Endocrine Abstracts

Aim: To study the parameters of heart Doppler before endovascular revascularization in patients with type 2 diabetes mellitus and without it in patients with coronary artery disease.

Research Material: 60 patients (prospectively) with CHF were examinedafter endovascular revascularizationin the period of 2021 at the Center of Surgery named after acad. V.V. Vakhidov. All observed patients were divided into 2 groups: 1 gr. – 35 patients with DM2 with CHF and undergoing CABG. 2 gr. – 25 patients with CHF without DM2 who underwent CABG. The control group consisted of 20 patients with type 2 diabetes without CHF. To characterize the examined patients were used: general clinical, biochemical and instrumental examinations.

Material and Methods: general clinical, biochemical (bilirubin, direct, indirect, lipid spectrum, ALT, AST, coagulogram, blood sugar, glycated hemoglobin, urea, creatinine, GFR, galectin-3, insulin, renin, aldosterone in the blood) and instrumental: ECG, Echo-ECG, cardiac angiography, Dopplerography of the main vessels of the heart and legs, ultrasound of internal organs, fundus.

Results: We analyzed 60 patients with type 2 diabetes mellitus complicated by coronary artery disease and chronic heart failure. Of these, 19 women, 41 men. Biochemical blood tests showed that the average values of the lipid spectrum were significantly increased in all patients of groups 1 and 2, compared with the control group (P<0.05). The next stage of our research was to study the relationship between various parameters and LV ejection fraction on Echo-ECG by groups. In patients of group 1, Echo-ECG showedrevealed left ventricular dysfunction and cardiomyopathy in 100% of cases, while in patients of group 2 thesechanges were detected in 17% of cases (P<0.05). In patients of group 1, hemodynamic parameters of the heart were significantly lower than in patients of group 2.

Conclusions: It was found that in patients of groups 1 and 2, no significant differences in mean age, BMI, glycemia, renin values, insulin, HOMA index were found depending on the EF values. At the same time, the significance of differences was revealed only for aldosterone and galectin-3; these values significantly increased as EF decreased in patients of group 1. (P<0.05).