Endocrine Abstracts

Successful reproduction in humans at a population level, is reliant on the careful co-ordination of reproductive hormones with associated behaviours. Kisspeptin is a neuropeptide that is critical for normal hypothalamic function of the reproductive hormonal axis. However beyond its hormonal effects, non-human data suggests an emerging role for kisspeptin in a range of animal behaviours through extra-hypothalamic downstream neuroendocrine pathways. Until recently, the roles of ...

The proximate cause of functional hypothalamic amenorrhea (FHA) is reversible suppression of GnRH drive that results in chronic anovulation and low estradiol levels that preclude endometrial growth and shedding. Clinical management of FHA requires not only understanding the neuromodulation of GnRH drive, but also how cognitive and behavioral concomitants suppress GnRH drive. FHA results in a constellation of neuroendocrine concomitants that include activation of the hypothalam...

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