Endocrine Abstracts

Aim: To study renal function in patients with severe complications of diabetic foot syndrome (ulcer, gangrene, amputation) associated with chronic kidney disease.

Material and Methods: 91 patients with DM 2 were examined. The patients were divided into 4 groups:1 gr. – 25 patients with DFS complicated by ulcer, gangrene and amputation and in combination with CKD 4-5 stages on hemodialysis; 2 gr. – 25 patients with DFS complicated by ulcer, gangrene and amputation in combination with CKD stages 4-5 without hemodialysis; 3 gr - 20 patients with DFS complicated by gangrene and amputation without CKD.;4 gr - 21 patients with DFS, without severe complications, with the initial stage of CKD.

Research methods: Biochemical (bilirubin, direct, indirect, lipid spectrum, ALT, AST, PTI, coagulogram, blood sugar, glycated hemoglobin, urea, creatinine, GFR, wound pathogens, procalcitonin, interleukin-6, vascular endothelial growth factorVEGF-A and instrumental: ECG, MRI of the feet, Dopplerography of the main vessels of the legs, ultrasound of the internal organs, the fundus.

Results: The highest rates of fasting glycemia were observed in patients of group 2, that is, with DFS and CKD 4-5 stages without hemodialysis. Significantly lower hemoglobin values were also observed in this group of patients (P<0.001), glycated hemoglobin significantly higher values of urea, creatinine and GFR (P<0.001). All patients had significantly reduced values of HDL (P<0.001) and total cholesterol (P<0.05).

Conclusion: Biochemical parameters were significantly impaired in patients of group 1, that is, with DFS and CKD 4-5 stages on hemodialysis, which indicates the need for further research in this group of patients.