and 38 males) predominantly with PGLs who were hospitalized between January 2002 and December 2022. Twenty one patients were lost to follow up. The median age at diagnosis was 47 years (11–75) and the mean tumor size was ...

ea0090ep690 | Pituitary and Neuroendocrinology | ECE2023

The role of peptide receptor radionuclide therapy in a case series of bronchial and gastroentero-pancreatic neuroendocrine tumors with secondary determinations

Stefania Stanca Oana , Stancu Cristina , Badiu Corin

Introduction: Neuroendocrine tumors (NET) represent a heterogeneous group of tumors with different locations, whose management is based on the pathology, immunohistochemical, genetic and molecular profile.Materials and method: We followed 8 patients with NET between 2014 and 2022 registered at the “C.I. Parhon” National Institute of Endocrinology, Bucharest, who benefited from peptide receptor radionuclide therapy (PRRT). Among them, 75% were m...

ea0090ep691 | Pituitary and Neuroendocrinology | ECE2023

A systematic review of pituitary apoplexy and Takotsubo cardiomyopathy

Mahdavi Javad , Valeh Touraj

Introduction: Pituitary apoplexy is defined as a clinical syndrome resulting from sudden hemorrhage or infarction of the pituitary gland, mostly within a pituitary micro/macroadenoma. One of the rare diseases that has been reported following pituitary apoplexy is Takotsubo cardiomyopathy (TC). TC, also known as stress cardiomyopathy, is a transient left ventricular dysfunction in the absence of coronary artery disease that is usually associated with psychological and physiolog...

ea0090ep692 | Pituitary and Neuroendocrinology | ECE2023

Macrohormones (“incidental hormones”) – a diagnostic challenge in endocrinology: macro-ACTH

Vanuga Peter , Urbankova Helena , Sagova Ivana , Kulich Michal , Huba Peter , Vanuga Anton

Background: If the laboratory results are not compatible with the patient’s clinical symptoms, the presence of possible test interference should be considered. Despite the excellent quality of immunoassays, it is currently estimated that they may be susceptible to several types of interference that may lead to patient misdiagnosis.Case report: In our case report we present a 71-year-old woman with confirmation of macro-adrenocorticotropic hormone (m...

ea0090ep693 | Pituitary and Neuroendocrinology | ECE2023

New point mutation in the KAL 2 gene

Garcia Reyes Rave , del Castillo Eduardo Torrecillas , deVera Gomez Pablo Rodriguez , Martinez Brocca Maria Asuncion , Martin Hernandez Tomas

Although we know the gene alterations associated with KAL 2, at present we still do not know certain mutations of the fibroblast factor receptor 1 gene (FGFR gene) that even show complete penetrance of the syndrome. Kallman syndrome is a genetic disease of embryonic development characterized by the association of hypogonadotropic hypogonadism due to GnRH hormone deficiency because of agenesis or hypoplasia of the olfactory sulci. Three subtypes have been described; the classic...

ea0090ep694 | Pituitary and Neuroendocrinology | ECE2023

Thyrotropin-secreting pituitary tumor: a rare entity

Torrecilla Pedro Jimenez , Gonzalez Lazaro Paloma , Moreno Tirado Antonio , Montero Benitez Maria Zhao , Lomas Meneses Amparo , Del Val Zaballos Florentino , Contreras Pascual Cristina

TSH-secreting pituitary adenomas are a rare cause of hyperthyroidism. The diagnosis should be considered in all hyperthyroid patients, especially those with a diffuse goiter and no extrathyroidal manifestations of Graves’ disease. Most TSH-secreting adenomas secrete only TSH. Most patients have the typical symptoms and signs ofhyperthyroidism (eg, palpitations, tremor, heat intolerance), but a few patients have mild or even no hyperthyroid symptoms. Other clinical feature...

ea0090ep695 | Pituitary and Neuroendocrinology | ECE2023

Anti PD1 induced hypophysitis: a different nosological entity?

Laamouri Rihab , Clothilde Wagner , Naculina Racolta

Introduction: The indications for anti-PD1 agents have expanded considerably in recent years, particularly for the treatment of melanoma, lung cancer and kidney cancer.Hypophysitis is a rare complication of anti-PD1 agents (< 1%) often with an atypical presentation, characterized by a later onset and a less symptomatic presentation.Case report: A 60-year-old woman was diagnosed with a clear cell renal carcinoma, treated with le...

ea0090ep696 | Pituitary and Neuroendocrinology | ECE2023

Clinical case of reverse hearing loss in a patient with acromegaly and pituitary macroadenoma

Perepelova Margarita , Dzeranova Larisa , Shutova Aleksandra , Lepeshkina Lyudmila , Pigarova Ekaterina , Azizyan Vilen , Akopyan Pavel , Przhiyalkovskaya Elena

Background: Acromegaly is an orphan neuroendocrine disease characterized by a variety of complications. Due to slow symptom progression acromegalic patients often are involved in growth hormone complications correction for a long time instead of search for main cause of these multiple disorders. A view on conductive hearing loss in acromegaly in literature is contradictory. The low incidence of hearing in acromegaly, compared with other complications, is presumably due to the ...

ea0090ep697 | Pituitary and Neuroendocrinology | ECE2023

Prolactinoma’s resistance: diagnostic and treatment perspectives via pharmacokinetic and metabolomic characteristics

Shutova Aleksandra , Dzeranova Larisa , Pigarova Ekaterina , Usoltseva Liliya , Fedorova Natalia , Ioutsi Vitalii

Introduction: Prolactinomas are the most common type of pituitary adenomas(40% of them), representing a significant cause of infertility and hypogonadism. About 20% of patients with prolactinomas don’t respond satisfactory(i.e. resistant) even to high dose dopamine agonist(DA) treatment(>3.5–4.5 mg/week). Worth noticing that there are no clear signs to anticipate this resistance but to stepwise increase the dose of DA. In addition, the etiology of resistance &#15...

ea0090ep698 | Pituitary and Neuroendocrinology | ECE2023

Are neurosteroids related to anxiety and quality of life in cases with acromegaly?

Burhan Sebnem , Hacıoğlu Yalcın , Polat Yeliz , Furkan Arslan Hilmi , Balcı Ekmekci Ozlem , Niyazoğlu Mutlu , Hatipoğlu Esra Şuheda

Background: Anxiety level is higher in the samples consisting of people diagnosed with pituitary adenoma, including patients with acromegaly, compared to the normal population. A higher level of anxiety indicates a lower Quality of Life (QoL) in acromegaly. This study aimed to evaluate and discuss the possible relationship between anxiety and NS in people with acromegaly.Method: This cross-sectional comparative study included an acromegaly group (AG, <em...

ea0090ep699 | Pituitary and Neuroendocrinology | ECE2023

Pathologic characteristics of somatotroph pituitary tumors – an observational single-center study

Tomasik Agnieszka , Stelmachowska-Banaś Maria , Maksymowicz Maria , Czajka-Oraniec Izabella , Dorota Raczkiewicz , Zgliczyński Wojciech

Background: The first-line treatment in acromegaly is transsphenoidal adenomectomy of GH-secreting pituitary tumor. Pathologic evaluation of postoperative tissue is an essential part of patient’s assessment.Aim: The aim of this study was to analyse pathologic characteristics of pituitary tumors in patients with acromegaly.Patients and methods: One hundred twenty patients with acromegaly after at least one pituitary surgery tre...

ea0090ep700 | Pituitary and Neuroendocrinology | ECE2023

Outcomes of Surgically treated Pituitary Adenomas in Malta – A Population-Based Study

Mangion Jessica , Giordano Imbroll Miriam , Vassallo Josanne , Gruppetta Mark

Aim: The sequelae of surgically treated pituitary adenomas (PAs) is an important area of study to help guide management. Our study aims to analyse all PAs, functional and non-functional, which were operated until the end of 2022 in a well-defined population and to identify radiological characteristics that can predict recurrence before operation.Methods: 206 PAs were evaluated along with their clinical, radiological, and histopathological characteristics...

ea0090ep701 | Pituitary and Neuroendocrinology | ECE2023

Surgical treatment of prolactinomas

Nasybullina Farida , Vagapova Gulnar , Pashaev Bakhtiyar , Ashimova Regina

It is known that treatment of prolactinomas with dopamine agonists is accompanied by relapses of the disease after discontinuation of the treatment in about 50% of cases and long-term or lifelong medication is required. The aim of the study was to evaluate the effectiveness of surgery in achieving remission or biochemical control of the disease. We prospectively enrolled 32 consecutive patients with prolactinomas who underwent transsphenoidal resection performed by the highly ...

ea0090ep702 | Pituitary and Neuroendocrinology | ECE2023

Pituitary apoplexy: clinical characteristics and management

Blanco Jessica Ares

Background and aims: Pituitary apoplexy (PA) is a rare clinical syndrome due to pituitary hemorrhage or infarction. It is an emergent and potential life-threatening complication of pituitary adenomas if not managed properly. It is usually characterized by the sudden onset of one or more of the following: severe headache, visual disturbance, nausea/vomiting, and or altered mental status. We aimed to present clinical and biochemical characteristics as well as management of patie...

ea0090ep703 | Pituitary and Neuroendocrinology | ECE2023

Silent pituitary macroadenomas – clinical behavior and prognosis

Manique Ines , Amaral Sara , Palha Ana , Cortez Luisa , Cerqueira Luis , Sagarribay Amets , Silva-Nunes Jose

Introduction: A third of pituitary adenomas are non-functioning. Classification depends on adenohypophyseal hormones expression and transcription factors.Aim: Characterize silent pituitary macroadenomas cases regarding their clinical data, treatment, histopathology and prognosis.Methods: We revised clinical process of patients followed in CHULC. Cases with non-access to clinical follow-up registries or exams were excluded.<p cl...

ea0090ep704 | Pituitary and Neuroendocrinology | ECE2023

Pituitary abscess masquerading as meningitis with partial anterior pituitary deficiency

Seshadri Shyam

A 34-year-old woman presented with a worsening headache 4 weeks post-partum following emergency caesarean section. She described the headache as the worst that she had experienced, and this was made worse by bending forwards and with associated photophobia. A CT head scan revealed pan sinusitis and a suggestion of a pituitary tumour while lab results showed mild hyponatremia along with low TSH and FT4. An initial working diagnosis of likely meningitis was made, and she commenc...

ea0090ep705 | Pituitary and Neuroendocrinology | ECE2023

Pituitary macroadenoma apoplexy following treatment with pembrolizumab

Lopes Stephanie Andrade , Sciotto-Canel Lucie , Momjian Shahan , Aissa Assma Ben , Brocco Elise , Becquart Ondine , Egervari Kristof , Merkler Doron , Jornayvaz Francois , Leboulleux Sophie , Mavromati Maria

A 70-year old man was referred to the endocrinology department for the evaluation of a pituitary macroadenoma which was diagnosed during work-up for a malignant melanoma. Pituitary MRI showed a 20×21×25 mm adenoma with supra-sellar extension and no compression of the optic chiasma. Hormonal work-up revealed central hypogonadism and slight hyperprolactinemia due to stalk compression, while pituitary function was otherwise normal. MRI follow-up was scheduled in six mon...

ea0090ep706 | Pituitary and Neuroendocrinology | ECE2023

Translation into Portuguese and cultural adaptation of the Literacy Independent Cognitive Assessment

Santos Lucas B. , Kellner Michael , Oliveira Walter , Faro Andre , Oliveira Carla R P , Batista Vanderlan O , Oliveira-Santos Alecia A , de Brito Iris de Vita Alves , Almeida Viviane , Villar-Gouy Keila R , Leal Angela , Amorim Rivia S , Melo Enaldo V , Santos Elenilde G , Salvatori Roberto , Aguiar-Oliveira Manuel H.

Population aging has become a universal worldwide phenomenon. Developing countries (such as Portuguese-speaking countries, with a high rate of illiteracy) will see the greatest increase in the absolute number of elderly people, and dementia disorders will pose enormous challenges to public health in these countries. Although the decline in GH secretion with age has been associated with deleterious conditions of aging, our understanding is the opposite, that the decline in GH s...

ea0090ep707 | Pituitary and Neuroendocrinology | ECE2023

Safety and efficacy of once weekly somapacitan versus once daily growth hormone among adults with growth hormone deficiency: A systematic review and meta-analysis

Co Faith Abigail , Baliclic Micah Fiel , Sese Kevin , Pagcatipunan Jr. Rodolfo S

Background: Adult growth hormone deficiency (AGHD) has been increasingly observed among patients with traumatic brain injury, stroke, and central nervous system infection, aside from the subgroup of patients with pituitary tumors. When left untreated, these patients have a significantly increased risk to develop cardiovascular morbidity and mortality and impaired psychosocial function. Existing treatment guidelines on AGHD have recommended the use of growth hormone (GH) replac...

ea0090ep708 | Pituitary and Neuroendocrinology | ECE2023

Giant pituitary adenomas: Clinical and paraclinical features, management, and outcome

Chayma Bel Hadj Sliman , Oueslati Ibtissem , Terzi Ameni , Ayari Sabrina , Yazidi Meriem , Chihaoui Melika

Introduction: Giant pituitary adenomas are defined as tumors with largest diameter ≥40 mm. They are characterized by high invasiveness causing compression of adjacent structures and hormonal dysfunction. The aim of this study was to determine the clinical and paraclinical features, management, and outcome of giant pituitary adenomas.Methods: This was a single-center retrospective study including patients with giant pituitary adenoma. Clinical and p...

ea0090ep709 | Pituitary and Neuroendocrinology | ECE2023

Long-term Clinical Outcomes in Acromegaly

Mamoojee Yaasir , Pervez Muhammad Hassaan , James Andy , Shery Neville

Background: Acromegaly is a rare condition characterised primarily by tumourous production of excess Growth Hormone (GH) from a pituitary adenoma. Clinical management aims at normalising serum IGF1 levels within sex and age-adjusted reference parameters. Treatment options include pituitary surgery, medical therapy with somatostatin analogue (SSA), cabergoline, pegvisomant or radiotherapy. A combination of treatment modalities is common for the majority of patients.<p class...

ea0090ep710 | Pituitary and Neuroendocrinology | ECE2023

Serum prolactin levels and correlation to clinical diagnosis: a study of 259 patients with hyperprolactinaemia

Yin Win Lei , Evans Carol , Tennant Sarah , Lansdown Andrew

Introduction: Hyperprolactinaemia is a common finding in endocrine practice and can be due to a number of causes. The degree of elevation of prolactin levels may sometimes be helpful in distinguishing between underlying aetiology.Aim: To determine if hyperprolactinaemia is correlated with clinical diagnosis in a cohort of patients in the endocrine service at a tertiary centre.Methods: A biochemistry database held at University Hosp...

ea0090ep711 | Pituitary and Neuroendocrinology | ECE2023

Can early post-operative hypocortisolaemia predict remission after transsphenoidal surgery in Cushing’s disease

Khan Irfan , James Andy , Rashid Razan Ali , Nicholson Claire , Mamoojee Yaasir

Background: Cushing’s disease (CD) is rare, and standard treatment is trans-sphenoidal surgery (TSS). We previously reported a remission rate of 56% in patients undergoing TSS for CD from a microadenoma/normal pituitary on MR in our unit. Early post-operative hypocortisolaemia performs well at predicting durable remission early on. Post-operative day 1 cortisol of <55 nmol/l has a 100% sensitivity and <138 nmol/l 95% sensitivity at predicting remission. Since Octo...

ea0090ep712 | Pituitary and Neuroendocrinology | ECE2023

Thyroid fine needle aspiration for the diagnosis of Langerhans Cell Histiocytosis of the suprasellar region

Sciotto-Canel Lucie , Lopes Stephanie Andrade , Caironi Verdiana , Saiji Essia , Vargas Maria-Isabelle , Jornayvaz Francois R , Momjian Shahan , Stalder Gregoire , Leboulleux Sophie , Mavromati Maria

A 25-year old woman with Hashimoto thyroiditis was referred to the endocrinology department for investigation of a 40 kilogram weight gain, polyuria, polydipsia and secondary amenorrhea. Hormonal work-up showed diabetes insipidus, central hypogonadism, secondary adrenal insufficiency, central hypothyroidism and slight hyperprolactinemia. Pituitary magnetic resonance imaging (MRI) revealed a 15 mm hypothalamic tumor expanding to the infundibulum, associated with pituitary stalk...

ea0090ep713 | Pituitary and Neuroendocrinology | ECE2023

Kisspeptin Kindred: Case Report and Literature Review

Sanpawithayakul Kanokporn , Howard Sasha , Korbonits Marta

Context: Normosmic idiopathic hypogonadotropic hypogonadism (nIHH) is a rare endocrine disease in which patients have isolated gonadotropin releasing hormone (GnRH) deficiency in the context of otherwise normal structure and function of anterior pituitary and hypothalamus with normal olfactory ability.Objective: To explore the underlying pathogenic defect in patients with delayed puberty.Patients: We investigated genetic defects in...

ea0090ep714 | Pituitary and Neuroendocrinology | ECE2023

A patient with two forms of PA – pituitary adenoma and primary aldosteronism

Aung Htet Htet , Zeeshan Amna , Macfarlane James , Allison Kieren , Kaplan Felicity , Bashari Waiel , Gurnell Mark

Background: Clinically relevant pituitary adenomas (Pit PA) affect approximately 1:1200 of the general population, and may manifest with hormone hypersecretion, hypopituitarism and compression of the visual pathways. Primary aldosteronism (Adr PA) is now recognised to account for 5–14% of all cases of hypertension and is associated with excess morbidity when compared with primary hypertension. Here, we report a patient who was noted to have a history suggestive of Adr PA ...

ea0090ep715 | Pituitary and Neuroendocrinology | ECE2023

Predictive factors of biochemical remission after transsphenoidal surgery in acromegaly

Faten Cherchir , Mekni Sabrine , Essayeh Sawsen , Abidi Sahar , Mchirgui Nadia , Nacef Ibtissem Ben , Rojbi Imen , Khiari Karima

Introduction: Excessive production of growth hormone (GH) in acromegaly is most commonly caused by a somatotroph pituitary adenoma. The therapeutic arsenal is based on selective transsphenoidal adenomectomy (STA) as a first-line treatment. The aim of our study was to determine predictive factors of postoperative biochemical remission in acromegalic patients.Methods: We conducted a retrospective study including 18 acromegalic patients followed-up in the e...

ea0090ep716 | Pituitary and Neuroendocrinology | ECE2023

Coexistence of acromegaly and Xanthomatous Hypophysitis

Uzman Rukiye Dilara Tekin , Burhan Sebnem , Dogukan Fatih Mert , Kocak Burak , Hatipoglu Esra Suheda , Niyazoglu Mutlu

Introduction: Hypophysitis is a rare pituitary inflammation due to primary and secondary causes. Xanthomatous hypophysitis is the rarest subtype and described with lipid-laden cystic areas, transparent cytoplasmic and lipid-laden histiocytes and foamy (xanthomatous) histiocytes. Although the etiology of xanthomatous hypophysitis is not clearly known, it has been suggested to develop as a result of autoimmune cause or inflammatory process of infiltration of cyst components from...

ea0090ep717 | Pituitary and Neuroendocrinology | ECE2023

Bilateral petrosal sinus sampling – a 15-year experience from a tertiary hospital

Ferreira Helena Urbano , Goncalves Juliana , Belo Sandra , Alves Goncalo , Silva Maria Luis , Carvalho Davide , Freitas Paula

Introduction: In patients with ACTH-dependent Cushing Syndrome, differentiating between pituitary and ectopic sources can be challenging. Noninvasive testing can be performed, but bilateral inferior petrosal sinus sampling (BIPSS) remains the gold standard. In the last years however, novel imaging modalities, namely 3T-MRI with 3-dimensional spoiled gradient-echo sequence and 68Ga-tagged CRH combined with positron emission tomography, have been proposed as alternatives.<p ...

ea0090ep718 | Pituitary and Neuroendocrinology | ECE2023

Radiological characteristics of pituitary adenomas in men

Salah Dhoha Ben , Souleima Trigui , Akid Faten Haj Kacem , Hamdi Frikha , Charfi Nadia , Mnif Mouna , Mejdoub Nabila , Mnif Fatma , Elleuch Mouna , Abid Mohamed

Background and aims: Pituitary adenomas (PA) are small, generally benign tumors found in the pituitary gland. PA in men are rare However, they are characterized by the frequency of invasive and aggressive tumours, which makes their management difficult. The aim of this study is to clarify radiological characteristics of pituitary adenomas in men. Materials and methods: Retrospective descriptive study of 80 adult men with PA, hospitalized in the endocrinology department from 19...

ea0090ep719 | Pituitary and Neuroendocrinology | ECE2023

Polyuria after steroid replacement in a patient with adrenal insufficiency – not always vasopressin deficiency

Narula Kavita , Nyunt Sandhi , Sharma Aditi , Lazarus Kate , Falinska Agnieszka , Russell-Jones David , Meeran Karim

A 54-year-old man with a recurrent non-functioning pituitary gonadotroph adenoma previously treated with transphenoidal surgery (TSS) in 2015, presented to Charing Cross hospital for repeat transsphenoidal surgery in May 2022. Since his initial surgery, he remained on Levothyroxine 50 μg once daily only. There was no evidence of adrenal insufficiency (0900 h cortisol 333 nmol/l at day 6 following initial TSS). In February 2022, his electrolytes, FSH, LH, testosterone, pro...

ea0090ep720 | Pituitary and Neuroendocrinology | ECE2023

Increased mortality in COVID-19 patients with admission hyponatremia is associated with sustained hyponatremia, and volemia-inappropriate therapy

Guerra Mario Pazos , Sanchez Jorge Gabriel Ruiz , Candel Xavier Perez , Nevado Celia Lopez , Olmeda Fernando Hernandez , Monteros Patricia Espinosa De Los , Hernandez Martin Cuesta , Calle Alfonso , Martin Javier Sanchez , Runkle Isabel

Introduction: Admission hyponatremia, frequently detected in patients hospitalized for COVID-19, has been associated with increased mortality. However, although SIADH-induced euvolemic hyponatremia is the single most-common cause of hyponatremia in community-acquired pneumonia, repercussions of admission-hyponatremia volemic classification on COVID-19 hospitalizations have yet to be described. We sought to identify factors contributing to mortality and hospital length-of-stay ...

ea0090ep721 | Pituitary and Neuroendocrinology | ECE2023

An international, simulated-use study assessing nurses’ preferences between two lanreotide syringes (Somatuline Autogel vs Pharmathen) for treatment of neuroendocrine tumours (NETs) and/or acromegaly: PRESTO 3

Ferone Diego , Martin Wendy , Williams Jessica , Houchard Aude , Pommie Christelle , Ribeiro-Oliveira Antonio , Grossman Ashley B

Introduction/Background: Patients with NETs and acromegaly are commonly treated with somatostatin analogues (SSAs), such as octreotide and lanreotide depot formulations. The Pharmathen syringe is now available in several European countries and the USA for lanreotide depot injection. When using SSAs, confidence in and ease of use with syringes is important for decision-making in long-term therapy.Aims: PRESTO 3 compared nurses’ preference for the Som...

ea0090ep722 | Pituitary and Neuroendocrinology | ECE2023

Experience with cabergoline in the treatment of an active gonadotropinoma

Klochkova Irina , Astafieva Lyudmila , Shkarubo Alexsey , Sidneva Yulia , Kalinin Pavel , Urakov Sergey , Badmaeva Inna , Sergeeva Natalia , Zorilova Irina

Gonadotropinomas secreting biologically active hormones, most commonly follicle-stimulating hormone (FSH), are a very rare pathology. The clinical manifestations depend on the gender and age of the patient. Men may observe enlarged testicles and erectile dysfunction. Reports on the results of the drug treatment are sporadic.Objective: To describe a rare clinical case of an active giant FSH-secreting pituitary tumour in a 62-year-old man with the developm...

ea0090ep723 | Pituitary and Neuroendocrinology | ECE2023

Cure rates after different therapy lines among patients with growth hormone (GH)-secreting pituitary adenomas

Moure Maria Dolores , Ortiz Elizabeth Salinas , Del Diego Maria Munoz , Estella Elena Gonzalez , Arauco Claudia Sanchez , Sandi Javier Santamaria

Introduction: Even Though resection via transsphenoidal surgery is the optimal primary treatment for growth hormone (GH) secreting pituitary adenomas, medical therapy must also be considered when biochemical control after surgery is not achieved. The aim of our study was to describe the cure rates of acromegaly patients after different lines of therapy.Methods: A retrospective study (1971–2022) of 89 patients diagnosed with acromegaly was conducted....

ea0090ep724 | Pituitary and Neuroendocrinology | ECE2023

Case report of a patient with partial antidiuretic hormone deficiency (central diabetes insipidus)

Katamadze Nino , Shutova Aleksandra , Fargieva Khava , Pigarova Ekaterina , Dzeranova Larisa

Introduction: Diabetes insipidus (DI) is a rare condition characterized by excretion of large amounts of dilute urine and increased thirst due to deficiency or renal resistance of antidiuretic hormone (ADH). DI is often difficult to diagnose reliably and accurately, especially in patients with partial DI.Aim: The aim of our case report is to present the patient with partial diabetes insipidus and to report the results of water deprivation and hypertonic ...

ea0090ep725 | Pituitary and Neuroendocrinology | ECE2023

Coexistence of PRL-secreting adenoma and germ cell tumor in 14-year-old adolescent

Kalinin Alexey , Strebkova Natalia , Chugunov Igor , Kolesnikova Galina , Bezlepkina Olga , Zheludkova Olga , Peterkova Valentina

Coexistence of different types of brain tumors is a very rare condition. We present a clinical case of PRL-secreting adenoma and germ cell tumor coexistence in 14-year-old adolescent. The patient was admitted to our Center with complaints of headache with nausea episodes, left-sided ptosis. Visual acuity was: visus OD=1.0; visus OS=0.6 Cyl -0.5 ax 70=1.0. Neuroimaging revealed supra-para(D,S) sellar mass 39×32×21 mm. Laboratory data revealed hypothyroidism, hypocorti...

ea0090ep726 | Pituitary and Neuroendocrinology | ECE2023

Joint disease in patients with acromegaly

Perepelova Margarita , Przhiyalkovskaya Elena , Tarbaeva Natalya , Dzeranova Larisa , Pigarova Ekaterina , Kovalevich Liliya

Background: Acromegaly is a neuroendocrine disease that occurs with slowly progressive symptoms, which leads to delayed diagnosis and the development of complications. Arthropathy is one of such complications, which is accompanied by severe pain and significantly worsens the quality of life. The main attention of researchers is devoted to the pathology of the hip, knee and hand joints. At the same time, the study of the shoulder, acromioclavicular, costovertebral joints in acr...

ea0090ep727 | Pituitary and Neuroendocrinology | ECE2023

Prolactin-secreting pituitary adenoma: Clinical, radiological features and predictors of response to dopamine agonists

Romanisio Martina , Ferrero Alice , Daffara Tommaso , Catenazzi Sara , Pitino Rosa , Cavigiolo Beatrice , Zavattaro Marco , Marzullo Paolo , Caputo Marina , Prodam Flavia , Aimaretti Gianluca

Aim: Prolactinomas are the most frequent pituitary adenomas. Clear predictors of response to dopamine agonists (DA) are still discussed. The purpose of the study was to evaluate the clinical, radiological and hormonal characteristics of PRL-secreting pituitary adenomas, and to evaluate morphological changes over time and predictors of response to DA.Patients and Methods: Patients affected by PRL-secreting adenoma undergoing DA therapy in follow-up in a t...

ea0090ep729 | Pituitary and Neuroendocrinology | ECE2023

Features of pituitary macroadenomas with one size less than 10 mm

Krivosheeva Yulya , Ilovayskaya Irena

There are clinical recommendations to conduct a hormonal investigation in all cases of pituitary tumors > 6 mm in size that seems to be uncertain.The objective: To reveal features of pituitary macroadenomas with at least one size less than 10 mmThe materials and methods: We have analyzed medical records of 380 newly diagnosed patients with pituitary macroadenomas before any treatment: 162 non-functioning adenomas (NFAs), 74 pro...

ea0090ep730 | Pituitary and Neuroendocrinology | ECE2023

Precision medicine in acromegaly: results of the ACROFAST study

Puig-Domingo Manel , Marques-Pamies Montserrat , Gil Joan , Valassi Elena , Gimenez-Palop Olga , Hernandez Marta , Taibo Rocio Villar , Biagetti Betina , Villarroya Gemma Xifra , Simo-Servat Andreu , Zavala Roxana , Simon Inmaculada , Araujo-Castro Marta , Centeno Rogelio Garcia , Calatayud Maria , Miguel Federico Vazquez San , Vilarrasa N , Vert Isabel Salinas , Mora Mireia , Hanzu Felicia Alexandra , Novoa Maria Paz De Miguel , Pavon Isabel , Blanco Concepcion , Alvarez-Escola Cristina , Sampedro-Nunez Miguel Antonio , Jorda Mireia , Bernabeu Ignacio , Webb Susan , Marazuela Monica

Medical treatment of acromegaly is currently performed through a trial-error manner using somatostatin receptor ligands (SRLs) as first-line drugs. Average SRLs response is seen in 50% of cases; subsequent drugs are indicated following clinical judgement. Some biomarkers either before or after surgical failure have been reported to predict SRLs response, including intensity in T2 weighted MRI, short acute octreotide test (sAOT), and different molecules such as SST2 and E-cadhe...

ea0090ep731 | Pituitary and Neuroendocrinology | ECE2023

Management of necrolytic migratory erythema with lanreotide a patient diagnosed with pancreatic glucagonoma: A rare case report

Ulusoydan Ege , Erturk Banu , Gedikoglu Mustafa Gokhan , Yalcın Suayip , Şendur Suleyman Nahit

Introduction: Glucagonomas are rare neuroendocrine tumours (NET). Glucagonoma syndrome is often misdiagnosed as other skin lesions by clinicians due to typical clinical sign of necrolytic migratory erythema (NME). In this article, we report a metastatic glucagonoma case diagnosed at adult age with distinct features of the disease.Observations: We present a case of a 28-year-old female patient. The initial rash appeared in early 2019 and was mostly on low...

ea0090ep732 | Pituitary and Neuroendocrinology | ECE2023

Pituitary metastasis in neuroendocrine neoplasms, lesson learned from cases reports

Ganawa Shawg , Ilyas Waqas , Irshad Shadman , Hamad Adeel , Pathmanaban Omar , Milanovic Dusan , Colaco Rovel , Blackhall Fiona , Valle Juan , Ho Jan Hoong , Adam Safwaan

Introduction: Pituitary metastases (PM) are an uncommon manifestation of Neuroendocrine neoplasms (NENs) and are rarely reported. We report two cases of PM with different clinical lessons.Case 1: A 37-year-old female underwent surgical resection for a high grade poorly differentiated neuroendocrine carcinoma of the cervix (Ki67 90%). Serial follow-up surveillance assessments revealed disease progression (local, liver, lung, and bone) for which she underw...

ea0090ep733 | Pituitary and Neuroendocrinology | ECE2023

Endogenous hyperinsulinemic hypoglycemia: A retrospective analysis of 10 cases

Belabed Wafa , Mnif Fatma , Missaoui Abdel Mouhaymen , Elleuch Mouna , Charfi Nadia , Mejdoub Nabila , Mnif Mouna , Abid Mohamed

Background and aim: Non-diabetic hypoglycemia is a rare entity that regroups several pathologies. Its exact diagnosis is mostly challenging. Endogenous hyperinsulinism is a curable cause that should be thoroughly screened. The objective of our study was to analyze the ethipathological aspects of hypoglycemia by endogenous hyperinsulinism.Patients and methods: We conducted a retrospective study at the Endocrinology department of Hedi Chaker University Hos...

ea0090ep734 | Pituitary and Neuroendocrinology | ECE2023

The Strongest Clinical Tool is the Patient’s Voice

McBride Margaret

Introduction: As a Cushing syndrome (CS), patient myself and healthcare researcher I recognise that the patient’s voice is the strongest weapon in a clinician’s toolbox. Conducting a Doctor of Philosophy (PhD), study on a condition you have been diagnosed with was a journey of discoveries. My CS took almost 7 years to diagnose having been referred to a myriad of physicians prior to my definitive diagnosis. This was the driving force behind my desire to find out if ot...

ea0090ep735 | Pituitary and Neuroendocrinology | ECE2023

Predictive clinical factors of stature gain in congenital growth hormone deficiency treated patients

Haj Kacem Akid Faten , Belabed Wafa , Missaoui Abdel Mouhaymen , Safi Wajdi , Elleuch Mouna , Mnif Fatma , Salah Dhoha Ben , Mejdoub Nabila , Mnif Mouna , Abid Mohamed

Background and aim: The management of Congenital Growth hormone deficiency (CGHD) is based on hormonal substitution with recombinant GH. The stature prognosis may be affected by several clinical, genetic, and therapeutic factors. This study aims to assess the predictive clinical factors of stature gain in CGHD-treated patients.Patients and Methods: We conducted a retrospective study (1991–2019) at the Endocrinology department of Hedi Chaker Universi...

ea0090ep736 | Pituitary and Neuroendocrinology | ECE2023

Morphological pituitary abnormalities in patients with congenital Growth Hormone deficiency

Akid Faten Haj Kacem , Missaoui Abdel Mouhaymen , Belabed Wafa , Safi Wajdi , Charfi Nadia , Mnif Fatma , Salah Dhoha Ben , Mejdoub Nabila , Mnif Mouna , Abid Mohamed

Background and aim: Disorders of the development of the pituitary gland could result in some forms of Congenital Growth hormone deficiency (CGHD). This study aims to assess the morphological abnormalities of the pituitary gland in patients with CGHD.Patients and Methods: We conducted a retrospective study (1991–2019) at the Endocrinology department of Hedi Chaker University Hospital, Sfax, Tunisia. We involved 87 patients diagnosed with CGHD, whose ...

ea0090ep737 | Pituitary and Neuroendocrinology | ECE2023

Predicting the risk of developing cerebrospinal fluid fistula in patients with prolactinoma

Cuconu Diana , Marin Alexandra , Badiu Corin

Introduction: Prolactin secreting pituitary adenoma represents the most common functioning pituitary neoplasm with a clinical picture that includes amenorrhea, galactorrhea and infertility. Tumor size may vary from microadenomas amendable to medical therapy with dopamine agonists to macroadenomas with difficult management. Complications are usually related to tumor size and most frequently include hypogonadism alone or associated with other pituitary deficiencies, visual field...

ea0090ep738 | Pituitary and Neuroendocrinology | ECE2023

Pituitary macroadenoma, incidental finding after soccer match

Valles Cristina Serrano , Sanchez Higinio Ortega , Pascual Cristina Contreras , Rosas Karol Almendra Alvarado

Introduction: Thyrotropin-secreting pituitary tumors (TSH-omas) are a rare disorder and an infrequent cause of hyperthyroidism. The prevalence in the general population being 1 to 2 cases per million. However, recents studies have demonstrated an increase of TSH-omas over time. The increased number of cases principally results from the ultrasensitive TSH immunometric assays and from improved general practioner endocrinologist awaress. There is an inappropriate secretion of TSH...

ea0090ep739 | Pituitary and Neuroendocrinology | ECE2023

Homocysteine levels in acromegaly patients: comparison of active disease with remission

Tanrikulu Seher , Demirbas Zeynep Ece , Elci Mehmet Emre

Objective: Acromegaly is associated with increased cardiovascular mortality. Hyperhomocysteinemia has been associated with cardiovascular disease, lower-extremity peripheral arterial disease and heart failure. Data on the prevalence of hyperhomocysteinemia and peripheral arterial disease in patients with acromegaly is still limited. The aim of this study was to compare serum homocysteine levels between acromegaly patients with active disease and remission, and to evaluate pres...

ea0090ep740 | Pituitary and Neuroendocrinology | ECE2023

Pituicytoma – case report of an extremely rare and little-studied primary tumour of the adult neurohypophysis

Taqi Muhammad , Akbar Shahzad , Malik Shah Rukh , Mongolu Shiva

The pituicytomas are extremely rare and little-studied primary tumours of the adult neurohypophysis. These are low-grade (World Health Organization [WHO] grade 1), indolent gliomas which present as a sellar mass, which is usually mistaken for a pituitary adenoma, and has no known hormonal secretory function. A 63 years old retired paediatrician was referred to the neurology clinic with the history of constant severe headache ongoing for a few weeks. It involved the whole of th...

ea0090ep741 | Pituitary and Neuroendocrinology | ECE2023

Vitamin D status and cardiovascular risk in a cohort of acromegalic patients

Toma Iustin-Daniel , Trifanescu Raluca , Mohora Maria-Alexandra , Baciu Ionela , Baculescu Nicoleta , Burcea Iulia Florentina , Capatina Cristina , Dusceac Roxana , Andreea Găloiu Simona , Niculescu Dan Alexandru , Nitu Ileana , Radian Serban , Poiana Catalina

Background: Vitamin D deficiency is the most common nutritional deficiency, estimated to affect almost one billion people worldwide. Multiple factors influence 25(OH)D levels: nutrition, sunlight exposure, outdoor physical activity, skin color. Patients with active acromegaly (AA) have lower 25(OH)D levels compared with healthy population and are at a higher risk to develop vitamin D deficiency. Also, some studies have suggested a possible protective role of vitamin D on the c...

ea0090ep742 | Pituitary and Neuroendocrinology | ECE2023

Hyponatremia apparently due to carbamazepine as the initial presentation of panhypopituitarism in a patient with a non-functioning pituitary tumour

Vladan Andreea , Iancu Cristina , Radian Serban , Poiana Catalina

Introduction: Hyponatremia, defined as a serum sodium concentration below 135 mEq/l, has a heterogeneous etiology, the main endocrine causes includind the syndrome of inappropiate antidiuresis (SIAD), adrenal insufficiency and severe hypothyroidism.Materials and methods: Clinical, hormonal and imaging evaluationAim: To present a case of hyponatremia leading to the diagnosis of a large pituitary tumorCase pres...

ea0090ep743 | Pituitary and Neuroendocrinology | ECE2023

Survey on caregivers’ experiences and perspectives on children’s daily growth hormone treatment

Korhonen Pia , Ruotsalainen Jarno , Polkki Mari , Prami Tuire , Siven Mia , Turunen Juha

Background and objective: Human recombinant growth hormone (hrGH/GH) is an injectable medication used commonly for growth hormone deficiency (GHD) and other health conditions that reduce growth and adult height. Daily GH injections can burden families and result in poor adherence. This study was conducted to investigate caregivers’ experiences, attitudes and preferences regarding pediatric GH treatment. At the time of data collection, the long-acting GH products were not ...

ea0090ep744 | Pituitary and Neuroendocrinology | ECE2023

Growth hormone treatment tends to promote hepatic VLDL1-triglyceride export in humans

Baumgartner Clemens , Metz Matthaeus , Schnait Franziska , Tosin Anna , Beghini Marianna , Fellinger Paul , Beiglboeck Hannes , Pfleger Lorenz , Vila Greisa , Luger Anton , Kautzky-Willer Alexandra , Stangl Herbert , Krssak Martin , Furnsinn Clemens , Scherer Thomas , Krebs Michael , Wolf Peter

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a systemic, metabolic condition associated with increased morbidity and mortality. Defined by an increase in hepatic lipid content (HCL), NAFLD develops in consequence of lipid oversupply and/or a diminished disposal of hepatic lipids. The latter may include an impaired export of triglycerides (TG) via the secretion of very-low density lipoprotein1 (VLDL1) particles, an important mechanism of the liver to protect itsel...

ea0090ep745 | Pituitary and Neuroendocrinology | ECE2023

Patient-centric design of the lonapegsomatropin auto-injector for pediatric growth hormone deficiency

Lau Michael , Fabricius Paul Erik , Jensen Josephine , Madsen Nils Berg , Egesborg Henrik

Background: Lonapegsomatropin (SKYTROFA™; TransCon hGH), an FDA and EMA approved once-weekly prodrug of somatropin for pediatric growth hormone deficiency (pGHD), uses TransCon® technology to transiently link an inert carrier to a parent drug to achieve sustained release. Daily growth hormone injection, standard treatment for pGHD for decades, may be associated with challenges including needle anxiety and low adherence. The lonapegsomatropin Auto-Injector, winner of ...

ea0090ep746 | Pituitary and Neuroendocrinology | ECE2023

Tumor mimicking ampullary carcinoma in a patient with acromegaly

Bnina Molka Ben , Ghada Sabbagh , Elfekih Hamza , Saad Ghada , Fatma Barkallah , Hasni Yosra , Chaieb Molka Chadli

Introduction: Acromegaly is the set of clinical manifestations induced by chronic exposure to an endogenous excess of growth hormone (GH). Most often, acromegaly is related to GH production by a pituitary adenoma. It may be associated with neuroendocrine tumors of the pancreas as part of multiple endocrine neoplasia type 1 (MEN1). Herein, we described a tumor mimicking a carcinoma of the Ampulla of Vater in a patient with acromegaly.Observation: A 54-yea...

ea0090ep747 | Pituitary and Neuroendocrinology | ECE2023

Immune landscape of peripheral blood mononuclear cells in patients with Cushing’s syndrome and mild autonomous cortisol secretion

Bauerle Ariane , Nowotny Hanna F , Doll Natalie , Zopp Stephanie , Nowak Elisabeth , Vogel Frederick , Gottschlich Adrian , Seiter Thomas Marchant , Reisch Nicole , Rothenfuszer Simon , Matthias Kroiss , Braun Leah , Reincke Martin

Background: Endogenous Cushing’s syndrome (CS) is associated with increased susceptibility to infections and mortality. Previously reported effects of hypercortisolism on immune function include a reduced CD4+/CD8+ ratio with a shift towards IL4+T helper cells (Th2), suppressed NK-cell cytotoxic activity as well as a low-grade inflammatory profile.Aim: This cross-sectional single center study aims to compare immune phenotype in patients with overt C...

ea0090ep748 | Pituitary and Neuroendocrinology | ECE2023

Clival prolactinoma: A case report

Adel Meriem , Chiboub Marwa , Maram Ben Salem , Besrour Chayma , Kandara Hajer , Jemel Manel , Kammoun Ines

Introduction: Ectopic pituitary adenomas (EPAs) are extremely rare intracranial tumors. Since 1909, few cases has been reported in the literature. We report a case of clivus prolactinoma.Case report: A 52-year-old women with a history of infertility, presented one year ago at the emergency with headaches and a sudden decreased visual acuity. The pituitary MRI revealed an arachnoidocele, pituitary adenoma of the left cavernous lodge measuring 20×18&#...

ea0090ep749 | Pituitary and Neuroendocrinology | ECE2023

A case of Turner syndrome associated with growth hormone deficiency

Serban Cristina , Baculescu Nicoleta , Poiana Catalina

Background: Turner syndrome (TS) is an important cause of short stature, however, there are a few reported cases of concomitant occurrence of TS and growth hormone deficiency (GHD).Case report: We report a 23-year-old female with concominat TS and GHD, also presenting partial FSH/LH deficiency and primary myxedema. The patient had iniatially been evaluated at the age of 15 for short stature and primary amenorrhea when she was diagnosed with Turner syndro...

ea0090ep750 | Pituitary and Neuroendocrinology | ECE2023

Sheehan syndrome revealed by acute adrenal insufficiency 3 months after the delivery

Laamouri Rihab , Smagala Agnes , Niculina Racolta

Introduction: Sheehan syndrome (SS) is a hemorrhagic necrosis of the pituitary gland responsible of anterior pituitary insufficiency. It occurs in a context of cerebral hypo flow due to a rapid blood pressure drop and/or acute hemorrhagia. We report a case of SS revealed by acute corticotropic insufficiency.Case report: A sunday morning 34 years-old woman consulted the emergency department for of a fatigue and diarrhea. She reported a 7 kg weight-loss in...

ea0090ep751 | Pituitary and Neuroendocrinology | ECE2023

Every post op hyponatremia is not a SIADH; missed case of hypopituitarism after TBI

Azad Fatima , Meeking Darryl

Introduction: The incidence of hospitalised and fatal traumatic brain injury(TBI) is 235/100 000 with an average mortality rate of 15/100 000. A meta-analysis from 19 studies showed a prevalence of hypopituitarism after TBI of 27.5%.Case report: We report case of 72-year-old man, who suffered traumatic brain injury in October 2021, sustaining multiple skull fractures, with traumatic subarachnoid haemorrhage and subsequent pneumocephalus. He underwent bur...

ea0090ep752 | Pituitary and Neuroendocrinology | ECE2023

Response to quinagolide of a pituitary prolactin macroadenoma

Amel Rahal

Introduction: The treatment of prolactin adenomas is medical based on the use of dopaminergic agonists but the presence of an underlying valvulopathy makes the treatment by cabergoline delicate.Clinical case: We report the case of a 60 year old female patient, operated on for aortic valve disease, with moderate mitral leakage. On the occasion of a decrease in visual acuity; a prolactin macro adenoma is diagnosed In agreement with the cardiologist; we opt...

ea0090ep753 | Pituitary and Neuroendocrinology | ECE2023

Double functional pituitary adenomas causing acromegaly and subclinical Cushing disease

Salhi Salma , Oueslati Ibtissem , Ziouche Sarra , Hammami Fatma , Yazidi Meriem , Chihaoui Melika

Introduction: Double Pituitary adenomas with growth hormone (GH) and adrenocorticotropic hormone (ACTH) secretion are very rare. They are responsible for acromegaly with hypercortisolism. Subclinical corticotropic adenomas are exceptional. Herein, we report the case of a patient with double functional pituitary adenomas causing acromegaly and subclinical Cushing’s disease.Observation: A 45-year-old woman was referred to our department for suspected ...

ea0090ep754 | Pituitary and Neuroendocrinology | ECE2023

Isolated hypopituitarism as the first manifestation of neurosarcoidosis

Ghram Lina , Oueslati Ibtissem , Yazidi Meriem , Salhi Salma , Boussema Fatma , Chihaoui Melika

Introduction: Sarcoidosis may affect the central and peripheral nervous systems in 5–16% of patients. In most cases, such involvement occurs within a multi-systemic disease. Neurological involvement is rare but a potentially life-threatening form of sarcoidosis. The endocrine manifestations of neurosarcoidosis include hypothalamic dysfunction, diabetes insipidus, hypopituitarism, and amenorrhea–galactorrhea syndrome. Herein, we report the case of a patient with hypop...

ea0090ep755 | Pituitary and Neuroendocrinology | ECE2023

Cushing’s disease with empty sella turcica: A problematic situation

Mohamed Ali Boutheina , Mohamed Moctar , Cheikh Mariem , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamedelhassan

Introduction: Cushing’s disease is characterized by an endogenous hypercortisolism related to a pituitary adenoma, its association with an empty sella turcica is exceptionally rare.Case report: A 55 year old diabetic patient with hypertension was admitted for investigation of Cushing’s syndrome. Clinical examination found facial and truncal obesity with facial erythrosis, capillary fragility with multiple ecchymoses, proximal amyotrophy of the ...

ea0090ep756 | Pituitary and Neuroendocrinology | ECE2023

Intrasellar ectopic salivary gland rests related with Rathke’s cleft cyst

Burhan Sebnem , Uzman Dilara , Erkan Buruc , Kocak Burak , Doğukan Fatih Mert , Niyazoğlu Mutlu , Hatipoğlu Esra Şuheda

Introductıon: Rathke’s cleft cysts (RCCs) are benign lesions originating from the epithelial remnants of Rathke’s pouch with a peak incidence at 30–50 years of age. It is detected at a rate of 13–33% in several autopsy series. RCC is usually asymptomatic and diagnosed incidentally. In symptomatic cases, common symptoms are headache, visual disturbance, and symptoms related to hypopituitarism.Case: A 28-year-old male patient prese...

ea0090ep757 | Pituitary and Neuroendocrinology | ECE2023

A dwarfism revealing a Pituitary stalk interruption syndrome (PSIS) at the age of 36 years

Dounia Talbi , Amira Ikram , Azriouil Manal , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamedelhassan

Introduction: Pituitary stalk interruption syndrome (PSIS) is a distinct developmental defect characterized by a thin or absent pituitary stalk, hypoplasia of the adenohypophysis, and ectopic location of the neurohypophysis.Case report: A 36 years old male patient, full term born by vaginal delivery, with birth asphyxia. Birth weight was 2800 g, length was 51 cm, and no other postnatal events were noticed. Psychomotor milestones were achieved normally. h...

ea0090ep758 | Pituitary and Neuroendocrinology | ECE2023

Pituitary apoplexy in cabergoline-resistant macroprolactinoma

Meletli Ozlem Kanburoglu , Birinci Cigdem , Bilginer M. Cuneyt , Coskun Hulya , Nuhoglu Irfan , Ucuncu Ozge , Kocak Mustafa

Introduction: Pituitary apoplexy is a life-threatening clinical syndrome that develops as a result of bleeding or infarction in a pituitary adenoma. Here, we aimed to present a case of cabergoline-resistant macroprolactinoma who developed pituitary apoplexy.Case Report: A 40-year-old male patient presented to neurology 2 years ago with severe headache. Brain magnetic resonance imaging (MRI) revealed a 15.5×18×21 mm macroadenoma in the pituitary...

ea0090ep759 | Pituitary and Neuroendocrinology | ECE2023

Endocrinopathy behind the facemask – follow up

Nyunt Sandhi , Sharma Aditi , Narula Kavita , Mitchell Catherine , Mendoza Nigel , Ling Yong Yong , Hatfield Emma , Meeran Karim , Martin Niamh

A 44-year-old gentleman presented to the Emergency Department with a 2-week history of fever and rigors. Past medical history was unremarkable other than an earlier diagnosis of hypertension. He was noted to have new onset atrial fibrillation with rapid ventricular response; a diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) was made on echocardiography. In addition, a vegetation was identified on the mitral valve. Treatment for infective endocarditis (Streptoco...

ea0090ep760 | Pituitary and Neuroendocrinology | ECE2023

Recurrence of ACTH dependent Cushing’s syndrome after pregnancy: Clinical case

Kozhemzharova Malika , Bazarova Anna

Introduction: Pituitary ACTH-dependent Cushing’s syndrome (CS) is a condition characterized by an overproduction of cortisol due to pituitary adenoma which infers high morbidity and mortality. Transsphenoidal surgery (TSS) is the first-line therapy of an ACTH-secreting pituitary adenoma. But, even after surgical resection of the adenoma, up to 50% of cases may develop a recurrence of the disease.Case presentation: A woman, 32 year-old, developed rec...

ea0090ep761 | Pituitary and Neuroendocrinology | ECE2023

Delayed onset of pasireotide-induced hyperglycemia: Report of two cases

Stormann Sylvere , Schilbach Katharina , Amereller Felix , Schweizer Junia Ribeiro de Oliveira Longo , Schopohl Jochen

Introduction: Pasireotide is a potent somatostatin analogue (SSA) and used in therapy-refractory acromegaly, commonly after failure of treatment with first-generation SSA. However, it may induce severe hyperglycemia, which usually occurs rapidly after initiation of therapy and in general gradually improves over time. We here present two cases of young male patients who developed severe pasireotide-induced hyperglycemia after several years of treatment.Ca...

ea0090ep762 | Pituitary and Neuroendocrinology | ECE2023

Challenges in the management of prolactinomas: A case of partial resistance to high-dose cabergoline in a young male with an invasive giant prolactinoma

Cheţan Larisa-Nicoleta , Vladan Andreea , Hortopan Dan , Gobej Ionut , Radian Serban , Poiana Catalina

Background: Giant prolactinomas are rare pituitary tumours larger than >40 mm in diameter, representing 2–3% of prolactin secreting tumours. Management is challenging especially in male patients, due to resistance to dopamine agonists (DA).Methods: Clinical, hormonal and imaging evaluation and follow-upAim: To describe a case of partially resistant giant prolactinoma in a young male patientCase repor...

ea0090ep763 | Pituitary and Neuroendocrinology | ECE2023

A rare case of Cushing syndrome ectopic-ACTH

Bammou Sanaa , Hassan Neima , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Malignant tumors, nevertheless, have been associated with extremely high circulating ACTH and cortisol levels, and short duration of symptoms of Cushing syndrome (CS) besides atypical clinical phenotype, when compared with pituitary-dependent Cushing. Identification of the source of ACTH can be challenging, as sometimes the primary lesion is not identified even after prolonged and repeated follow-upCase report: A 33-year-old woman with a hi...

ea0090ep764 | Pituitary and Neuroendocrinology | ECE2023

A very rare case of familial glucagonoma with renin co-secretion and hypokalemia in MEN1 multiple neoplasia

Poalelungi Ramona , Daniel Mihai , Badiu Corin

Introduction: A glucagonoma is a rare neuroendocrine tumor that originates almost exclusively in the pancreas and probably accounts for 1% of all neuroendocrine tumors. MEN11 is characterized by the development of primary hyperparathyroidism (PHPT), pancreatic neuroendocrine tumors and pituitary adenomas.Methods: We present the case of a 39-year-old female, with history of type 2 diabetes mellitus and hypokalemia2 who presented to t...

ea0090ep765 | Pituitary and Neuroendocrinology | ECE2023

‘Needless needles’: Can GH injections be prevented by treatment of deep vitamin D deficiency?

Davidse Kirsten , van Eck Judith , van den Akker Erica , van der Lely Aart-Jan , de Graaff Laura

Introduction: Growth hormone (GH) is not only important for growth during childhood. Also, for (young) adults, growth hormone is important for bone mass, muscle strength and metabolism. GH deficiency (GHD) is a condition that can cause a broad range of adult health issues, if left untreated. Therefore on one hand, it is important to confirm and treat GHD after transfer to adult care. On the other hand, the personal and financial burden of unnecessary growth hormone in...

ea0090ep766 | Pituitary and Neuroendocrinology | ECE2023

Gaps in the long term post-treatment follow-up of pituitary tumors

Imran Paras , Ahsan Tasnim , Dilawar Heer

Objective: To study the spectrum of Pituitary tumours, their presentation, treatment and compliance with follow-up.Methods: A mixed retrospective and prospective study was conducted at the Medicell Institute of Diabetes, Endocrinology and Metabolism (MIDEM) and Jinnah Postgraduate Medical Centre (JPMC) Karachi, Pakistan. All cases of pituitary tumours, were prospectively followed. Data regarding age, gender, duration of disease, symptoms, mode of treatme...

ea0090ep767 | Pituitary and Neuroendocrinology | ECE2023

Autosomal dominant familial neurohypophyseal diabetes insipidus in three generations

Bammou Sanaa , Ouakrim Hind , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Familial neurohypophysial diabetes insipidus (FNDI), an autosomal dominant disorder, comes in many forms that are differentiated by the inheritance pattern and the underlying genetic lesion. The disease is caused by mutations in the vasopressin-neurophysin 2-copeptin protein (AVP-NPII), in wolframin (WFS1) or in proprotein convertase subtilisin/kexin type 1 (PCSK1) genes.Materials and methods: In this study, we report a case of familial neu...

ea0090ep768 | Pituitary and Neuroendocrinology | ECE2023

Pituitary spindle cell oncocytoma presented as pituitary apoplexy, case study

Khadidja Bessaid , Mezoued Mouna , Azzouz Malha

Introduction: Spindle cell oncocytoma (SCO) of the pituitary gland is a rare thyroid transcription factor 1 (TTF-1)-positive pituitary neoplasm.Observation: We report the case of a 42-year-old man, with a personal history of type 2 diabetes, consulting for intense headaches and vomiting. The visual field shows an amputation of the left temporal hemifield and the MRI shows a pituitary adenoma with suprasellar development, initially measuring 22×28&#2...

ea0090ep769 | Pituitary and Neuroendocrinology | ECE2023

MRI assessment of typical pituitary gland size and shape: Age and gender associated changes

Shankar Anand , Bharti B B , Sinha Ajay Kumar , Kumar Subhash

Background: For a thorough evaluation of the pituitary gland, it is important to understand its typical structure, including the physiological differences in size and form across age groups in both males and females.Objectives: To use magnetic resonance images to examine the size, shape, and average normal volume of the normal pituitary gland at various age groups in both genders (MRI).Material and methods: 200 individuals who unde...

ea0090ep770 | Pituitary and Neuroendocrinology | ECE2023

Re-evaluation of MRI in the follow-up of acromegaly – a path towards long-term remission?

Atai Shahriar , Andersen Martin Knudtzon , Bollerslev Jens , Dahlberg Daniel , Wiedmann Markus , Ringstad Geir Andre , Heck Ansgar

Introduction: Remission by complete surgical tumour removal is not achieved in all patients with acromegaly and a subset of patients remain on long-term pharmacological treatment. Repeated surgery or targeted radiation therapy can be considered in patients with residual or recurrent tumour. Identification of residual or recurrent tumour available for surgical treatment can be challenging, and underreporting may lead to a loss in treatment opportunity. The aim of the present st...

ea0090ep771 | Pituitary and Neuroendocrinology | ECE2023

A rare case of macro-ACTH in patient with adrenal incidentaloma

Przybycień Piotr , Gasior-Perczak Danuta , Słuszniak Anna , Placha Wojciech , Kowalska Aldona

Introduction: Adrenocorticotropic hormone (ACTH) is a tropic hormone produced by the anterior pituitary that stimulates the adrenal glands to release cortisol. The ACTH measurement is often used to diagnose the pituitary and/or adrenal disorders, mainly Cushing’s disease, Cushing’s syndrome, Addison’s disease and hypopituitarism. Therefore, the assessment of plasma ACTH concentration is a crucial step in the differential diagnosis of hypothalamic–pituitary&...

ea0090ep772 | Pituitary and Neuroendocrinology | ECE2023

Characteristics of pituitary insufficiency in acromegaly: report on 28 cases

Abidi Sahar , Mekni Sabrine , Esseyah Sawssen , Cherchir Faten , Mchuirgui Nadia , Rojbi Imene , Nacef Ibtissem Ben , Khiari Karima

Introduction: Acromegaly is a rare condition secondary to the hypersecretion of GH, often by a pituitary adenoma, which can lead to hypopituitarism of varying degrees. Our study aimed to analyze the characteristics of pituitary insufficiency during acromegaly and to search for its predictive factors.Methods: Retrospective study carried out in the endocrinology department of Charles Nicolles Hospital. We recorded 28 patients with acromegaly over a period ...

ea0090ep773 | Pituitary and Neuroendocrinology | ECE2023

Metabolic profile during Sheehan’s syndrome

Boubagura Imane , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: – Sheehan syndrome (SS), or postpartum pituitary necrosis, is a rare but potentially serious complication of postpartum. – SS remains an important cause of hypopituitarism in Morocco.– The aim of this study is to evaluate the metabolic profile of patients with SS.Materials and methods: – This is a retrospective descriptive study conducted in the endocrinology department, spread over a period of 12 years, between the year...

ea0090ep774 | Pituitary and Neuroendocrinology | ECE2023

The role of artificial intelligence algorithm in predicting the prognosis in prolactinomas

Kara Zehra , Sulu Cem , Demir Ahmet Numan , Kadioglu Pinar

Objective: To test the utility of the artificial learning algorithms using magnetic resonance (MR) images of the pituitary gland in predicting the prognosis of prolactinoma.Methods: This single-center, retrospective study was conducted in the Pituitary Center of a tertiary care university hospital. A total of 224 images derived from 38 patients with treatment-refractory prolactinoma, 23 patients with prolactinoma remission and 51 healthy individuals were...

ea0090ep775 | Pituitary and Neuroendocrinology | ECE2023

Quality of life in acromegaly

Jemuovic Zvezdana , Djurovic Marina Nikolic , Djurdjevic Sandra Pekic , Miljic Dragana , Stojanovic Marko , Petakov Ana , Jovanovic Aleksandra , Grujicic Danica , Milojevic Toplica , Milicevic Mihailo , Stanimirovic Aleksandar , Gacic Emilija Manojlovic , Cekic Ivana , Petakov Milan

Introduction: Acromegaly is a rare chronic disease characterized by systemic comorbidity. As a chronic disease, which in most cases requires long-term treatment, it is often accompanied by musculoskeletal, metabolic, and cardiovascular diseases, as well as headaches, anxiety, and depression, which leads to impaired quality of life.Aim: Assessment of quality of life in patients with acromegaly compared to healthy controls.Materials ...

ea0090ep776 | Pituitary and Neuroendocrinology | ECE2023

Features of neuroendocrine, hormonal and ophthalmic complications of giant pituitary adenomas depending on the volume and growth of the tumor (data from a prospective study)

Urmanova Yulduz , Mirtukhtaeva Malika , Khodgaeva Feruza

Aim: To study features of neuroendocrine, hormonal and ophthalmic complications of giant pituitary adenomas depending on the volume and growth of the tumor (data from a prospective study).Material and methods: Us for the period from 2020 to 2022. 151 patients with macro- and giant NFPA were prospectively examined. According to the size of pituitary adenomas, patients of prospective (151 patients) observation were divided into 2 groups: group 1 – pat...

ea0090ep777 | Pituitary and Neuroendocrinology | ECE2023

Differential diagnosis of the progressing pituitary lesion in a pregnant woman

Ilovayskaya Irena , Mikhaylova Daria , Krivosheeva Yulia , Komerdus Irina

A 31-year-old female patient without previous history of pituitary diseases, at 16 weeks of 4th spontaneous pregnancy complained about severe headache; diplopia and right ptosis developed shortly, nausea and vomiting appeared. Brain MRI showed the mass lesion 30×19×14 mm (frontal×vertical×sagittal) with supra-laterosellar extension, deforming and displacing optic chiasm; signs of pansinusitis, pathological contents of the right mastoid cells, vascular malfo...

ea0090ep778 | Pituitary and Neuroendocrinology | ECE2023

Induction of secondary sexual characteristics with gonadotropins in an adult male with Kallman syndrome

Boix Jose Vicente Gil , Soler Guillermo Serra , Cubas Javier Bodoque , Raczkowski Meritxell Vines , Sanchez Alicia Sanmartin , Peris Andreu Campos , Font Mercedes Noval , Povedano Santiago Tofe , Jimenez Inaki Arguelles

Introduction: Hypogonadotropic hypogonadism is the cause of sexual deficiency, sometimes difficult to differentiate from constitutional growth delay (CGD).Clinical case: A 19-year-old male consulting endocrinology for delayed puberty. Pointed to, at 13 years of age, as having had CGD. His medical report include a viral meningitis at 8 years of age and anosmia since 3 years of age. He expressed lack of sexual desire and concern about the size of his genit...

ea0090ep779 | Pituitary and Neuroendocrinology | ECE2023

Mental health issues of patients with acromegaly: A systematic review

Murat Merve , Celik Selda , Ata Elvan Emine

Background: Acromegaly which is caused by excessive growth hormone is a rare chronicle endocrine disorder. Because it is a rare disorder, limited data are available on the impact and consequences of acromegaly on the mental health of patients, but the investigations are growing over time.Aim: It aims to summarize the evidence identifying the mental health issues of patients with acromegaly.Methods: MEDLINE (PubMed), Web of Science,...

ea0090ep780 | Pituitary and Neuroendocrinology | ECE2023

Gelastic seizures caused by pituitary stalk interruption syndrome: Case report

Yamna Hadami Ben , Najla Bchir , Abadlia Salma , Benchhida Annam , Zouaoui Chedia , Ouertani Haroun

Introduction: Gelastic seizures have been typically described with hypothalamic hamartomas and precocious puberty. Invasive EEG recordings have shown that gelastic seizures originated from the hypothalamic hamartomas, however recent findings have shown that they might also arise from other central lesions, like tumors, malformations of cortical development, postinfectious foci and other hypotalamic or pituitary abnormalities. In this case, we describe a patient with gelastic s...

ea0090ep781 | Pituitary and Neuroendocrinology | ECE2023

Macroprolactinoma in a patient with Schizophrenia: which illness should be treated first?

Chayma Bel Hadj Sliman , Najla Bchir , Myriam Baltagi , Benchhida Annam , Dorraelguiche Dorra , Chadia Zouaoui , Ouertani Haroun

Introduction: Prolactinomas are the most common of functional pituitary tumors. Dopamine agonists are the first line treatment of prolactinomas but have antagonistic effect with antipsychotics (dopamine receptor blockers) used in schizophrenia. The association between these two illnesses is a medical challenge, as the treatment of one disease can exacerbate the symptoms of the other one.Clinical case: We report the case of a 72-year old man, newly diagno...

ea0090ep782 | Pituitary and Neuroendocrinology | ECE2023

Prolactinoma in women

Salhi Asmae , Jamal Anouar , Bakmizi Hanae , Rachedi Hanae , Rouf Siham , Latrech Hanane

Introduction: Prolactinoma is the most common type of pituitary adenoma, but it still presents difficulties in management especially in women who present some particularities hence the interest of our study.1Material and method: This is a retrospective, descriptive study including 14 patients, hospitalized in the Endocrinology-Diabetology-Nutrition Department at CHU-Mohammed-VI-Oujda, between 2016–2022. The statistical analysis was perfor...

ea0090ep783 | Pituitary and Neuroendocrinology | ECE2023

Radiological features of non-functioning pituitary adenomas in the Tunisian population

Missaoui Abdel Mouhaymen , Majdoub Nabila Rekik , Soomauroo Siddiqa , Akid Faten Haj Kacem , Salah Dhoha Ben , Mnif Fatma , Charfi Nadia , Mnif Mouna , Elleuch Mouna , Abid Mohamed

Objective: To describe the radiological features of non-functioning pituitary adenomas (NFPA) at diagnosis.Patients and methods: A retrospective descriptive study of 35 patients followed for NFPA between 2000 and 2022. A pituitary magnetic resonance imaging (MRI) scan was performed in all patients.Results: The mean age was 52.1±11.4 years with a male predominance (61.3%). Pituitary tumor syndrome was the main reason for consul...

ea0090ep784 | Pituitary and Neuroendocrinology | ECE2023

Cushing’s disease with negative imaging: What diagnostic and therapeutic approach?

Maya Sadi , Mezoued Mouna , Khadidja Bessaid , Azzouz Malha

Introduction: Cushing’s disease with negative hypothalamic–pituitary imaging is not a rare situation, since it is found in 1/3 of cases. This is a situation that complicates the etiological and therapeutic approach of the pathology, questioning the practitioner as to the effectiveness of pituitary surgery in this case.Objective of the study: The aim of our study was to compare the results of pituitary surgery in the groups of patients with and ...

ea0090ep785 | Pituitary and Neuroendocrinology | ECE2023

Acromegaly and metabolic comorbidities – a retrospective study

Dumitras Teodor , Duta Simona Gabriela , Calapod Ruxandra , Bancu Alexandra , Nistor Irina , Sirbu Anca , Martin Sorina , Barbu Carmen , Fica Simona

Introduction: Acromegaly is a rare endocrine disease characterised by excess GH produced by a pituitary adenoma. It is associated with several complications and comorbidities. Metabolic alterations such as diabetes and dyslipidemia are quite frequent described in these patients.Materials and methods: This is a retrospective observational cross-sectional study meant to assess the metabolic modifications in a group of acromegaly patients evaluated in our d...

ea0090ep786 | Pituitary and Neuroendocrinology | ECE2023

De-escalation treatment with pasireotide for aggressive acromegaly: A long-term experience

Menotti Sara , Giampietro Antonella , Chiloiro Sabrina , Pontecorvi Alfredo , De Marinis Laura , Bianchi Antonio

Introduction: Pasireotide long acting release (LAR) is approved for second line treatment of acromegaly. We present 3 patients with aggressive acromegaly treated with a personalized de-escalation approach.Case 1: A 61-year-old female affected by acromegaly reisistant on first-line SSAs. In 2015 therapy was switched to pasireotide LAR 60 mg every 28 days. After two years, the IGF-I level touched the lower age range and therapy was downscaled to pasireotid...

ea0090ep787 | Pituitary and Neuroendocrinology | ECE2023

Somatotrpic adenomas: Radiological features at diagnosis in a Tunisian cohort

Akid Faten Haj Kacem , Belabed Wafa , Missaoui Abdel Mouhaymen , Salah Dhoha Ben , Mnif Mouna , Mnif Fatma , Mejdoub Nabila , Abid Mohamed

Background and aim: Acromegaly is mostly due to a somatotropic adenoma. Regarding its insidious nature, this adenoma is often revealed at an invasive stage. This study aims to describe the radiological specificities of somatotropic adenomas at the time of diagnosisPatients and methods: We conducted a retrospective study at the Endocrinology department of Hedi Chaker University Hospital, Sfax, Tunisia. We involved 29 patients diagnosed with acromegaly, wh...

ea0090ep788 | Pituitary and Neuroendocrinology | ECE2023

Prolactinoma in men

Salah Dhoha Ben , Souleima Trigui , Hamdi Frikha , Charfi Nadia , Mnif Mouna , Mejdoub Nabila , Mnif Fatma , Akid Faten Haj Kacem , Abid Mohamed

Introduction: Prolactinomas in men are rare but are characterised by their giant and invasive nature. They present with signs of hypogonadism and mass effect. The aim of this study is to clarify the clinical, biological, radiological and therapeutic features of Prolactinomas in men.Patients and methods: Retrospective descriptive study including 27 adult males with a prolactin pituitary adenoma hospitalized in the endocrinology department of the Hedi Chak...

ea0090ep789 | Pituitary and Neuroendocrinology | ECE2023

Diagnostic approach and treatment options for a geriatric patient with panhypopituitarism due to pituitary apoplexy

Shonia Natia , Chanturishvili Ketevan , Margvelashvili Natia , Zavrashvili Nino , Gvazava Qetevan

Pituitary apoplexy (PA) is a rare clinical syndrome related to abrupt hemorrhage and/or infarction of the pituitary gland, usually occurring in patients with preexisting pituitary disease. It is an endocrine emergency requiring rapid diagnosis and appropriate management. Pituitary apoplexy may lead to multiple pituitary hormone deficiencies. Without proper diagnosis and management, these can lead to the occurrence of irreversible complications, most significantly adrenal crisi...

ea0090ep790 | Pituitary and Neuroendocrinology | ECE2023

Werner syndrome and endocrine involvement: A case report

Slama Nassim Ben Hadj , Saad Ghada , Asma Gorchene , Ach Taieb , Kacem Maha , Ach Koussay

Introduction: Werner syndrome is a rare genetic disease affecting the WRN gene, of autosomal recessive inheritance.Case-presentation: We report the case of a 34-year-old patient who presented with erectile dysfunction and asthenia. His brother underwent surgery for meningioma. He was also diagnosed with hypogonadism, suffered from bilateral cataract and diabetes, and died following acute Leukemia at the age of 35 years. Our patient is from a second-degre...

ea0090ep791 | Pituitary and Neuroendocrinology | ECE2023

Pituitary formation according to the results of magnetic resonance imaging studies

Brutskaya-Stempkovskaya Elena , Dydyshka Yuliya , Kavetski Siarhei , Vasilevich Ivan , Alperyn Artsiom

Objective: The introduction of imaging technologies into routine clinical practice has increased the pituitary incidentalomas cases detection by magnetic resonance imaging (MRI) of the brain. Identification of pituitary formations requires additional hormonal examination and dynamic MRI pituitary examination for differential diagnosis and treatment strategy for patients. An important clinical problem is to determine the malignancy, predictors of potential growth and hormonal a...

ea0090ep792 | Pituitary and Neuroendocrinology | ECE2023

Pituitary pathology and pregnancy

Leila Belhadi , Salma Bensbaa , Haraj Nassim Essabah , El Aziz Siham , Chadli Asma

Introduction: Pregnancy in patients with pituitary pathology is a rare and delicate situation. However, risks for the mother and the foetus as well as the consequences of pregnancy on the history of pituitary adenoma require close monitoring.Goals: Illustrate through 5 observations the evolution of pituitary pathology during pregnancy.Observations: 1st patient: 41-year-old followed for somatotropic pituitary macro ...

ea0090ep793 | Pituitary and Neuroendocrinology | ECE2023

Metabolic complications of acromegaly: About 62 cases

Harouna Nana Aichatou , Haraj Nassim Essabah , El Aziz Siham , Chadli Asma

Introduction: Metabolic disorders caused by acromegaly are responsible for three times the morbidity of the general populationStudy objectives: To analyze the different metabolic complications in acromegalic patients.Materiel and methods: This is a retrospective study of 62 cases of acromegaly followed at the Department of Endocrinology and Metabolic Diseases CHU IBN ROCHD from January 2005 to December 2022. The data analysis was d...

ea0090ep794 | Pituitary and Neuroendocrinology | ECE2023

MAFLD prevalence in a cohort of patients with Cushing’s disease

Remon Pablo , Gutierrez Ana Pinar , Moreno Eva Venegas , Dios-Fuentes Elena , Gonzales David Cano , Romero-Gomez Manuel , Soto-Moreno Alfonso

Objectives: To describe the prevalence of liver steatosis in a cohort of patients with Cushing’s disease.Methods: Cross-sectional descriptive study. We included 59 patients with Cushing’s disease from our cohort of patients who underwent a Fibroscan to analyze the degree of hepatic steatosis (CAP measured in dB/m) and liver fibrosis (fibrosis measured in kPa). Biochemical algorithms of liver steatosis and fibrosis were assessed.<p class="ab...

ea0090ep795 | Pituitary and Neuroendocrinology | ECE2023

Coexistence of acromegaly and autoimmune disorders: Between hazard and causality – a case series

Iftimie Mădălina Elena , Iulia-Florentina Burcea , Dobre Ramona , Trifanescu Raluca , Niculescu Dan Alexandru , Baciu Ionela , Radian Serban , Capatana Cristina , Poiana Catalina

Introduction: Acromegaly is a rare, chronic endocrinopathy, that results from persistent hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor 1 (IGF1). It is well known that GH excess has multisystemic effects throughout the body, but its interaction with the immune system has only been suggested in the last few decades. This prompted us to explore the frequency of autoimmune disorders in a retrospective acromegaly cohort....

ea0090ep796 | Pituitary and Neuroendocrinology | ECE2023

Octreotide and pasireotide LAR in non-functioning pituitary neuroendocrine tumours treatment

Bogusławska Anna , Kluczyński Łukasz , Godlewska Magdalena , Rzepka Ewelina , Hubalewska-Dydejczyk Alicja , Gilis-Januszewska Aleksandra

Somatostatin analogues (SSA) are first/second line treatment in the management of acromegaly and Cushing disease (CD), however, recent data suggest that they can be effective in the management of non-functioning pituitary neuroendocrine tumour (PitNET). We present one clinically silent gonadotroph PitNET treated with octreotide and two silent corticotroph PitNETs treated with pasireotide.Case 1: A 50-year-old female presented with frontal headache and vi...

ea0090ep797 | Pituitary and Neuroendocrinology | ECE2023

Pituitary stalk interruption syndrome: A rare and severe cause of hypoglycemia in the newborn

Akioud Fatima , Moustaghit Imane , Abourazzak Sana

Introduction: Pituitary Stalk Interruption syndrome (PSIS) is a congenital anomaly of the pituitary gland responsible for isolated or combined anteropituitary insufficiency. We report a case of Pituitary Stalk Interruption Syndrome (PSI) diagnosed in a newborn with profound hypoglycemia.Case report: We report the case of a newborn with hypotonia, neonatal jaundice associated to a micropenis and a bilateral cryptorchidia. Because of severe hypoglycemia at...

ea0090ep798 | Pituitary and Neuroendocrinology | ECE2023

Pituicytoma in 64 years old man

Barmpa Eleftheria , Meleti Ioanna , Pappa Dimitra , Efraimidis Grigorios , Bargiota Alexandra

Introduction: Pituicytoma is a rare, primary benign, tumor of the sellar and suprasellar regions which is arising from pituicytes of the neurohypophysis and infundibulum and mainly affects middle age adults. We present here such a casePresentation: A 64-years-old man was referred to our clinic. For further investigation of a sellar lesion with suprasellar extension. The patient underwent investigations due to visual disturbances which he noticed initiall...

ea0090ep799 | Pituitary and Neuroendocrinology | ECE2023

Craniopharyngiomas in adult patients: Retrospective, multicentric study in Buenos Aires, Argentina

Mallea-Gil Susana , Glerean Mariela , Rogozinski Amelia , Ballarino Carolina , Battistone Maria Florencia , Danilowicz Karina , Diez Sabrina , Day Patricia Fainstein , Furioso Alejandra , Guitelman Mirtha , Katz Debora , Loto Monica , Martinez Marcela , Miragaya Karina , Sosa Soledad , Slavinsky Patricia , Tkatch Julieta , Vitale Marcelo , Pernas Valeria Gonzalez , Roel Valeria Garcia , Pingel Jesica

Craniopharyngiomas are rare lesions derived from cell remnants of Rathke’s pouch, usually localized in the sellar and suprasellar areas.Objectives: To analyze clinical, endocrine and histological features in a group of patients from Buenos Aires city. To assess efficacy, number of surgeries and complications after surgery or other treatments.Material and methods: Multicentric, retrospective, transversal study. Adult patients w...

ea0090ep800 | Pituitary and Neuroendocrinology | ECE2023

Metastatic insulinoma in MEN1 patient

Havlinova Barbora , Soukup Jiri , Hovorkova Eva , Cap Jan

We present a case report of a 56-year-old woman with MEN1 syndrome diagnosed at the age of 28 years. It was completely expressed by the set – insulinoma, prolactinoma and primary hyperparathyroidism. She underwent resection of 2/3 of the pancreas for symptomatic hypoglycaemia in the age of 28 years (1991). After two resections of parathyroid glands hypocalcaemia replacement was necessary. Prolactinoma was transiently treated with dopamine agonists. In the age of 45 years ...

ea0090ep801 | Pituitary and Neuroendocrinology | ECE2023

An Open-Label Extension Study to Evaluate the Safety of Long-term Use of Relacorilant in Patients With Endogenous Cushing Syndrome

Badiu Corin , Mariash Cary N. , Kautzky-Willer Alexandra , Shlomai Gadi , Aresta Carmen , Pivonello Rosario , Dischinger Ulrich , Bancos Irina , Dobri Georgiana , Hamrahian Amir , Auchus Richard , Feelders Richard , Recasens Monica , Chmiel-Perzynska Iwona , Pearson Emily , Moraitis Andreas G. , Araque Katherine

Cushing syndrome (CS) is a chronic and debilitating condition with high morbidity and mortality. Development of novel, safe, and effective pharmacologic therapies with improved risk-benefit profiles would enrich treatment options for patients. Relacorilant is a selective glucocorticoid receptor (GR) modulator that competitively antagonizes cortisol activity and, unlike the FDA-approved GR antagonist mifepristone, does not bind to the progesterone receptor. In a phase 2 study i...

ea0090ep802 | Pituitary and Neuroendocrinology | ECE2023

Diagnostic and therapeutic challenges in cyclic Cushing’s syndrome: A systematic literature review

Nowak Elisabeth , Vogel Frederick , Albani Adriana , Braun Leah , Rubinstein German , Zopp Stephanie , Ritzel Katrin , Beuschlein Felix , Theodoropoulou Marily , Reincke Martin

Background: Cyclic Cushing’s syndrome (cCS) is a sub-entity of Cushing’s syndrome (CS) associated with diagnostic and therapeutic challenges. It describes a condition, in which phases of clear-cut biochemical hypercortisolism are followed by spontaneous troughs of normal or subnormal cortisol secretion. We conducted the first systematic literature review to identify common features of cCS.Methods: We searched MEDLINE (via PubMed) for eligible s...

ea0090ep803 | Pituitary and Neuroendocrinology | ECE2023

Rheumatologic complications of acromegaly

Magouri Oumaima , Zarraa Lamiae , Elmehraoui Ouafae , Rouf Siham , Latrech Hanane

Introduction: The osteoarticular complications of acromegaly are among most disabling impacts, and can be explained by two mechanisms, chronic exposure to high levels of GH and IGF1 leading to increased bone turnover, hypertrophy and osteocartilaginous degeneration, as well as the gonadal insufficiency observed during acromegaly may aggravate the situation. The objective of this study is to describe the rheumatological manifestations of acromegaly.Materi...

ea0090ep804 | Pituitary and Neuroendocrinology | ECE2023

Correlation Betwen Obesity in Patients with A Diagnosis of Non-Functioning Adenomas and Prolactinomas

Baquero Stefany , Quishpe Lopez Darlyng , Freire Salazar Gabriela , Luis Salazar Vega Jorge , Ruiz Urbaez Rossana , Villota Acosta Xavier

Background : Obesity is a chronic and complex health problem. Although it is a preventable health risk factor, it´s prevalence has grown rapidly in recent years. There are studies that demonstrate the relationship between hyperprolactinemia and obesity. However, it is not well explained and the results are contradictory. The objective of this study was to evaluate the relationship between increased prolactin and Body Mass Index (BMI) in patients with pituitary macroadenom...

ea0090ep805 | Pituitary and Neuroendocrinology | ECE2023

Secondary amenorrhea revealing pituitary sarcoidosis: a case report and review of the literature

Fatima Ezzahra Mennani , Camara Mballou , Rafi Sana , Elmghari Ghizlane , EL Ansari Nawal

Introduction: Hypothalamic-pituitary involvement during sarcoidosis is rare, less than 1%. Granulomatous infiltration can lead to anteropituitary insufficiency, disconnection hyperprolactinemia and diabetes insipidus. We report a case of hypothalamic-pituitary sarcoidosis with review of the literature.Observation: Patient aged 39 years, she complains of chronic headaches for 10 months without decrease in visual acuity, secondary amenorrhea for 6 months. ...

ea0090ep806 | Pituitary and Neuroendocrinology | ECE2023

Analysis of The Modulating Effect of Melatonin on Reproductive Processes and Cognitive Potential Under Conditions of Chronic Inflammation Using The Model of Estrous Cycles of Sexually Mature Female Rats

Tchang Aisance , Naimushina Lada , Lemba Yves , Belyakov Vladimir

Introduction: Reproductive processes are regulated with the participation of the kisspeptinergic neurotransmitter system and the hormonal axis hypothalamus – adenohypophysis – gonads. The action of all regulators of reproductive processes can be disturbed by the development of inflammation and the action of pro-inflammatory cytokines. In this case, cognitive dysfunctions may occur, since sex hormones are involved in the regulation of brain functions. The study analyz...

ea0090ep807 | Pituitary and Neuroendocrinology | ECE2023

Co-occurrence of premature ovarian insufficiency and Rathke Cleft Cyst: case report

Ben Yamna Hadami , Chiboub Marwa , Naccache Emna , Gharbi Radhouane , Jemel Manel , Kammoun Ines

Introduction: Rathke cleft cysts (RCC) are benign cystic lesions of the sellar and suprasellar region, which is believed to arise from the remnants of the Rathke pouch. Symptomatic RCC are rare. Endocrine symptoms are usually caused by compression of the surrounding pituitarygland. It can therefore cause hypopituitarism, but it is rarely associated with primary endocrine dysfunctions. In this case, we report a co-occurrence of premature ovarian insufficiency and RCC.<p cla...

ea0090ep808 | Pituitary and Neuroendocrinology | ECE2023

Infectious manifestations during neuro-gastrointestinal mitochondrial encephalopathy: about 2 patients

Nabil Lachiheb , Ines Bartegi , Ichrak Bougharriou , Hmida Salma Ben , Kacem Faten Hadj , Mouna Mnif , Mohamed Abid

Introduction: Mitochondrial neuro-gastro-intestinal encephalopathy (MNGIE) is a rare autosomal recessive disease caused by a mutation in the TYMP gene.Patients-methods: Retrospective study including 2 cases (brother and sister) followed for MNGIE confirmed by genetic study at the endocrinology department of Sfax.Results: -> 1st case: 25-year-old man, follow-up for diabetes, dilated cardiomyopathy, renal lithiasis, MNGIE.<p ...

ea0090ep809 | Pituitary and Neuroendocrinology | ECE2023

The importance of Prompt Treatment of Ectopic Cushing Syndrome

Meira Ines , Menino Joao , Pedro Jorge , Carvalho Davide , Freitas Paula

Introduction: Ectopic ACTH production accounts for up to 20 percent of ACTH-dependent Cushing syndrome (CS). Small cell carcinoma and carcinoid of the lung represents half of its cases. These patients lack some of the more obvious clinical features of cortisol excess. Therefore, this can cause a delay in the diagnosis of CS and these patients may be at high risk of life-threatening complications such as infections or thrombosis.Clinical case: Case of a 7...

ea0090ep810 | Pituitary and Neuroendocrinology | ECE2023

Challenges in treatment of carotid paraganglioma : About a case report

Sara Chtioui , Meryam Alhyane , Rafi Sana , Mghari Ghizlane El , Ansari Nawal El

Introduction: Carotid body tumor is a hypervascular tumor with multiple feeding arteries and unique orientation at the carotid bifurcation. Although resection is a radical therapy for this tumor, complete resection is challenging.Case report: A 33-year-old female patient consulted with a neck swelling that had persisted for 3 years. On physical examination, a movable and pulsating hard mass was found on the left side of her neck. Computed tomography, mag...

ea0090ep811 | Pituitary and Neuroendocrinology | ECE2023

A Rare Case of recurrent Hypoglycaemia

Aslam Aisha , Lewis Alex

Insulinomas, uncommon neuroendocrine tumours, may produce insulin-induced hypoglycemia. It causes neuroglycopenia and autonomic sympathetic dysfunction. Glucose immediately relieves these sensations. Hypoglycemia without plasma sulfonylurea and increased C-peptide is diagnostic. The tumour must be found before surgery.Introduction: Hypoglycemia is caused by insulinomas. Insulinoma, the most frequent functional pancreatic tumour, occurs just four times pe...

ea0090ep812 | Pituitary and Neuroendocrinology | ECE2023

Adolescent Acromegaly : About 2 Case Studies

Mireille Uwimana Alida , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Acromegaly is an unusual disease in adolescence. Its diagnosis and management are a challenge in this population. Here we report 2 rare cases of acromegaly in this age group.Patients and Observations: Observation 1: This is a 17 year old patient admitted for acromegaly on pituitary microadenoma measuring 4*3mm who presents a symptomatology made of an accentuation of the growth rate, thin and long limbs, elongated hands and ...

ea0090ep813 | Pituitary and Neuroendocrinology | ECE2023

Craniopharyngioma masquerading as a suprasellar Rathke cleft cyst in a young patient with a history of Ewing sarcoma: A case report

Ioana Ruxandra Calapod , Cima Luminita , Mirica Alexandra , Ulpia Comsa Codruta , Dragomir Monica , Stoica Sergiu , Fica Simona

Craniopharyngiomas are rare, benign tumors, typically found in childhood or early adulthood, that can cause a wide range of symptoms such as visual impairment, headaches, nausea and endocrine disturbances. Ewing sarcoma, on the other hand, is a rare and aggressive tumor that arise from primitive neuroectodermal cells and represents about 10% of all pediatric osseous primary tumors. We present the case of a 14-year-old patient who was admitted to our clinic in March 2022 for ob...

ea0090ep814 | Pituitary and Neuroendocrinology | ECE2023

Short stature caused by pituitary stalk interruption syndrome in a type 1 diabetic child: a case report

Ben Yamna Hadami , Najla Bchir , Benchhida Annam , Abadlia Salma , Zouaoui Chedia , Ouertani Haroun

Introduction: Pituitary stalk interruption syndrome is a rare disorder characterized by a specific tirade: an absent or hypoplastic anterior pituitary gland, thin or absent infundibulum, and ectopic posterior pituitary location. This syndrome has been described in association with other somatic abnormalities and recently a polygenic etiology has been suggested. Herein, we report a case of type 1 diabetic patient, explored for short stature, revealing a pituitary stalk interrup...

ea0090ep815 | Pituitary and Neuroendocrinology | ECE2023

Desmopressin or decompensated corticotropic insufficiency: who is the guilty party in profound hyponatremia?

Halouache Ali , Khamel Ghita , Jad Isouani , Ahmed Anas Guerboub

Introduction: We report the case of a patient with corticotropic insufficiency associated with diabetes insipidus who presented to the emergency room with profound hyponatremia; a complicated situation, whose solution was hidden in the galenic form of Desmopressin.Case report: Mrs Y. Amina, 37 years old, has been followed for 10 years for a non Langerhansian histiocytosis of pituitary location, complicated by a corticotropic insufficiency under hydrocort...

ea0090ep816 | Pituitary and Neuroendocrinology | ECE2023

A Rare Pituitary Pathology: Patient With Crooke Cell Corticotroph Adenoma

Yiğit Koroğlu Ekin , Aydin Cevdet , Keskin Caglar , Faruk Turkoğlu Omer , Gureşci Servet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

However ACTH secreting adenomas are one of the most common functional pituitary tumors, subtypes such as Crooke cell corticotroph adenoma(CCCA) are relatively rare. We present here a patient with CCCA who had severe hypercortisolism mimicking ectopic ACTH syndrome. A 69 years old female patient admitted to emergency department after a fall. On cranial MRI,’a 3.5x2.5x3cm mass appearance with a sellar-suprasellar location, which is compressing the optic chiasm, expanding th...

ea0090ep817 | Pituitary and Neuroendocrinology | ECE2023

Contribution of MRI to the diagnosis of hypophysitis

Benouda Siham , Derbel Salma , Zeryouh Nabila , Rouf Siham , Latrech Hanane

Introduction: Hypophysitis is a rare condition corresponding to a chronic inflammation of the pituitary gland, The clinical and radiological signs are not specific and the pathogenesis remains poorly elucidated. The aim of our work is to report the clinico-radiological aspects of hypophysitis.Material and Methods: This is a retrospective descriptive study of 09 patients hospitalized in the department of Endocrinology-Diabetology-Nutrition of Mohammed-VI ...

ea0090ep818 | Pituitary and Neuroendocrinology | ECE2023

A Pituitary Neoplasm with an Aggressive Course: Silent Corticotroph Adenoma

Yiğit Koroğlu Ekin , Houssein Mehdi , Tural Balsak Belma , Bahadır Burak , Gureşci Servet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Patient is a 43 years old female without any known additional disease. A pituitary mass was seen in the cranial MRI taken due to the complaint of forgetfulness. Pituitary MRI of the patient revealed a ’large intrasellar mass of 3.2x3x2.3 cm, which expanded the sella and pressed the optic chiasm’. The patient didn’t describe any symptoms other than forgetfulness. She didn’t have galactorrhea, cushingoid or acromegaloid appearance. Patients laboratuary evalua...

ea0090ep819 | Pituitary and Neuroendocrinology | ECE2023

Noonan syndrome associated with SOS1 gene mutation with autosomal dominant RASopathy : a case report

El Hafiani Asmae , Azriouil Manal , Echchad Lamya , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamedelhassan

Introduction: Noonan syndrome (NS) is an autosomal dominant genetic disorder characterized by the combination of facial dysmorphia, short stature and congenital heart disease. The mutation of the PTPN11 gene is present in 50% of cases, recently the mutation of other genes was found, notably KRAS and SOS1. We report the case of a patient followed in our department for NS with a SOS1 gene mutation.Case report: A 4 years old male patient, referred to our de...

ea0090ep820 | Pituitary and Neuroendocrinology | ECE2023

Delayed diagnosis of idiopathic growth hormone deficiency in children

Alassaf Abeer , Odeh Rasha

Background: The delay of diagnosis of idiopathic growth hormone deficiency (GHD) in children, would result in delayed management, and would significantly affect final adult height.Methods: This was a retrospective chart review study for patients seen at the pediatric endocrine clinic at the Jordan University Hospital, over a period of six years. Demographic, clinical, auxological and hormonal characteristics were studied.Results: T...

ea0090ep821 | Pituitary and Neuroendocrinology | ECE2023

Comparison between insulin tolerance test and clonidine stimulation test in the exploration of growth hormone deficiency

Abadlia Salma , Najla Bchir , Zouaoui Chadia , Ben Yamna Hadami , Ben Chehida Anaam , Ouertani Haroun

Introduction: Growth hormone deficiency (GHD) is a rare cause of delay of growth. However, it is primordial to screen for it since its presence leads to a specific treatment which improves statural prognosis. GHD should be confirmed through stimulation tests such as Insulin Tolerance test (ITT) or Clonidine Stimulation Test (CST). The objective of our study was to compare these two diagnostic tools.Methods: We conducted a retrospective study in the endoc...

ea0090ep822 | Pituitary and Neuroendocrinology | ECE2023

Polyuria-polydipsia syndrome revealing primary potomania : a diagnostic challenge

Lassoued Najoua , Zaouali Fatma , Abid Arige , Abdelkafi Yassmine , Alzir Mahmoud , Baha Zantour , Mohamed Habib Sfar

Introduction: Polyuria-polydipsia syndrome (PUPDS) requires a comprehensive diagnostic approach as it can reveal serious medical conditions. We report the case of a patient consulting for PUPDS related to a primary potomania. Case presentation: A 41-year-old patient with a history of multiple psychostimulants use was admitted for acute PUPDS after emotional shock and paucisymptomatic SARS-CoV-2 infection. Diuresis was estimated at 6 liters per 24 hours. ...

ea0090ep823 | Pituitary and Neuroendocrinology | ECE2023

Wolfram Syndrome: Case report

Salem Maram Ben , Chiboub Marwa , Adel Meriem , Jemel Manel , Kammoun Ines

Background: Wolfram syndrome is an autosomal recessive neurodegenerative disease. It is secondary to the mutation of WFS1 gene. It combines a tetrad of pathologies known also as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness). Case presentation: We report a case of 31-year-old women with medical history of type 1 diabetes since the age of 3 years old. She suffered from decreased visual acuity since the age of 5 years old and t...

ea0090ep824 | Pituitary and Neuroendocrinology | ECE2023

A case of a persistent hypernatremia secondary to adipsic central diabetes insipidus

Salhi Salma , Oueslati Ibtissem , Ben Hamida Asma , Abidi Sahar , Grassa Anis , Yazidi Meriem , Chihaoui Melika

Introduction: Central diabetes insipidus is a rare condition that typically manifests as polyuria-polydipsia syndrome. Polydipsia helps to maintain normal natremia. Herein, we report the case of persistent hypernatremia in a patient admitted for inaugural diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome.Observation : A 53-year-old woman was referred to our department for inaugural diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome...

ea0090ep825 | Pituitary and Neuroendocrinology | ECE2023

Pituitary cystic images: difficult diagnosis

Amel Rahal

Introduction: The most frequent cystic lesions in the pituitary region are: cystic adenomas, Rathke’s pouch cysts and craniopharyngiomas. But sometimes the diagnosis can be difficult.Clinical case: This is the case of a women patient who consulted at the age of 20 for a pituitary cystic process revealed by secondary amenorrhoea; evoking in the first place a Rathke’s pouch cyst. Hormonal assessment reveals tumour-related hyperprolactinemia; the ...

ea0090ep826 | Pituitary and Neuroendocrinology | ECE2023

Cushing’s disease in children: review of 3 cases

Amel Rahal , Akli Lylia

Introduction: Cushing’s disease is defined as hypercortisolism caused by excessive secretion of ACTH from a pituitary adenoma. Cushing’s disease is a rare entity in childrenObservation: We report the case of 3 children with Cushing’s disease including 2 boys and 1 girl, the mean age at the diagnosis was 12.6 years. Clinically, weight gain was constant in all children, a delay in statural growth was noted in 2 children, signs of catabolism ...

ea0090ep827 | Pituitary and Neuroendocrinology | ECE2023

Resistant to treatment prolactinoma: report of two cases

Lachkhem Aicha , Yahi Abdelkader , Katia Benabdelatif , Derriche Abderrahim , Kablia Samia Ould , Staifi Ahcen , Derradji Hakim

Introduction: Prolactin-secreting tumors or prolactinomas comprise the most common pituitary tumor type, acconting of 47-66% of all pituitary tumors. These tumors can be treated with dopaminergic drugs (DA) however 10-15% of prolactinomas are DA resistant.Case 1: A 39 years old man followed for a geant agressif prolactinoma discovered following a progressive decline in visual acuity and associated with visual impairment (diplopia), the MRI of the sellar ...

ea0090ep828 | Pituitary and Neuroendocrinology | ECE2023

Panhypopituitarism of unknown aetiology in a young adult – a case report

Souteiro Pedro , Santos Sara , Oliveira Joana , Inacio Isabel , P Santos Ana , Torres Isabel

Introduction: Hypopituitarism is a rare diagnosis that is mainly due to primary pituitary neoplasms and their treatment. There are rarer causes such as hemorrhage/ischemia, traumatic brain injury, infections and infiltrative lesions. Clinical case: We herein present an 18-year-old male patient diagnosed with acute promyelocytic leukemia at the age of 14, with no evidence of central nervous system invasion in several lumbar punctures during his follow-up....

ea0090ep829 | Pituitary and Neuroendocrinology | ECE2023

Central diabetes insipidus caused by a Lymphocytic infundibuloneurohypophysitis

Dokmetaş Meric , Demir Esra , Cağrı Karcı Alper , Sebile Dokmetaş Hatice , Zeynep Ağaoğlu Hikmet , Eren Esma , Şahin Onur , Akkoyun Ayşenur

Lymphocytic infundibuloneurohypophysitis (LINH) is rarely reported due to lymphocyte infiltration in the neurohypophysis. Causes of central diabetes insipidus include idiopathic diabetes insipidus (DI), primary or secondary tumors or infiltrative diseases (such as Langerhans cell histiocytosis, lymphocytic hypophysitis), neurosurgery and trauma.Case: A 59-year-old female patient presented with complaints of fatigue for 1 month, dry mouth and drinking a l...

ea0090ep830 | Pituitary and Neuroendocrinology | ECE2023

Two diabetes insipitus cases due to Langerhans cell histiocytosis

Sebile Dokmetaş Hatice , Şahin Onur , Zeynep Ağaoğlu Hikmet , Eren Esma , Akkoyun Ayşenur , Dokmetaş Meric , Kaan Turk Oğuz

Introduction: Langerhans cell histiocytosis (LCH) is a neoplastic histiocytic disorder that characterized by proliferation of abnormal Langerhans cells. The most typical organs affected by LCH are the skin and bones, though it can also affect the pituitary gland, central nervous system, liver, spleen, lungs, and other organs.Case 1: 36 year old man presented with polyuria, polydipsia and right hip pain lasting about 4 months. The pain increased in the la...

ea0090ep831 | Pituitary and Neuroendocrinology | ECE2023

Pituitary Abscess – A challenge to diagnose preoperatively

Ahmad Waqar , Nichols Matthew , Johnson Karen , Nicholson Claire , Mamoojee Yaasir , Joshi Ashwin

Background: Pituitary abscess is rare but a serious intrasellar infection. It should be considered in the differential diagnosis of the sellar masses due to its high morbidity and mortality rates. Despite recent advances in radiological investigations, it remains a challenge to make a definitive diagnosis preoperatively [1]. We present a case of pituitary abscess who presented with pan hypopituitarism and central diabetes insipidus.Case presen...

ea0090ep832 | Pituitary and Neuroendocrinology | ECE2023

An Atypical Presentation of Hypopituitrism

Minhas Raisa , Bashir Keefah , Mitchell Catherine , Ling Yong , Tarigopula Giridhar , Alansari Mustafa , Wernig Florian , Tomlinson James

A 48-year-old male presented with headache, cough and recurrent nose bleeds. Clinical examination showed saddle shape nose deformity. His past medical history included primary hypothyroidism diagnosed at the age of 10 years, was taking levothyroxine. His brother had a Rathke’s cleft cyst, surgically removed. His blood test were as follows: Sodium 125mmol/l, TSH 0.10mU/l, free T4 10.2pmol/l, freeT3 2.6pmol/l, cortisol < 28nmol/l, prolactin 240mU/l, FSH 1.8U/l, LH 0.3U/...

ea0090ep833 | Pituitary and Neuroendocrinology | ECE2023

Case Series of Cranial Diabetes Insipidus secondary to Presumed Lymphocytic Hypophysitis Presenting During Pregnancy

Sahota Shaan , Sinclair Lydia , Casey Edel , Mlawa Gideon , Otigbah Chineze , Akinlade Funmi , Pollock Jonathan , Stojanovic Nemanja

Introduction: We present two pregnant women who were referred to obstetric endocrinology service with polyuria and polydipsia. They were investigated and treated for diabetes insipidus (DI). In both cases, the underlying pathophysiology was ADH insufficiency secondary to autoimmune lymphocytic hypophysitis. There are currently no consensus guidelines on the diagnosis of DI during pregnancy. These cases highlight best practice and endorse MDT management of chronic hypopituitari...

ea0090ep834 | Pituitary and Neuroendocrinology | ECE2023

The Role of Medical therapy and Radiotherapy in the management of Pituitary Macroprolactinomas

English Robert , Ahuja Sanjali , Lowe Miriam , Khan Alaina , Hayat Maisha , Mahamud Bashir , Mlawa Gideon

Introduction: Background: Pituitary adenomas can be divided into functioning pituitary adenoma (FPA) and non-functioning pituitary adenoma (NFPA). Pituitary adenomas can also be classified based on their size as microadenoma(<1cm) or macroadenoma (>1cm).Cases: 1. A 33-year male was admitted with a 4-month history of headaches, generalized aches and pains, weight loss, lethargy, and erectile dysfunction. He was reviewed by t...

ea0090ep835 | Pituitary and Neuroendocrinology | ECE2023

Pituitary metastasis from colon cancer in a young patient

Ferreira Ana , Dias Angela , Raimundo Luisa

Introduction: Pituitary metastases account for approximately 1% of pituitary lesions, most frequently originating from lung or breast cancer. We describe a case of a pituitary metastasis from colon cancer, a rare origin.Case report: a 36 year-old male, previously healthy, came to the emergency department for new onset jaundice and fever. He also had headaches for the last 3 months, and for the last month diplopia, left palpebral ptosis and low libido. Ph...

ea0090ep836 | Pituitary and Neuroendocrinology | ECE2023

Clinical profile of Acromegaly patients in a teritary endocrine center in Kathmandu, Nepal

Joshi Ansumali , Khadka Smriti , Karmacharya Srijana , Shrestha Sushmita

Nepal has limited data on acromegaly patients. We did a retrospective study of acromegaly patients who were diagnosed in our center or were referred to our center. We included 10 patients of acromegaly who presented in our center from January 2018 to December 2022. Four (40%) were males and six (60%) were females. Their mean age was 38.70 +/- 6.51 years, ranging from 31 to 50 years. The mean BMI was 26.13+/-1.77 kg/m2. The most common presenting symptom was joint pa...

ea0090ep837 | Pituitary and Neuroendocrinology | ECE2023

Hyperprolactinemia in a patient with the kidney failure: a rare case of macroprolactinoma and autosomal dominant polycystic kidney disease

Majic Tengg Ana , Pandzic Jaksic Vlatka

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited kidney disease characterized by the development and growth of cysts causing a progressive kidney enlargement and the end-stage renal disease (ESRD). The incidence of brain aneurysms in patients with ADPKD is high thus screening is recommended. The association of pituitary incidentalomas and ADPKD is rarely described in the literature. All reported pituitary adenomas in patients with ADPKD were f...

ea0090ep838 | Pituitary and Neuroendocrinology | ECE2023

A sheehan’s syndrome revealed by cardiovascular collapse

Boubagura Imane , Hassan Neima , El Mghari Ghizlane , El Ansari Nawal

Introduction: Sheehan syndrome (SS), or postpartum pituitary necrosis, is a rare but potentially serious complication of postpartum. we describe a patient whose diagnosis of sheehan’s syndrome was delayed and revealed by a cardiovascular collapse.Case report: A 36 year old femele patient, admitted to the intensive care unit in a state of septic shock due to pyelonephritis, was intubated, ventilated and put on noradrenaline in SAP and antibiotic ther...

ea0090ep839 | Pituitary and Neuroendocrinology | ECE2023

Adipsic Diabetes Insipidus After Transsphenoidal Surgery for Suprasellar Intraventricular

Astafyeva Ludmila , Badmaeva Inna , Sidneva Yuliya , Klochkova Irina , Fomichev Dmitry , Chernov Ilya , Kalinin Pavel

Presented case demonstrates a rare diencephalic pathology — adipsic diabetes insipidus (ADI) with severe hypernatremia in a 58-year-old woman after ttranssphenoidal removal of stalk intraventricular craniopharyngioma. ADI was diagnosed because of hypernatremia (150–155 mmol/l), polyuria (up to 4 liters per day) and absence of thirst. Normalization of wa- ter-electrolyte balance occurred on the background of desmopressin therapy and sufficient hydration in postoperati...

ea0090ep840 | Pituitary and Neuroendocrinology | ECE2023

Severe hyponatremia in hospitalized patient caused by hypopituitarism due to empty sella

Tedoradze Nino , Akiashvili Nino , Kukuladze Nino , Dikhaminjia Otar

Background: Hyponatremia is the most common electrolyte disorder in clinical practice, whereas severe hyponatremia can be life-threatening if not diagnosed and managed appropriately. Severe hyponatremia can be the only presentation of several endocrine and non-endocrine diseases, and investigation for underlying causes and its appropriate management can be potentially life-saving. Severe hyponatremia is frequently overlooked as the presenting manifestation hypopituitarism. Her...

ea0090ep841 | Pituitary and Neuroendocrinology | ECE2023

Sheehan’s syndrome presenting as post-partum depression : a case report

Qasdi Ikrame , Echchad Lamya , Ouirar Hasna , Elmazuni Zainab , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamedelhassan

Introduction: Sheehan’s syndrome or Simmond’s disease is a partial or complete postpartum hypopituitarism caused by pituitary infraction and necrosis that usually occurs as a complication of massive postpartum hemorrhage or severe hypotension during or after labor and delivery. We present the case of Sheehan’s syndrome presenting postpartum depression. Case: A 40 years old woman, referred to our department by her psychiatrist for explorati...

ea0090ep842 | Pituitary and Neuroendocrinology | ECE2023

Spontaneous involution of a cystic pituitary adenoma

Zhao Montero Benitez Maria , Gonzalez Lazaro Paloma , Moreno Tirado Antonio , Jimenez Torrecilla Pedro , Contreras Pascual Cristina , Del Val Zaballos Florentino , Lomas Meneses Amparo , Gomez Garcia Ines

Pituitary adenomas (PAs) account for 15-20% of intracranial tumors. PA with a cystic component are characterized in the MRI by a sellar, symmetrical, round or ovoid mass that enhances on T1- or T2-weighted images but does not concentrate gadolinium. We present the case of a 48-year-old man who in a headache study by Neurology requested a CT scan showing a cystic pituitary macroadenoma of 1.25cm confirmed by pituitary MRI. In the initial analysis, the pituitary function was pre...

ea0090ep843 | Pituitary and Neuroendocrinology | ECE2023

Acromegaly: predictive factors for long-term remission

Faten Cherchir , Mekni Sabrine , Essayeh Sawsen , Abidi Sahar , Mchirgui Nadia , Rojbi Imen , Ben Nacef Ibtissem , Khiari Karima

Introduction: The management of acromegaly is commonly based on selective transsphenoidal adenomectomy (STA) as a first-line treatment, and other therapeutic options including somatostatin analogues (SA), dopamine agonists (DA) and radiotherapy as second-line treatment or in case of operative contraindications. The aim of our study was to assess the remission rate and to determine the predictive factors for long-term remission in acromegalic patients.Met...

ea0090ep844 | Pituitary and Neuroendocrinology | ECE2023

A case report of pituitary macroadenoma presenting with visual disturbance due to suspected cataract

Hussein Furhana , Cheung Man-Yan , Mlawa Gideon , Bashir Mahamud

Introduction: Pituitary adenomas are benign tumours of the pituitary gland with an estimated prevalence rate of approximately 17%. Around 1 in 600 people have macroadenoma (>1cm) that can present with variety of visual problems classically as bitemporal hemianopia due to compression of the optic chiasm.Case presentation: 50-year-old male was admitted with 3months history of worsening headache and 4months of visual disturbances. Initially he was seen ...

ea0090ep845 | Pituitary and Neuroendocrinology | ECE2023

Retrospective Evaluation of Pituitary Adenomas from clinical, laboratory and medical aspects

Kesebi Isganderov Duygu , Nur Kebabcı Medine , Yorulmaz Goknur , Akalın Aysen , Belgin Efe Fatma

Pituitary adenomas arise from adenohypophyseal cells and progress with increased comorbidity and mortality. It is important to examine the diagnosis, prevalence, course and treatment of the subgroups of the disease in our country because pituitary adenomas are seen in the most productive periods of life and have important clinical results. In our study, 667 pituitary adenoma patients who applied to Eskişehir Osmangazi University Medical Faculty Hospital Endocrinology Depa...

ea0090ep846 | Pituitary and Neuroendocrinology | ECE2023

Cyclic cushing syndrome: a case report

Ouakrim Hind , Dassoufi Rania , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Intermittent Cushing’s syndrome is characterized by alternating episodes of hypercorticism with periods of eucorticism. It is a rare but well-defined entity and should be known. It remains a diagnostic challenge sometimes particularly difficult in endocrinology, we report a case.Case presentation: A 22-year-old diabetic patient on metformin, who consulted us because of a weight gain with the appearance of stretch marks for 2 months. Th...

ea0090ep847 | Pituitary and Neuroendocrinology | ECE2023

Outcome of Bilateral Adrenalectomy in Cushing’s Syndrome

Sara Chtioui , Oussama Jaddi , Rafi Sana , Mghari Tabib Ghizlane El , El Ansari Nawal

Introduction: Cushing disease is the most common cause of endogenous hypercortisolism. Pituitary surgery is the first-line treatment and bilateral adrenalectomy is the option of last resort due to its severe consequences.Observation: This is a 24-year-old patient followed for cushing disease revealed by a severe cushing syndrome, a urinary cortisol at 20 times normal and negative dexamethasone suppression test with a pituitary microadenoma on MRI. He was...

ea0090ep848 | Pituitary and Neuroendocrinology | ECE2023

Opposite tumoral and hormonal responses to low-dose pasireotide in Cushing’s Disease

Serban Andreea , Zampetti Benedetta , Saladino Andrea , Chiodini Iacopo , Cozzi Renato

Pasireotide (Pas) is a multireceptor-targeted somatostatin analogue approved for the treatment of patients with Cushing’s Disease (CD) who fail or are poor candidates to surgery. Pas markedly improves signs and symptoms of the disease, reduces urinary free cortisol (UFC) up to its normalization in 55% of patients and pituitary tumour size in up to 100%. Here we present a patient with severe recurrent CD treated with Pas and showing opposite results between hormonal levels...

ea0090ep849 | Pituitary and Neuroendocrinology | ECE2023

Ophthalmological complications in acromegaly: prevalence and associated factors

Faten Cherchir , Mekni Sabrine , Essayeh Sawsen , Ben Hilel Wafa , Mchirgui Nadia , Rojbi Imen , Ben Nacef Ibtissem , Khiari Karima

Introduction: Somatotropin macroadenomas are associated with a considerable risk of ophthalmological impairment. The aim of our study was to determine the prevalence of ophthalmological complications and their associated factors in patients with acromegaly.Methods: We conducted a retrospective study including 28 patients with somatotropin adenomas and followed in the endocrinology department of Charles Nicolle Hospital. Clinical, biochemical and imaging ...

ea0090ep850 | Pituitary and Neuroendocrinology | ECE2023

Intrasellar arachnoid cysts – a benign entity with significant clinical impact: report of two cases

Iancu Cristina , Vladan Andreea , Bica Dorin , Radian Serban , Poiana Catalina

Introduction: Intrasellar arachnoid cysts are rare and clinically resemble nonfunctional pituitary adenomas. Arachnoid cysts should be considered in the differential diagnosis of cysts developing in the sellar region, together with cystic pituitary adenoma, craniopharyngioma, epidermoid cysts, and Rathke’s cleft cysts. Symptomatic cysts are operated but can recurr.Case presentation: We present 2 cases of compressive intrasellar arachnoid cysts occur...

ea0090ep851 | Pituitary and Neuroendocrinology | ECE2023

Echocardiographic features in patients with prolactinoma long-term treated with dopamine agonists

Carmen Giuca Diandra , Constantin Vere Cristin , Nitu Ileana , Capatina Cristina , Baciu Ionela , Florentina Burcea Iulia , Baculescu Nicoleta , Radian Serban , Simona Andreea Găloiu , Trifanescu Raluca , Poiana Catalina

Background: Dopamine agonists (DAs) were associated with valvular dysfunction in patients with Parkinson’s disease due to their fibrotic effect through the serotoninergic receptor. It is more difficult to prove the same effects in patients with prolactinoma due to the lower doses, variable doses and the longer follow-up period. Aim: To assess echocardiographic features in patients with prolactinoma under DA treatment.Methods: ...

ea0090ep852 | Pituitary and Neuroendocrinology | ECE2023

Three spontaneous pregnancies on active acromegaly, possible event !

Yahi Abdelkader , Lachkhem A , Derradji H , Staifi A , Derriche A , Ould-Kablia S

Pregnancies in women with acromegaly are rare. Data from the literature report the absence of fetal malformation, a rarely symptomatic increase in adenomatous volume, a possible risk of gestational diabetes and gravidic hypertension in women not controlled before pregnancy. We report the case of a 32-year-old woman, nulliparous, who consults for spaniomenorrhea associated with chronic headaches, in whom the diagnosis of acromegaly was suspected in the face of a very discreet a...

ea0090ep853 | Pituitary and Neuroendocrinology | ECE2023

Aggressive Cushing’s: A Rare Case of Pancreatic ACTHoma in a Young Female

Paulo Reyes Oscar , Denise Sison Ana , Colleen Dimayuga Diana , Villa Michael

Introduction: Adrenocorticotropic hormone-producing pancreatic neuroendocrine neoplasm is a rare type of pancreatic neuroendocrine tumor that causes ectopic adrenocorticotropic hormone syndrome. Cushingoid manifestations and metabolic abnormalities can occur rapidly. High index of suspicion is required for early diagnosis. Case: A 31-year-old Filipino female presented with facial and ankle swelling that occurred 6 weeks before the visit. She also had acn...

ea0090ep855 | Pituitary and Neuroendocrinology | ECE2023

Risk of neoplasms in acromegaly : a monocentric retrospective study

Haj Kacem Akid Faten , Belabed Wafa , Mouhaymen Missaoui Abdel , Charfi Nadia , Mejdoub Nabila , Ben Salah Dhoha , Abid Mohamed

Background and aim: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth, cardiometabolic disturbances and an increased neoplastic risk. This study aims to assess the tumorigenic potential of GH excessive secretion.Patients and Methods: We conducted a retrospective study (1997-2020) at the Endocrinology department of Hedi Chaker...

ea0090ep856 | Pituitary and Neuroendocrinology | ECE2023

Carcinoid Syndrome With Mesenteric Ischemia

Alkan Ozlem , Koksalan Damla , Selek Alev , Canturk Zeynep , Cetinarslan Berrin

Introduction: Carcinoid tumors are included in the neuroendocrine tumor family. They are usually seen in the gastrointestinal tract and are asymptomatic unless liver metastases are present.Case Report: A 44-year-old male patient was admitted with chronic crampy abdominal pain, diarrhea, and redness of the face and neck. He was admitted to the emergency department for abdominal pain many times before and was hospitalized in the general surgery department ...

ea0090ep857 | Pituitary and Neuroendocrinology | ECE2023

Controlling intracellular cortisol: Can HSD-1 inhibition reduce Cushing’s syndrome morbidity and minimize adrenal insufficiency risk?

Czerwiec Frank , Katz David A. , M Stewart Paul

Endocrinologists focus on circulating and excreted cortisol for diagnosis of, and to assess severity and treatment response in, Cushing’s syndrome (Cs). However, in Cs, morbidity is mediated by excess cortisol binding to intracellular glucocorticoid (GC), mineralocorticoid (MC), and non-genomic receptors. We and others have demonstrated that 11b-hydroxysteroid dehydrogenase type 1 (HSD-1) is the source of about half of intrahepatocellular cortisol in healthy adults, patie...

ea0090ep858 | Pituitary and Neuroendocrinology | ECE2023

Dual Endocrinopathy – a Case Vignette

Huang Wenhui

Initial Presentation (February 2018) A 54 years old Chinese male attended the Emergency Department of a public hospital in February 2018 for psychotic symptoms of 1-month duration. He has a past medical history of bifrontal craniotomy 20 years ago for brain tumour. A computed tomography scan of the head was performed which showed increased pituitary fossa and suprasellar space soft tissue. A pituitary hormone panel was performed [Table 1]. He was diagno...

ea0090ep859 | Pituitary and Neuroendocrinology | ECE2023

The efficiency of treatment with growth hormone replacement therapy in children with idiopathic growth hormone deficiency in Albania

Shkurti Adela

Background: The idiopathic growth hormone (GH) deficiency is defined as the shortest height (-2 SD) without any further pathologies, including a detailed hormonal and radiological evaluation.Objective and hypotheses: The evaluation of the efficiency of treatment with somatropin in children with idiopathic gh deficiency in Albania.Methods: The study is based on the survey of 50 children of different ages, diagnosed with idiopathic G...

ea0090ep860 | Pituitary and Neuroendocrinology | ECE2023

GH deficiency caused by a macroprolactinoma: difficulty of management

Dorraelguiche Dorra , Najla Bchir , Ben Chehida Annaam , Myriam Baltagi , Chadia Zouaoui , Ouertani Haroun

Introduction: The use of GH treatment in patients with macroadenomas and GH deficiency is of concern to the clinician due to the theoretical stimulation of tumor regrowth by GH substitution. We report the case of an 18-year-old adolescent with a macroprolactinoma causing delayed stature and puberty.Observation : We report the case of an 18-year-oldadolescent who consulted for gynecomastia with delayed stature and puberty. Physical examination displayed a...

ea0090ep861 | Pituitary and Neuroendocrinology | ECE2023

A Case of Acute Psychosis Triggered by Anabolic Steroid Abuse

Bey Cyrine , Abdelghaffar Wafa , Taieb Ach , Haloui Nadia , Ines Bouzid Mariem , Rafrafi Rym

Introduction: Professional athletes commonly use anabolic-androgenic steroids (AAS) to enhance performance. AAS include testosterone and its numerous synthetic analogs. AAS have numerous adverse effects among which central nervous system effects that include psychosis, delirium, mania and depression. Trenbolone is an AAS medication which is used in veterinary medicine for cattle muscle growth. What makes Trenbolone interesting is that it’s also capable of inducing Selecti...

ea0090ep862 | Pituitary and Neuroendocrinology | ECE2023

A polyuro polydipsic syndrome revealing a somatotropic adenoma in apoplexy: a case report

Halouache Ali , Zouna Caimae , Jad Isouani , Ahmed Anas Guerboub

Introduction: Pituitary apoplexy is an acute infarction and/or hemorrhage of the normal or tumoral pituitary gland. It is a rare mode of revelation of pituitary adenomas, and the only situation where the pituitary adenoma can be complicated by a diabetes insipidus. Case report: Mrs Amina. Y, 54 years old, has been followed for 8 years for diabetes mellitus treated with metformin, and dyslipidemia under statins, presents in consultation for a severe polyu...

ea0090ep863 | Pituitary and Neuroendocrinology | ECE2023

Prolactinoma and Pregnancy

Leila Belhadi , Salma Bensbaa , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Prolactin adenomas are the most common pituitary adenomas. Although the pituitary increases in size and the prolactinoma increase gradually during normal pregnancy; prolactinomas do not contraindicate pregnancy but require strict monitoring.Goals: To study the impact of pregnancy on the development of prolactin pituitary adenomas.Materials and methods: Retrospective descriptive cohort study conducted in the endocrinol...

ea0090ep864 | Pituitary and Neuroendocrinology | ECE2023

Pituitary apoplexy and prolactinomas. About a case series

Logwin Sergio , Romero Fabiola , Canata Gabriela , Lis Alarcon Bernal Maria , Ferreira Dahiana

Introduction: Pituitary apoplexy describes the ischemic or hemorrhagic phenomenon that occurs in a previous pituitary adenoma. It may be the first manifestation of a pituitary gland adenoma.Case 1: Female 31 years old macroprolactinoma in irregular treatment with cabergoline for three months Amenorrhea from the age of 14. Decreased visual acuity and oppressive headache. MRI pituitary apoplexy. Hospitalized and discharged with cabergoline and prednisone. ...

ea0090ep865 | Pituitary and Neuroendocrinology | ECE2023

Asprosin, a novel adipokine, in the mouse hypothalamus: expression and in vitro effect on GT1-7 cells proliferation and GnRH secretion. Preliminary data

Wachowska Dominika , Respekta Natalia , Kurowska Patrycja , Błasiak Anna , Dupont Joelle , Rak Agnieszka

Introduction: Asprosin, a novel adipokine, is a circulating hormone mainly secreted by white adipose tissue. Asprosin is encoded by the penultimate 2 exons of the fibrillin 1 (FBN1) gene. Protein product of FBN1 is profibrillin-1, which undergoes a proteolytic cleavage by furin enzyme to produce mature fibrillin-1 and asprosin. Literature data indicated that asprosin is involved in the development of diabetes, obesity, cardiomyopathy, cancer, and polycystic o...

ea0090ep866 | Pituitary and Neuroendocrinology | ECE2023

Immunotherapy-induced Endocrinopathy: A Case Report

Ali Khaoula Ben , Fatma Loukil , Pauline Busieau , Louis Potier , Camoin Marion , Bouaziz Hanen , Al Mukh Hasanain , Carlier Aurelie , Francois Gautier Jean

Introduction: Immunotherapy is an effective therapeutic choice increasingly prescribed in oncology. Endocrine toxicity is described among its side effects.Methods: A case of a patient treated with immunotherapy since January 2022 is hospitalized in the endocrinology department in Bichat Hospital.Results: Mr K, aged 46, treated with of anti-CTA4 and anti-PD1 inhibitors for melanoma. A month after the treatment the findings showed an...

ea0090ep867 | Pituitary and Neuroendocrinology | ECE2023

Null cell adenoma: case report

Lachkhem Aicha , Yahi Abdelkader , Kablia Samia Ould , Derriche Abderrahim , Staifi Ahcen , Derradji Hakim

Introduction: Pituitary adenomas, more recently referred to as pituitary neuroendocrine tumors (PitNets) from other organs, are common neoplasms comprising 10 to 20% on intracranial tumors. Null cell adenoma is a diagnosis of exclusion that requires immunonegativity for all adenohypophyseal hormones and a lack of cell type-specific transcription factors. It represents 0,6% of all pituitary tumors. Case: A 55 years old women with a history of treated thyr...

ea0090ep868 | Pituitary and Neuroendocrinology | ECE2023

Co-secreting TSH and GH pituitary adenoma

Besrour Chayma , Chiboub Marwa , Salem Maram Ben , Adel Meriem , Jemel Manel , Kandara Hajer , Kammoun Ines

Introduction: Thyrotropin-secreting pituitary tumors (TSH-omas) are a rare cause of hyperthyroidism and account for 0.5 to 3 percent of all functioning pituitary tumors and much less than 1 percent of all cases of hyperthyroidism. The co-secretion of thyrotropin (TSH) and growth hormone (GH) in pituitary adenoma is extremely rare. Only a few cases have been reported.Observation: We report the case of a 40-year-old man who consulted an ophthalmologist for...

ea0090ep869 | Pituitary and Neuroendocrinology | ECE2023

Evolutionary and hormonal aspects after transphenoidal surgery for cushing’s disease

Asma Gorchene , Ach Taieb , Ben Hadj Slama Nassim , Saad Ghada , Abdelkarim Asma Ben , Chadli Chaieb Molka

Introduction: Cushing’s disease (CD), a hypercorticism caused by an ACTH-secreting pituitary adenoma, was associated with a 5-year survival of only 50%. Although advances in management have significantly reduced mortality, the results of transsphenoidal surgery, the gold standard in the treatment of CD, vary from patient to patient.Objective: The aim of our study is to evaluate the results of transsphenoidal surgery in CD (evolution, complications) ...

ea0090ep870 | Pituitary and Neuroendocrinology | ECE2023

A chordoma of the sphenoidal region: diagnostic challenge

Boubagura Imane , El Mghari Ghizlane , El Ansari Nawal

Introduction and Backgrounds: Pituitary adenomas emerge from the adenohypophysis and are confined to the region of the sella turcica, however, other sites may be involved as a result of extension infiltration, or ectopic location, the ectopic involvement of the sphenoid is rare. Case Report: Our case illustrated a woman patient with an ectopic invasive macroprolactinoma diagnosed as a chordoma of the skull base. In Our case, the first histological examin...

ea0090ep871 | Pituitary and Neuroendocrinology | ECE2023

Reset Osmostat Syndrome: When Hyponatremia Become «A Normal». Diagnostics, Case Report

Astafyeva Ludmila , Badmaeva Inna , Klochkova Irina , Sharipov Oleg , Sidneva Yuliya , Gadjieva Olga , Bashiryan Boris , Kalinin Pavel , Lubnin Andrei , Konovalov Aleksandr

Reset osmostat syndrome (ROS) is characterized by a change of normal plasma osmolality level (decrease or increase), which leads to chronic dysnatremia (hypo- or hypernatremia). We have described a Clinical case of ROS and chronic hyponatremia in a patient with chordoid glioma of the III ventricle. It is known that the patient had previously been diagnosed with hyponatremia (131-134 mmol/l). She has not hypothyroidism and hypocorticism. There is normal filtration function of t...

ea0090ep872 | Pituitary and Neuroendocrinology | ECE2023

Central diabetes insipidus in adolescents : Not always a craniopharyngioma

Zeryouh Nabila , Laalaoua Yousra , Chaymae Hamdane , Najoua Messaoudi , Rouf Siham , Latrech Hanane

Introduction: Central diabetes insipidus reflects a serious underlying pathology in children. The etiologies are dominated in pediatric population by: central nervous system (CNS) tumors and malformations, histiocytosis, postoperative, radiation, and trauma injury to the hypothalamic-pituitary region. We report in this work three observations illustrating rare etiologies of pediatric central diabetes insipidus in the endocrinology-diabetology and nutrition department of the Mo...

ea0090ep873 | Pituitary and Neuroendocrinology | ECE2023

Diabetes Insipidus caused by autoimmune lymphocytic hypophysitis resulting in diagnosis and cure of Diffuse Large B-Cell Lymphoma

Sinclair Lydia , Sahota Shaan , Chawda Sanjiv , Heath Maureen , Dulley Louise , Pollock Jonathan , Clough Victoria , Stojanovic Nemanja

Introduction: Association between lymphoma and pituitary dysfunction is well documented, though most commonly through mechanism of infiltrative pituitary metastasis, or primary lymphoma of the pituitary, rather than autoimmune lymphocytic hypophysitis. Here we present a highly unusual case whereby investigation into the cause of Diabetes Insipidus with radiological features of lymphocytic hypophysitis, led to diagnosis and cure of Diffuse Large B-cell lymphoma (DLBCL). Diabete...

ea0090ep874 | Pituitary and Neuroendocrinology | ECE2023

Clinical and biological peculiarities of non-functioning pituitary adenomas in the Tunisian population: a monocentric study

Mouhaymen Missaoui Abdel , Rekik Majdoub Nabila , Soomauroo Siddiqa , Haj Kacem Akid Faten , Ben Salah Dhoha , Mnif Fatma , Charfi Nadia , Mnif Mouna , Elleuch Mouna , Abid Mohamed

Background and Aim: Non-functioning pituitary adenoma (NFPA) is the second most common subtype of pituitary adenomas. This study aims to detail the clinical and biological particularities of NFPA in the Tunisian population.Patients and Methods: A retrospective descriptive study of 35 patients followed for NFPA was conducted between 2000 and 2022 at the endocrinology Department of Hedi Chaker University Hospital, Sfax, Tunisia.Resul...

ea0090ep875 | Pituitary and Neuroendocrinology | ECE2023

Prevalence and factors associated with pituitary apoplexy in non-functioning adenomas

Mouhaymen Missaoui Abdel , Rekik Majdoub Nabila , Soomauroo Siddiqa , Haj Kacem Akid Faten , Ben Salah Dhoha , Mnif Fatma , Charfi Nadia , Mnif Mouna , Elleuch Mouna , Abid Mohamed

Objective: To determine the prevalence and the associated factors of pituitary apoplexy (PA) in non-functional pituitary adenomas (NFPA). Patients and Methods: A retrospective analytical study of 35 patients followed for NFPA between 2000 and 2022 was conducted at our institution. A pituitary magnetic resonance imaging (MRI) scan was performed in all patients.Results: The mean age was 52.1&pm;11.4 years, with a male predominance (6...

ea0090ep876 | Pituitary and Neuroendocrinology | ECE2023

Non-functional pituitary adenomas: management and therapeutic outcomes in the Tunisian population

Mouhaymen Missaoui Abdel , Rekik Majdoub Nabila , Soomauroo Siddiqa , Haj Kacem Akid Faten , Ben Salah Dhoha , Mnif Fatma , Charfi Nadia , Mnif Mouna , Elleuch Mouna , Abid Mohamed

Objective: To assess the management and therapeutic outcomes of non-functioning pituitary adenomas (NFPA) in the Tunisian population.Patients and Methods: We conducted a retrospective descriptive study of 35 patients followed for NFPA between 2000 and 2022 at the endocrinology department of Hedi Chaker University Hospital.Results: The mean age was 52.1&pm;11.4 years, with a male predominance (61.3%). The majority of tumors were bet...

ea0090ep877 | Pituitary and Neuroendocrinology | ECE2023

Growth hormone deficiency in pseudohypoparathyroidism type 1a: a case report

Haj Kacem Akid Faten , Belabed Wafa , Mouhaymen Missaoui Abdel , Safi Wajdi , Elleuch Mouna , Charfi Nadia , Mnif Fatma , Mejdoub Nabila , Mnif Mouna , Abid Mohamed

Introduction: Pseudohypoparathyroidism (PHP) type 1a is a genetic disorder associated primarily with resistance to parathyroid hormone (PTH). Its pathogenesis has been linked to dysfunctional G-protein-mediated signaling. Since the G unit is an ubiquitary protein, its mutation can lead to variable hormonal dysfunction. In this context we report the case of a patient followed in our department for multihormone resistance.Case report: A 9 years old boy, bo...

ea0090ep878 | Pituitary and Neuroendocrinology | ECE2023

Clinico-biological profile of hypopituitarism associated with somatotropic adenomas

Haj Kacem Akid Faten , Belabed Wafa , Mouhaymen Missaoui Abdel , Elleuch Mouna , Mnif Fatma , Ben Salah Dhoha , Mejdoub Nabila , Mnif Mouna , Abid Mohamed

Background and aim: Acromegaly is mostly due to a somatotropic adenoma. Regarding its insidious nature, this adenoma is often revealed at an invasive stage when one or more hormonal insufficiencies are already installed. This study aims to describe the clinical and biological features of hypopituitarism associated with somatotropic adenomas.Patients and Methods : We conducted a retrospective study at the Endocrinology department of Hedi Chaker University...

ea0090ep879 | Pituitary and Neuroendocrinology | ECE2023

Pituitary Tumours and Learning Difficulties-An Association or Incidental Finding?

Bashir Mahamud , Etbinah Lubna , Oyesanya Ayodeji , Ramachandran Kirtanya , Mohammed Mohammed , Karaca Anara , Mlawa Gideon

Introduction: Pituitary tumours one of the most commonly occurring intracranial neoplasms accounting for up to the 15 % of all intracranial neoplasms. Pituitary tumours are often associated with overproduction of hormones or, when they are large, they cause mass effect on surrounding neural structures which are adjacent to their typical location in the Sella turcica. Due to their multifaceted effects pituitary tumours may cause cognitive impairment due hormonal deficiency or m...

ea0090ep880 | Pituitary and Neuroendocrinology | ECE2023

What About Neuro-Endocrine Recovery After Pituitary Apoplexy?

Sara Chtioui , Meryam Alhyane , Rafi Sana , Mghari Tabib Ghizlane El , Ansari Nawal El

Introduction: Pituitary apoplexy is a serious medical complication of a pre-existing pituitary adenoma characterized by a variety of clinical symptoms ranging from mild headache to neurologically impaired and finally comatose patients.Case report : We report a case of apoplexy in a large prolactinoma resulting in empty sella syndrome with a successful pregnancy. Our patient is a 31-year-old female, with a history of macroprolactinoma for approximately 7y...

ea0090ep881 | Pituitary and Neuroendocrinology | ECE2023

Neuroendocrine neoplasms of the larynx: A small case series

Jihene Houas , Jawaher Kechiche , Monia Ghammam , Arfi Taissir Ben , Omri Malika El , Mouna Bellakhdher , El Abed Yosra Hasni , Abir Meherzi , Wassim Kermani , Mohamed Abdelkefi

Introduction: Laryngeal neuroendocrine neoplasms are very rare malignancies comprising less than 1% of all laryngeal neoplasms.Methods: Retrospective study including 5 cases of pharyngolaryngeal neuroendocrine tumors.Results: The average age was 49 years ranging from 35 to63 years with a sex ratio of 4. The average consultation delay was 8 monthes. All patients patients were tobacco users. the chief complaint was dysphonia and dysp...

ea0090ep882 | Pituitary and Neuroendocrinology | ECE2023

Clinical case of partially resistant prolactinoma

Ukhanova Yulia , Ilovayskaya Irena

In real practice, pituitary adenomas may have non-specific clinical manifestations. Patients are consulted by doctors of various specialties, but not endocrinologists. In confirmation of this we would like to present a Clinical case Male patient D. experienced severe headache at the age 39 y.o., was consulted by the neurologist. MRI demonstrated a pituitary macroadenoma 35x36x36 mm in size (22680 mm3) with supra-para-infrasellar growth. The neurosurgeon recommended surgical tr...

ea0090ep883 | Pituitary and Neuroendocrinology | ECE2023

Growth hormone deficiency and celiac disease: an association not to be missed

Gorgi Khaoula , Echchad Lamya , Guissi Loubna , Rifai Kaoutar , Iraqi Hinde , El Hassan Gharbi Mohamed

Introduction: Celiac disease (CD) is an autoimmune enteropathy, induced by dietary gluten in genetically predisposed subjects, which manifests itself, most often, by digestive signs but also extra-digestive signs, in particular failure to thrive (FTT), nevertheless it is necessary to remain vigilant with regard to a real associated somatotropic deficit.CASE: A 14-years-old male patient, followed for a celiac disease since the age of 6 years, under a stri...

ea0090ep884 | Pituitary and Neuroendocrinology | ECE2023

Hypoplasia of the corpus callosum revealed by staturoponderal growth retardation: about a clinical observation

Boubagura Imane , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: The corpus callosum is the most important of the interhemispheric commissures, its fibers called callosal radiations have a transverse direction. They connect different points of the neocortex. The corpus callosum represents the neopallial commissure; it has indeed a phylogenetic development modeled on that of the neocortex. Hypoplasia of the corpus callosum is included in a rare polymalformative syndrome characterized by agenesis of the corpus callosum (CC), dis...

ea0090ep885 | Pituitary and Neuroendocrinology | ECE2023

Crooke’s Cell Adenoma:Aggressive Corticotroph Adenoma

Ni Aung Nwe , Azad Fatima , Butt Nouman

Introduction: Crooke’s cell adenomas are nonneoplastic corticotropes with cytoplasmic accumulation of cytokeratin filaments in response to glucocorticoid excess. They are rare subtype of corticotrope adenomas presenting less than 1 % of pituitary adenomas.Case: 52 years old man attended Ophthalmology Clinic with 2 months history of right-sided reduced vision. He had a history of posterior polymorphous corneal dystrophy with a left corneal transplant...

ea0090ep886 | Pituitary and Neuroendocrinology | ECE2023

Acromegaly may be associated with gynaecological and skin forms of cancer

Ioana Iulia Greere Daniela , Baciu Ionela , Capatina Cristina , Poiana Catalina

Introduction: Acromegaly is a rare disease usually caused by growth hormone (GH) secreting pituitary adenomas (PA) and associated with a series of complications, including tumours. The most prevalent tumour types are colonic adenomas, colorectal cancer (1) and nodular goiter (2). We present two acromegaly cases attending our center that associate cervical cancer and another that associates melanoma. Clinical cases: Case 1: A 56-yea...

ea0090ep887 | Pituitary and Neuroendocrinology | ECE2023

Non-secreting pituitary adenomas: clinical, biological, radiological and therapeutic aspects: a review of 17 cases

Rekaya Zeineb , Bchir Najla , Ben Zaied Fatma , Ben Chehida Anaam , Chadia Zouaoui , Ouertani Haroun

Non-secreting pituitary adenomas (NSPA) are relatively rare benign tumors their prognosis depends essentially on their endocrine and ophthalmological repercussions the aim of our study is to outline their clinical, biological, radiological aspects, and the therapeutic choice.Methods: Retrospective study of 17 patients with non secreting pituitary adenomas.Results: We identified 17 patients with NSPA split into 12 women and 5 men wi...

ea0090ep888 | Pituitary and Neuroendocrinology | ECE2023

Lymphocytic hypophysitis simulating a pituitary adenoma

Boubagura Imane , Midhat Ilham , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Lymphocytic hypophysitis is a rare inflammatory disease of the pituitary gland of autoimmune origin, related to a diffuse infiltration of the pituitary gland sometimes leading to severe hypopituitarism. It is frequent in pregnant or postpartum women.Case report: A 28 year old female patient, followed up for pituitary microadenoma with prolactin for 5 years under dostinex 1 tablet/week who reported headaches with visual acuity decrease with ...

ea0090ep889 | Pituitary and Neuroendocrinology | ECE2023

Disease Control on Lanreotide in a Patient with Acromegaly

Joel Rudy Ekoundzola , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Medical treatment of acromegaly with somatostatin analogues (SAs) has been used for a long time and is a well-established treatment in cases where surgery, which is the first-line treatment, is impossible or inadequate. We report a case of acromegaly under control after initiation of Lanreotide.Observation: Patient aged 59 years, referred for acromegaloid dysmorphic syndrome initially with tumor syndrome with IGF1 workup at 729 ng/mL (norma...

ea0090ep890 | Pituitary and Neuroendocrinology | ECE2023

Case report of a patient with paraganglioma diagnosed after surgery

Cheshlaroska Markushoska Katerina , Milenkovic Tatjana , Cheshlaroska Hristina , Bilaloglu Jovanoska Belma , Tafa Arta

Introduction: Paraganglioma is a tumour derived from extra-adrenal chromaffin cells of the sympathetic paravertebral ganglia of the thorax, abdomen and pelvis. About 36 % to 60 % of the paragangliomas are functional secreting norepinephrine and normetanephrine, which cause hypertension. Non-functional paragangliomas can produce Chromogranin A. Paragangliomas also arise from the parasympathetic ganglia located along the glossopharyngeal and vagal nerves in the neck and at the b...

ea0090ep891 | Pituitary and Neuroendocrinology | ECE2023

Suprasellar Germinoma with Hypopituitarism and Central Diabetes Insipidus

Kanburoglu Meletli Ozlem , Birinci Cigdem , Cuneyt Bilginer M. , Coskun Hulya , Nuhoglu Irfan , Ucuncu Ozge , Kocak Mustafa

Introduction: Germinomas, which are the most common germ cell tumors of the central nervous system, may present with different symptoms depending on the location and are localized in the 20-30% suprasellar region. Here, we aimed to present a case of suprasellar germinoma with central diabetes insipidus, hypogonadism and secondary adrenal insufficiency.Case Report: A 27-year-old male patient presented with dry mouth, polydipsia, polyuria and nocturia for ...

ea0090ep892 | Pituitary and Neuroendocrinology | ECE2023

A diagnostic dilemma

Shoaib Zaidi Muhammad

Introduction: Nasopharyngeal carcinoma is a rare entity with a predominant geographic distribution in North Africa, Arctic, Southern China and Southeast Asia. Case Presentation: 32 yrs old, single, Saudi, male, had presented to our hospital on 26.11.2022. He had 2 months history of undocumented fever, blackish oral lesions, anorexia and profound weight loss(20kgs). He had become fully dependent and bed-bound. No addictions, allergies or high risk behavio...

ea0090ep893 | Pituitary and Neuroendocrinology | ECE2023

A case of ectopic ACTH syndrome in squamous cell lung cancer

Sebile Dokmetaş Hatice , Akkoyun Ayşenur , Eren Esma , Şahin Onur , Dokmetaş Meric , zeynep Ağaoğlu Hikmet , Kaan Turk Oğuz

Cushing’s syndrome as a result of ectopic adrenocorticotropic hormone (ACTH) secretion, is associated with various tumors. Lung squamous cell carcinoma (LUSC) causing ectopic ACTH syndrome is a very rare condition. A 70-year-old male patient with a history of LUSC was admitted to our clinic for evaluation of worsening delirium and hypokalemia. Two courses of pembrolizumab were administered to our patient who was diagnosed with LUSC a month ago. At presentation, neurologic...

ea0090ep894 | Pituitary and Neuroendocrinology | ECE2023

Clinical features and outcomes of an FSH-secreting pituitary adenoma: a case report

Mouhaymen Missaoui Abdel , Rekik Majdoub Nabila , Soomauroo Siddiqa , Haj Kacem Akid Faten , Elleuch Mouna , Mnif Fatma , Charfi Nadia , Mnif Mouna , Ben Salah Dhoha , Abid Mohamed

Introduction: Pituitary adenomas are the most frequent sellar tumors in adults. Depending on their hormonal profile in vivo and on immunohistochemistry, they present different clinical profiles and progression outcomes. Thus, we report a case of an FSH-secreting pituitary adenoma.Observation: The patient SG is 63 years old. He complained of intermittent headaches associated with a progressive decrease in visual acuity. Ophthalmological examinati...

ea0090ep895 | Pituitary and Neuroendocrinology | ECE2023

Osteoporosis as a complication of acromegaly

Antanavičiūtė Kamilė , Žilaitienė Birutė

Context: Acromegaly is associated with many complications, which affects multiple systems, such as cardiovascular, respiratory, metabolic, muscles and bones. Osteoporosis and osteoporosis fracture are commonly neglected comorbidity of this rare disease. Usual manifestation of this skeletal complication is skeletal fragility and vertebral fractures, but prior research confirms, that other location fractures can be found as well. Case illustration: We repo...

ea0090ep896 | Pituitary and Neuroendocrinology | ECE2023

Polyuria-polydipsia syndrome : diagnosis approach through a case report

Ait Si Ali Zineb , Oussama Jaddi , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Polyuro-polydipsia syndrome (PPS) is defined by urine excretion rate more than 3L per day, associated with a parallel increase in oral fluid intake. It poses problems of positive and etiological diagnosis. We discuss in this observation the modalities of exploration of PPS and its main etiologies.Case report: A 60-year-old patient, diabetic for 10 years, controlled on metformin, admitted for PPS evolving for 37 years. Clinical examination w...

ea0090ep897 | Pituitary and Neuroendocrinology | ECE2023

Different etiologies of the endocrine hyponatremia

Margvelashvili Natia , Shonia Natia , Zavrashvili Nino , Chanturishvili Ketevan , Gvazava Qetevan , Arjevanidze George

Hyponatremia is the most common disorder of electrolytes encountered in clinical practice, occurring in 15-30% of acutely or chronically hospitalized patients. Although many cases are mild and relatively asymptomatic, hyponatremia is nonetheless important clinically because: acute severe hyponatremia can cause substantial morbidity and mortality; overly rapid correction of chronic hyponatremia can cause severe neurological deficits and death. We present Clinical cases of endoc...

ea0090ep898 | Pituitary and Neuroendocrinology | ECE2023

Acromegaly: Clinico-biological and radiological features

Faten Cherchir , Mekni Sabrine , Essayeh Sawsen , Abidi Sahar , Mchirgui Nadia , Rojbi Imen , Ben Nacef Ibtissem , Khiari Karima

Introduction: Acromegaly results from an autonomous hypersecretion of growth hormone (GH) typically by a pituitary adenoma, commonly revealed by a dysmorphic syndrome. The aim of our study was to describe clinico-biological and radiological features of acromegaly.Methods: We conducted a retrospective study including 28 patients with acromegaly followed in the endocrinology department of Charles Nicolle Hospital. Clinical, biochemical, ophthalmological an...

ea0090ep899 | Pituitary and Neuroendocrinology | ECE2023

Ophthalmological complications in acromegaly

Haj Kacem Akid Faten , Belabed Wafa , Mouhaymen Missaoui Abdel , Elleuch Mouna , Mnif Fatma , Mejdoub Nabila , Abid Mohamed

Background and aim: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and cardiometabolic disturbances. This study aims to describe the ophthalmologic complications seen in acromegaly.Patients and Methods : We conducted a retrospective study (1997-2020) at the Endocrinology department of Hedi Chaker University Hospital, Sfax,...

ea0090ep900 | Pituitary and Neuroendocrinology | ECE2023

Pituitary Macroadenoma and hypercalcaemia - An association or an incidental finding?

Hayat Maisha , English Robert , Ahuja Sanjali , Lowe Miriam , Khan Alaina , Mahamud Bashir , Nozdrin Mikhail , Mlawa Gideon

Introduction: Multiple Endocrine Neoplasms (MEN) are a group of rare hereditary tumours which have strong predisposition to endocrine organs. MEN1 is an autosomal-dominant inherited neoplasm with a broad genetic phenotype, characterised by synchronised or asynchronous triad neoplasms localised in the anterior pituitary, parathyroid and pancreas (Kamilaris and Stratakis, 2019; Li et al., 2022). Despite advances in the fields of diagnostic techniques and therapies, MEN1...

ea0090ep901 | Pituitary and Neuroendocrinology | ECE2023

Obesity prevalence in patients with acromegaly

Haj Kacem Akid Faten , Belabed Wafa , Mouhaymen Missaoui Abdel , Elleuch Mouna , Mejdoub Nabila , Ben Salah Dhoha , Abid Mohamed

Background and aim: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and cardiometabolic disturbances. This study aims to determine the prevalence of obesity in patients with acromegalyPatients and Methods : We conducted a retrospective study (1997-2020) at the Endocrinology department of Hedi Chaker University Hospital, Sfa...

ea0090ep902 | Pituitary and Neuroendocrinology | ECE2023

Hyperparathyroidism and Prolactinoma: MEN1 or incidental association?

Maryame Benlafqih , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Primary hyperparathyroidism and prolactinoma can be associated as part of a MEN1. However, the association of the two pathologies can also be seen outside of a syndrome predisposing to endocrine tumors. Case presentation: F.L., a 33-year-old woman followed for end-stage renal failure, during her follow-up hyperparathyroidism was discovered without any idea of the culprit and the victim: is the renal failure secondary to hyperparathyroidism ...