Endocrine Abstracts

Microplastics are one of the major pollutants over the globe jeopardising the health of aquatic life. The ecotoxicological effects of microplastics are well investigated in marine organisms, however, their impact on freshwater ecosystem remain unnoticed. Gastropod molluscs serve as good bioindicators for environmental toxicology. Therefore, we studied two commonly found freshwater snails, Lymnaea acuminata and Indoplanorbis exustus and checked the effect of m...

There are still many questions remaining about the etiopathogenesis of thyroid cancer, themost common type of endocrine neoplasia. Numerous occupational and environmental exposureshave been shown to represent important risk factors that increase its incidence. Updated informationabout thyroid cancer diagnostics related to occupational and environmental risk factors is reviewedhere, considering an integrated risk assessment approach; new data concerning thyroid canceretiology a...

The ingestion of marine foods is a potential route of contamination by tributyltin (TBT), a biocide organotin used as an antifouling in boat paints. TBT causes a phenomenon known as imposex, that induces, for instance, the irreversible appearance of male sexual characteristics in gastropod females. In mammals, TBT also directly impairs the sexual development. In fact, it is known that TBT can affect women in reproductive age. Our aim was to study whether the maternal exposure ...

The Hypothalamic Pituitary Thyroid (HPT) axis is well-known as a classic endocrine negative feedback loop: increased levels of thyroxine (T4) in the blood are associated with a reduction of thyroid stimulating hormone (TSH) production and vice versa. However, the thyroid hormone (TH) system is sensitive to alterations by a number of endocrine disrupting chemicals (EDCs). Intriguingly, exposure to specific EDCs can decrease the levels of T4 but this might be not followed by the...

Caffeine crosses the placenta and mammary barrier and can affect the offspring metabolism and endocrine system from heavy caffeine users. Here, we tested the impact of a safe dose of maternal caffeine (200-300 mg/day) on plasma hormone of offspring from both sexes at different ages (weaning, puberty and adulthood). For this, pregnant Wistar rats received caffeine (25mg/kg/day) by gavage or vehicle during gestation (GEST group), lactation (LACT group) or both periods (G+L group...