ECE2023 Eposter Presentations Adrenal and Cardiovascular Endocrinology (124 abstracts)
Impact of long-term atorvastatin use on renal function in type 2 diabetes patients
Ameni Terzi 1 , Nadia Khessairi 1 , Meriem Yazidi 1 , Ibtissem Oueslati 1 , Hammami Bassem 2 , Fatma Chaker 1 , Feki Moncef 2 & Melika Chihaoui 1
1Rabta, Endocrinology, Tunisia; 2Rabta, Biochemistry, Tunisia
Introduction: Statins are widely used in primary and secondary cardiovascular prevention. They have been described to improve renal function. We aimed in this study to evaluate the effect of high dose atorvastatin therapy on renal outcome in type 2 diabetes patients.
Methods: This was a single-center, prospective study, including 60 men with type 2 diabetes mellitus, aged between 40 and 65 years, statin-free, in whom the indication of a high dose statin treatment was indicated. Renal clearance was higher than 60 ml/mn/1.73 m2 in all patients. The patients had two visits, before and six months after the daily intake of 40 mg of atorvastatin. During each visit, they underwent a clinical examination and a fasting blood sample was collected for biological measurements including creatinine.
Results: The median age was 58 years (IQR:52-62). The median duration of diabetes was 81 months (IQR: 26-132). Thirty-one patients (52%) had hypertension. The median weight was 86.5 kg (IQR: 78-94). Twenty-seven patients (45%) had a diabetic nephropathy; a microalbuminuria in 23 cases (38%) and a macroproteinuria in 4 cases (7%). Glomerular filtration rate (GFR) was between 60 and 89 ml/mn/1.73 m2 in 16 patients (27%) before and 12 (20%) after statin use while GFR ≥ 90 ml/mn/1.73 m2 was observed in 44 (73%) before and in 48 (80%) after atorvastatin treatment. Serum creatinine levels decreased significantly from 74.5 µmol/l (IQR: 69.8-82.5) to 70.8 µmol/l (IQR: 64.9-78.3) (P=0.001). Creatinine clearance increased significantly from 100 ml/mn/1.73 m2 (IQR: 88-110) to 105 ml/mn/1.73 m2 (IQR: 93- 120) after atorvastatin therapy (P=0.001).
Conclusion: Long-term high-dose atorvastatin use improved renal function in type 2 diabetes patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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