Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 90 | ECE2023 | Next issue

25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

Card image cap
ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

Oral Communications

Oral Communications 7: Pituitary and Neuroendocrinology 2

ea0090oc7.1 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

Investigating intranasal kisspeptin as a novel, effective and preferable route of delivery using human, rodent and pharmaceutical models

Mills Edouard G , Swedrowska Magda , Delli Virginia , Chachlaki Konstantina , Sergio Mauro , Decoster Laurine , Ternier Gaetan , Thurston Layla , Phylactou Maria , Patel Bijal , Yang Lisa , Clarke Sophie , Muzi Beatrice , Alexander Emma , Choudhury Muhammad , Bech Paul , Abbara Ali , Forbes Ben , Giacobini Paolo , Prevot Vincent , Comninos Alexander , Dhillo Waljit

Background: Kisspeptin is a critical activator of hypothalamic GnRH neurons and is essential for reproductive health. Emerging data reveals that kisspeptin-based therapeutics have substantial potential to treat reproductive, psychosexual and bone disorders. However, current delivery is limited to the subcutaneous or intravenous routes, presenting barriers to development. Alternative routes of administration would overcome this and capitalise on the benefits of kisspeptin-based...

ea0090oc7.2 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

BRF1-Mediated Paracrine Signalling by a Subset of SOX2-Expressing Stem Cells is required for Normal Development of the Stem Cell Compartment and Terminal Differentiation of Pituitary Committed Progenitors

Martinez-Barbera Juan Pedro , Manshaei Saba , Willis Thea , Reen Virinder , Pallikonda Hussayn , Withers Dominic , Gil Jesus , Andoniadou Cynthia

Introduction: Hormone-producing pituitary cell lineages derive from SOX2+ embryonic precursors. These cells maintain multipotency into early postnatal life, acting as the resident population of pituitary stem cells (PSCs) and contributing extensively to all the endocrine cell lineages. Additionally, paracrine signalling from PSCs is important for cell proliferation of neighbouring progenitors (PMC7803373). It is not known if SOX2+ PSCs are involved in the regulation of additio...

ea0090oc7.3 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

The mesenchymal stem cells induce immunosuppressive microenvironment in pituitary tumors

Marrero-Rodriguez Daniel , Taniguchi Keiko , A Cortes-Morales Victor , Valenzuela-Perez Alejandra , Vela-Patino Sandra , Cano-Zaragoza Amayrani , Martinez Florencia , Kerbel Jacobo , Andonegui-Elguera Sergio , Gomez-Apo Erick , Chavez-Macias Laura , Montesinos Juan Jose , Mercado Moises

The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells. MSC are a subset of heterogeneous cell populations characterized by the expression of CD105, CD73, and CD90 that can differentiate into chondrocytes, osteoblasts, and adipocytes in vitro. They are known to have immunomodulatory capabilities. Our aim was to isolate and characterize the immunomodulatory capabilities of MSC from pituitary tumors (P...

ea0090oc7.4 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

Lysine demethylase KDM1A and ectopic expression of GIP-receptor in somatotropinomas of patients with paradoxical response to oral glucose

Chasseloup Fanny , Tosca Lucie , Regazzo Daniela , Proust Alexis , Hage Mirella , Kuhn Emmanuelle , Jublanc Christel , Mokhtari Karima , Salenave Sylvie , Gaillard Stephan , Parker Fabrice , Boch Anne-Laure , Tachdjian Gerard , Chanson Philippe , Bouligand Jerome , Occhi Gianluca , Kamenicky Peter

Introduction: Paradoxical increase of GH following oral glucose load has been described in ~30% of patients with acromegaly and has been related to the ectopic expression of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in somatotropinomas. Recently, we identified germline pathogenic variants of lysine demethylase 1A (KDM1A) in patients with GIP-dependent primary bilateral macronodular adrenal hyperplasia with CushingÂ’s syndrome. Patients...

ea0090oc7.5 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

A novel filamin A-binding molecule may significantly enhance SST2 antitumoral actions in GH-secreting PitNET cells

Marra Giusy , Treppiedi Donatella , Muro Genesio Di , Mangili Federica , Catalano Rosa , Esposito Emanuela , Nozza Emma , Locatelli Marco , Lania Andrea , Sala Elisa , Ferrante Emanuele , Arosio Maura , H. Burns Lindsay , Mantovani Giovanna , Peverelli Erika

The main target of pharmacological therapy for growth hormone (GH)-secreting pituitary tumors (GH-PitNET) is the somatostatin receptor type 2 (SST2). However, approximately half of patients treated with octreotide, an SST2 agonist, show a low response rate or are octreotide-resistant. Here we present mechanistic data that shows co-treatment with simufilam, a novel oral therapeutic candidate, enhances sensitivity to octreotide. We previously showed that the cytoskeleton protein...

ea0090oc7.6 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

Pathophysiological role of splicing machinery in craniopharyngiomas: Novel source of diagnostic, prognostic and therapeutic biomarkers

Flores-Martinez Alvaro , Fuentes-Fayos Antonio C. , G-Garcia Miguel E. , Gonzales David Cano , Caro Isidoro Di , Jesus Martinez-Fuentes Antonio , Castano Justo P. , Gahete Manuel D. , Martinez-Barbera Juan Pedro , Soto-Moreno Alfonso , Angeles Galvez-Moreno Maria , Luque Raul M

Craniopharyngiomas (CPs) are a relatively benign subtype of epithelial tumors that typically originate from the sellar and suprasellar regions of the brain. These endocrine tumors are classified as adamantinomatous (ACP) or papillary (PCP) based on their histological characteristics. Unfortunately, the diagnosis of CPs is frequently made at an advanced stage of tumor development, and therefore relevant associated comorbidities are often present. The first-line treatment is typ...