ECE2023 Eposter Presentations Pituitary and Neuroendocrinology (234 abstracts)
Neuroendocrine neoplasms of the larynx: A small case series
Houas Jihene 1 , Kechiche Jawaher 1 , Ghammam Monia 1 , Ben Arfi Taissir 1 , El Omri Malika 1 , Bellakhdher Mouna 1 , Hasni El Abed Yosra 2 , Meherzi Abir 1 , Kermani Wassim 1 & Abdelkefi Mohamed 1
1ENT Department and Neck Surgery of Farhat Hached Hospital, Sousse, Tunisia; 2Endocrinology Department Farhat Hached Hospital, Sousse, Tunisia
Introduction: Laryngeal neuroendocrine neoplasms are very rare malignancies comprising less than 1% of all laryngeal neoplasms.
Methods: Retrospective study including 5 cases of pharyngolaryngeal neuroendocrine tumors.
Results: The average age was 49 years ranging from 35 to63 years with a sex ratio of 4. The average consultation delay was 8 monthes. All patients patients were tobacco users. the chief complaint was dysphonia and dyspnea. Indirect laryngoscopy objectified a tumoral lesion arising from the left aryepiglottic region in one case, a tumoral lesion taking the 3 levels of the larynx with a fixed hemilarynx in 3 cases. One patient already had known lymph node involvement upon presentation. The staging assessment did not show distant metastases in all cases. The anatomopathological study of the biopsies with immunohistochemical analysis was in favor of a well-differentiated carcinoid tumor in 1 case, of small cell neuroendocrine tumor in 3 cases and of a poorly differentiated high-grade neuroendocrine in 1 case. Therapeutic management consisted of radio-chemotherapy in 2 cases, total laryngectomy in 2 cases and total pharyngolaryngectomy in 1 case. One patient developed locoregional recurrence and 2 distant metastases.
Conclusion: Laryngeal neuroendocrine tumors are extremely rare and heterogenous malignancies. It requires aggressive treatment and active follow-up.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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