Endocrine Abstracts

Introduction: The relationship between indicators of carbohydrate, fat and bone metabolism is beyond doubt. It is known that osteocalcin, overcoming the blood-brain barrier, can affect the development of the fetal brain. Adiponectin is currently being considered as a biomarker for pregnancy complications. These facts determined the purpose of the study.

Aim: To study the content of osteocalcin and adiponectin in pregnant women with type 1 diabetes (T1DM).

Materials and Methods: A prospective single-center study was conducted on the basis of the Republican Scientific and Practical Center "Mother and Child" among pregnant women with a full-term pregnancy. We compared 2 groups of pregnant women: group 1 (Gr 1) - pregnant women with T1DM (n=37) and group 2 (Gr 2) - pregnant women without diabetes (n=31) whose levels of osteocalcin and adiponectin in venous blood were determined the day before delivery. Women of both groups were comparable in terms of pregravid body mass index (BMI) (P=0.263), which was in the normal range (BMI<25) and delivery time. Glycated hemoglobin in pregnant Gr 1 was 6.6% (6.0–7.4%).

Results: The level of osteocalcin in Gr1 was 1.04 (0.58–2.49) ng/ml, and in Gr 2 it was 2.05 (0.87–7.64) ng/ml and was statistically significantly less against the background diabetes (P=0.013). The level of adiponectin in Gr1 was 20.59 (12.4–27.07) mcg/ml, and in Gr2 it was 9.7 (9.04–13.35) mcg/ml and was statistically significantly higher (P<0.001) in pregnant women with type 1 diabetes.

Conclusions: In our study, pregnant women with type 1 diabetes had lower levels of osteocalcin than healthy pregnant women, which can be attributed to the effect of hyperglycemia. Higher levels of adiponectin in pregnant women with type 1 diabetes seem to be associated with autoimmune processes, which requires further study.