Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2

ea0090rc9.1 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Symptoms of glucocorticoid-induced adrenal insufficiency – A systematic evaluation of clinician- and patient-reported symptoms and their rated relevance

Lund Marie Louise , Bjorner Jakob Bue , Al-Jorani Hajir , Boesen Victor Brun , Dreyer Anja Fenger , Boggild Hansen Simon , Jorgensen Nanna Thurmann , Klose Marianne , Tei Randi , Watt Torquil , Feldt-Rasmussen Ulla , Borresen Stina Willemoes

Context: Glucocorticoid-induced adrenal insufficiency is the most frequent type of adrenal insufficiency, but its symptomatology has not been thoroughly studied.Objective: To describe the predominant symptoms experienced by patients with glucocorticoid-induced adrenal insufficiency and rate these symptoms significance for patients perceived need for supplemental hydrocortisone stress dose.Methods: The 80 symptoms in the...

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ea0090rc9.2 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Frequency of stress dose adjustment and adrenal crisis in children and adults with congenital adrenal hyperplasia

Tschaidse Lea , Wimmer Sophie , Auer Matthias , Lottspeich Christian , F. Nowotny Hanna , Dubinski Ilja , Schmidt Heinrich , Quinkler Marcus , Reisch Nicole

Background: Patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) require lifelong glucocorticoid replacement therapy, including stress dose adjustment to prevent life-threatening adrenal crises (AC). Previous studies indicate a high incidence of inadequate stress dose adjustment and AC in patients with CAH. The aim of this study was to prospectively assess AC incidence, frequency and details of stress dose adjustment as well as knowledge of the d...

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ea0090rc9.3 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Fingerprints of increased susceptibility to adrenal crises in patients with chronic adrenal insufficiency

Chifu Irina , Janik Freytag , Quinkler Marcus , Herterich Sabine , Stephanie Burger-Stritt , Hahner Stefanie

Background: Potentially fatal adrenal crises (AC) still occur in educated patients with adrenal insufficiency (AI). Identifying predisposing factors is necessary for prevention in this patient population.Objectives: Investigating clinical and biochemical fingerprints of increased susceptibility to AC.Material and methods: Our study population included 260 patients with chronic AI, classified as high and low risk according to the fr...

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ea0090rc9.4 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Dysregulations in CLOCK genes in immune cells in congenital adrenal hyperplasia depending on the type of glucocorticoid replacement regimens

Ju Jing , F. Nowotny Hanna , Tschaidse Lea , Auer Matthias , Reisch Nicole

Background: Glucocorticoid (GC) substitution therapy in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is not able to perfectly mimic physiological circadian profiles. Unphysiologically high doses, as well as unphysiological variations in GC concentrations might cause adverSemetabolic, cardiovascular and immunological effects. Previous publications have demonstrated dysregulations in immune cell profiles of patients with primary adrenal ins...

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ea0090rc9.5 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Higher maternal cortisol associated with lower blood pressure in offspring from 3 months to 5 years of age in the odense child cohort

Al-Jorani Hajir , Christian Jensen Richard , Jonasson Mikaela , Birukov Anna , Schmedes Anne Vibeke , Christesen Henrik Thybo , Dreyer Anja Fenger , Jensen Tina Kold , Glintborg Dorte , Jensen Boye Lagerbon , Andersen Marianne

Background: Synthetic glucocorticoid exposure in late pregnancy may be associated with higher blood pressure in offspring. We hypothesized that endogenous cortisol in pregnancy relates to offspring blood pressure (OBP).Objective: To investigate associations between maternal cortisol status in 3rd trimester pregnancy and OBP.Methods: We included 1,317 mother-child pairs from Odense Child Cohort (OCC), an observational prospective co...

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ea0090rc9.6 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Immunohistochemical analysis of somatostatin receptor 2 and the tumor microenvironment in a large set of pheochromocytomas and paragangliomas

Uchihara Masaki , Tanabe Akiyo , Umamoto Kotaro , Maeshima Akiko Miyagi , Kojima Yuki , Sudo Kazuki , Shimoi Tatsunori , Yamazaki Yuto , Sasano Hironobu , Shimomura Akihiko , Shimizu Chikako , Yonemori Kan , Kajio Hiroshi

Introduction: Pheochromocytoma and paraganglioma (PPGL) are rare endocrine tumors with few effective treatment options for malignant cases. Novel therapeutic indications, such as 177Lu-DOTA-TATE and immune checkpoint inhibitors (ICIs) for patients with PPGL, have been investigated in several clinical trials. Emerging evidence shows that somatostatin receptor 2 (SSTR2) in other cancer types correlates with the tumor microenvironment (TME) activation and could be a predictive bi...

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Endocrine Abstracts

25th European Congress of Endocrinology