Endocrine Abstracts

Purpose of Study: Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and testosterone replacement therapy (TRT) can increase red blood cell production through different mechanisms. Little is known if combination therapy poses risk of erythrocytosis (ERY) in real world clinical practice.Methods: This was a retrospective nationwide cohort study of US Veterans with type 2 diabetes (T2D) without prior history of ERY who were prescribed SGLT-2i and/or TRT be...

Background: Renal involvement in T2DM can be due to diabetes per se (Diabetic Kidney Disease) or causes other than diabetes (non-diabetic kidney disease). Currently available clinical, biochemical, and radiological markers fail to differentiate DKD from NDKD. Renal biopsy remains gold standard for diagnosis. Urinary signatures may provide a non-invasive alternative to that end. In cell culture and in animal models with diabetes and kidney disease, dysregulation of several meta...

Objective: The aim of this study was to investigate sex-specific associations of two established serum selenium biomarkers, i.e. total selenium and selenoprotein P with type 2 diabetes mellitus (T2D) and hypertension in a large cohort of older people.Methods: 1500 participants with available selenium measurements from the Berlin Aging Study II (BASE-II) were included in this study. In the serum samples, spectroscopy was used to quantify total selenium, a...

Objectives: The angiotensin-converting enzyme (ACE1) gene is one of the most studied genes in the pathogenesis of type II diabetes (T2DM) and cardiovascular disease. However, in the context of exerciSemodels in T2DM, they are not yet fully understood. We intended to characterize the genetic profile of individuals with T2DM from an inter-individual point of view using prognostic markers and cardiovascular risk. On the other hand, relate it with the profile obtained wit...

Introduction: Type 1 diabetes (T1D) is the most frequent children’s endocrinopathy in Portugal. The duration of the disease and metabolic control may affect the final height of pediatric patients. Despite the metabolic advantages of technological advances, such as continuous subcutaneous insulin perfusion (CSII), the effect on growth is unclear.Aim: To assess the impact of T1D treatment, with multiple daily injections (MDI) or CSII, on growth.<p...

Background and objectives: Diabetes is estimated to affect more than half a billion people worldwide, of which approximately 9.5 million live in Turkey. Currently, glucoSemeasurements are made with invasive techniques (eg finger puncture or interstitial glucose sensors) that can negatively affect monitoring. In addition, since glucose results cannot be seen by physicians/nurses in real time, treatment decisions are delayed and diabetes control becomes difficult. As a group of ...